Citation Impact
Citing Papers
New approaches and procedures for cancer treatment: Current perspectives
2021 Standout
Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy
2012
Independent and functional validation of a multi-tumour-type proliferation signature
2012
In situ click chemistry generation of cyclooxygenase-2 inhibitors
2017 Standout
Sulfonamides containing coumarin moieties selectively and potently inhibit carbonic anhydrases II and IX: Design, synthesis, inhibitory activity and 3D-QSAR analysis
2013
A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases
2011 StandoutNobel
Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target
2009
Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts
2013
Polypharmacology: drug discovery for the future
2012
Carbonic Anhydrases An Overview
2008
Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency
2010
Selective cytotoxicity and apoptosis induction in glioma cell lines by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon species
2012
Small Targeted Cytotoxics: Current State and Promises from DNA‐Encoded Chemical Libraries
2013
Synthesis of novel acridine and bis acridine sulfonamides with effective inhibitory activity against the cytosolic carbonic anhydrase isoforms II and VII
2013
Opportunities for Small Molecules in Cancer Immunotherapy
2020
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
2012 StandoutNobel
No effects of atorvastatin (10mg/d or 80mg/d) on nitric oxide, prostacyclin, thromboxane and oxidative stress in type 2 diabetes mellitus patients of the DALI study
2015
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Encoded libraries of chemically modified peptides
2015 StandoutNobel
Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines
2016
Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors
2017
Links between metabolism and cancer
2012
Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use
2014
Carbohydrate CuAAC click chemistry for therapy and diagnosis
2016
Carbonic anhydrase inhibition with natural products: novel chemotypes and inhibition mechanisms
2010
Benzenesulfonamides incorporating bulky aromatic/heterocyclic tails with potent carbonic anhydrase inhibitory activity
2015
Carbonic anhydrase inhibitors
2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I–XIV with a series of natural product polyphenols and phenolic acids
2010
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries
2009 StandoutNobel
Type 2 diabetes
2017 Standout
Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures
2014
Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review
2018 Standout
Interfering with pH regulation in tumours as a therapeutic strategy
2011
Tumor Microenvironmental Changes Induced by the Sulfamate Carbonic Anhydrase IX Inhibitor S4 in a Laryngeal Tumor Model
2014
Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including Acetazolamide in human Glioblastoma
2013
Artificial intelligence in drug development: present status and future prospects
2018 Standout
Carbonic Anhydrase Inhibitors Drug Design
2013
Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII
2015
Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II–trithiocarbonate adduct—An inhibitor mimicking the sulfonamide and urea binding to the enzyme
2009
Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges
2016 Standout
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I–XV
2010
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties
2017
The synthesis of novel pyrazole-3,4-dicarboxamides bearing 5-amino-1,3,4-thiadiazole-2-sulfonamide moiety with effective inhibitory activity against the isoforms of human cytosolic carbonic anhydrase I and II
2016
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
2012 StandoutNobel
Synthesis, characterization, in vitro cytotoxicity and antimicrobial investigation and evaluation of physicochemical properties of novel 4-(2-methylacetamide)benzenesulfonamide derivatives
2016
The Warburg Effect: How Does it Benefit Cancer Cells?
2016 Standout
Thiadiazole—a Promising Structure in Medicinal Chemistry
2012
Bidentate Zinc Chelators for α‐Carbonic Anhydrases that Produce a Trigonal Bipyramidal Coordination Geometry
2010
Carbonic Anhydrase IX: Regulation and Role in Cancer
2013
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library
2009
Metformin—mode of action and clinical implications for diabetes and cancer
2014
Hypoxia-inducible factor 1 and breast cancer metastasis
2015 StandoutNobel
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach
2014 Standout
ROS signalling in the biology of cancer
2017 Standout
Physiological functions of mineral micronutrients (Cu, Zn, Mn, Fe, Ni, Mo, B, Cl)
2009 Standout
Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
2018 StandoutNobel
Nano-magnetite (Fe3O4) as a support for recyclable catalysts in the development of sustainable methodologies
2013 Standout
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Recent Fascinating Aspects of the CuAAC Click Reaction
2020 StandoutNobel
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery
2013 Standout
Artificial intelligence in drug discovery and development
2020 Standout
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
The history and rationale of using carbonic anhydrase inhibitors in the treatment of peptic ulcers. In memoriam Ioan Puşcaş (1932–2015)
2015
Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
2012
Fundamentals of cancer metabolism
2016 Standout
Cucurbituril-Based Molecular Recognition
2015 Standout
Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches
2010
Deep Eutectic Solvents (DESs) and Their Applications
2014 Standout
Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue
2011 StandoutNobel
Schwefel(VI)‐fluorid‐Austausch (SuFEx): Eine weitere gute Anwendung für die Click‐Chemie
2014 StandoutNobel
Recent advances in 4-hydroxycoumarin chemistry. Part 1: Synthesis and reactions
2015
NH-1,2,3-Triazole Inhibitors of the VIM-2 Metallo-β-Lactamase
2010 StandoutNobel
New cyrhetrenyl and ferrocenyl sulfonamides: Synthesis, characterization, X-ray crystallography, theoretical study and anti- Mycobacterium tuberculosis activity
2017
Carbonic Anhydrase Inhibitors. Comparison of Aliphatic Sulfamate/Bis-sulfamate Adducts with Isozymes II and IX as a Platform for Designing Tight-Binding, More Isoform-Selective Inhibitors
2009
Combination therapy in combating cancer
2017 Standout
Natural Product-Based Phenols as Novel Probes for Mycobacterial and Fungal Carbonic Anhydrases
2011
An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities
2020
The Coumarin-Binding Site in Carbonic Anhydrase Accommodates Structurally Diverse Inhibitors: The Antiepileptic Lacosamide As an Example and Lead Molecule for Novel Classes of Carbonic Anhydrase Inhibitors
2009
Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule
2010
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2014 Standout
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
2012 StandoutNobel
Cu-Catalyzed Click Reaction in Carbohydrate Chemistry
2016
Synthesis and inhibition potency of novel ureido benzenesulfonamides incorporating GABA as tumor-associated carbonic anhydrase IX and XII inhibitors
2015
Synthesis, characterization, and biomedical assessment of novel bisimidazole–coumarin conjugates
2021 Standout
Selective Anti-Markovnikov Cyclization and Hydrofluorination Reaction in Superacid HF/SbF5: A Tool in the Design of Nitrogen-Containing (Fluorinated) Polycyclic Systems
2013
Fast 62–92 % yield preparation of amino acid dithiocarbamates in green solvent at room temperature
2013
Sulfamic Acid and Its N- and O-Substituted Derivatives
2013
The Essential Medicinal Chemistry of Curcumin
2017 Standout
Asymmetric Annulation of 3-Alkynylacrylaldehydes with Styrene-Type Olefins by Synergetic Relay Catalysis from AgOAc and Chiral Phosphoric Acid
2014
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis
2011
Facile Method for Preparing Surface-Mounted Cucurbit[8]uril-Based Rotaxanes
2014
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Mechanism of Copper(I)-Catalyzed 5-Iodo-1,2,3-triazole Formation from Azide and Terminal Alkyne
2015
Coumarins and Coumarin-Related Compounds in Pharmacotherapy of Cancer
2020 Standout
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?
2018 Standout
Carbonic Anhydrase Inhibitors: Inhibition of Human Erythrocyte Isozymes I and II with a Series of Phenolic Acids
2010
Discovery of 1,1′-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors
2015
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
Works of Alfonso Maresca being referenced
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors
2012
Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases
2012
5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors
2011
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies
2011
Synthesis of glycoconjugate carbonic anhydrase inhibitors by ruthenium-catalysed azide-alkyne 1,3-dipolar cycloaddition
2011
Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII
2011
Natural product coumarins that inhibit human carbonic anhydrases
2012
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors
2010
Carbonic Anhydrase Inhibitors: Inhibition of Cytosolic Carbonic Anhydrase Isozymes II and VII with Simple Aromatic Sulfonamides and Some Azo Dyes
2009
N-β-Glycosyl sulfamides are selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII
2011
Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model
2009
Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases
2012
Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active β-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c
2009
Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II
2011
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II
2012
Carbonic anhydrase inhibitors: Thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?
2008
(R)-/(S)-10-Camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases
2011
7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range
2010
Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: New selective tumor-associated carbonic anhydrase inhibitors
2012
Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII
2009
Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV
2012
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode α-carbonic anhydrases
2009
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II
2010
Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII
2012
Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations
2011
Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata
2011
Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo
2012
Tricyclic Sulfonamides Incorporating Benzothiopyrano[4,3-c]pyrazole and Pyridothiopyrano[4,3-c]pyrazole Effectively Inhibit α- and β-Carbonic Anhydrase: X-ray Crystallography and Solution Investigations on 15 Isoforms
2012
Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogenHelycobacter pyloriwith anions
2012
Discovery of Low Nanomolar and Subnanomolar Inhibitors of the Mycobacterial β-Carbonic Anhydrases Rv1284 and Rv3273
2009
Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors
2009
Dithiocarbamates strongly inhibit the β-class carbonic anhydrases fromMycobacterium tuberculosis
2011
Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins
2009
Anticonvulsant 4-Aminobenzenesulfonamide Derivatives with Branched-Alkylamide Moieties: X-ray Crystallography and Inhibition Studies of Human Carbonic Anhydrase Isoforms I, II, VII, and XIV
2011
Carbonic Anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry
2011
Affinity of Sulfamates and Sulfamides to Carbonic Anhydrase II Isoform: Experimental and Molecular Modeling Approaches
2010
Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II
2012
Targeting Hypoxic Tumor Cell Viability with Carbohydrate-Based Carbonic Anhydrase IX and XII Inhibitors
2011
Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors
2011
Inhibition of the β-class carbonic anhydrases fromMycobacterium tuberculosiswith carboxylic acids
2012
Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides
2010
Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three β-class carbonic anhydrases fromMycobacterium tuberculosis
2012
Three new aromatic sulfonamide inhibitors of carbonic anhydrases I, II, IV and XII
2012