Standout Papers
Citation Impact
Citing Papers
RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
2009 StandoutScience
Prospective identification of tumorigenic breast cancer cells
2003 Standout
2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease
2010 Standout
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
2003 StandoutNobel
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver
2002
Matters of life and death: programmed cell death at Cold Spring Harbor
1998
Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis
1997 Nobel
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
1998 Standout
Bid acts on the permeability transition pore complex to induce apoptosis
2000
Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines
2002
Propagation of the apoptotic signal by mitochondrial waves
2001
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator
2000
The Bcl-2 Protein Family
2000
tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak
2005
Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore
1999
Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death
1999
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis
2000
Role of caspases in the regulation of apoptotic pancreatic islet beta‐cells death
2004
The Hallmarks of Cancer
2000 Standout
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
1999 Nature
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
2005 StandoutNature
The biochemistry of apoptosis
2000 StandoutNature
BCL-2 family members and the mitochondria in apoptosis
1999 Standout
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Nitric oxide prevents tumor necrosis factor α-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8
2000
Relevance of Mutations in the TLR4 Receptor in Patients With Gram-Negative Septic Shock
2002
Role of Bcl‐2 family proteins in apoptosis: apoptosomes or mitochondria?
1998
Hepatic polyploidy and liver growth control
2000
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
2011 StandoutNature
The development of allergic inflammation
2008 StandoutNature
Anti-Inflammatory Cytokines
2000
Control of apoptosis by IP3and ryanodine receptor driven calcium signals
2000
Regulation of Bcl-xl Channel Activity by Calcium
1998
Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks
2003
Two CD95 (APO-1/Fas) signaling pathways
1998 Standout
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Cellular and Molecular Mechanisms of Liver Injury
2008
Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms
1999
Molecular characterization of mitochondrial apoptosis-inducing factor
1999 StandoutNature
Apoptosis Induction by Caspase-8 Is Amplified through the Mitochondrial Release of Cytochrome c
1998
Repopulation of Mouse Liver With Human Hepatocytes And In Vivo Infection With Hepatitis B Virus
2001
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
2000 StandoutNature
The Hallmarks of Aging
2013 Standout
Death-inducing functions of ligands of the tumor necrosis factor family: a Sanhedrin verdict
1998
NF-κB functions as a tumour promoter in inflammation-associated cancer
2004 StandoutNature
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
2005 Nature
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Regulation of immune responses by L-arginine metabolism
2005
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
1999 StandoutNature
The Epidemiology of Sepsis in the United States from 1979 through 2000
2003 Standout
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?
1999
Investigating Mitochondrial Redox Potential with Redox-sensitive Green Fluorescent Protein Indicators
2004 StandoutNobel
Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response
2006
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
1999
Dimerization and Processing of Procaspase-9 by Redox Stress in Mitochondria
2004
Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with Bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability
1999
The immunopathogenesis of sepsis
2002 StandoutNature
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator
2000
The Pathophysiology of Mitochondrial Cell Death
2004 StandoutScience
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore
2000
Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation
1998
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
2016 Standout
2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease
2010 Standout
Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis
1999
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
2000 StandoutScience
Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis
1998 Science
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
2000
CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.
1996
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease
2005 StandoutNobel
Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation
1998
Inhibition of Caspases In Vivo Protects the Rat Liver Against Alcohol‐Induced Sensitization to Bacterial Lipopolysaccharide
2001
Death Receptors: Signaling and Modulation
1998 StandoutScience
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
Biochemical Pathways of Caspase Activation During Apoptosis
1999 Standout
Tissue Engineering--Current Challenges and Expanding Opportunities
2002 StandoutScience
Mitochondrial Diseases in Man and Mouse
1999 StandoutScience
The role of glutathione in the regulation of apoptosis
1999
The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins
1998
Effects of Genomic Polymorphisms on the Course of Sepsis
2001
Mitochondrial damage due to SOD1 deficiency in SH‐SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1
2006
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Mitochondrial Dysfunction and Type 2 Diabetes
2005 StandoutScience
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
2000 StandoutScience
Bcl-2 and Bax modulate adenine nucleotide translocase activity.
2003
Mitochondria and Apoptosis
1998 StandoutScience
Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process
1999
Decoding the Patterns of Self and Nonself by the Innate Immune System
2002 StandoutScience
A Novel Polymorphism in the Toll-Like Receptor 2 Gene and Its Potential Association with Staphylococcal Infection
2000
MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
1999
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
1999 StandoutScience
Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria
1998
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death
2000
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
2013
Bcl-2 decreases the free Ca 2+ concentration within the endoplasmic reticulum
2000
Caspases: Enemies Within
1998 StandoutScience
Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells
2001
Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions
1998
Works of Alexandre Mignon being referenced
Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes
1998
Careful cardiovascular screening and follow-up of women with Turner syndrome before and during pregnancy is necessary to prevent maternal mortality
2008
Growth hormone prevents human monocytic cells from Fas-mediated apoptosis by up-regulating Bcl-2 expression
1999
Hepatic response to sepsis: Interaction between coagulation and inflammatory processes
2001
Polyamines Inhibit Lipopolysaccharide-Induced Nitric Oxide Synthase Activity in Rat Liver Cytosol
1997
Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice
1996
LPS Challenge in D-galactosamine–Sensitized Mice Accounts for Caspase-dependent Fulminant Hepatitis, not for Septic Shock
1999
Association of TNF2, a TNF-α Promoter Polymorphism, With Septic Shock Susceptibility and Mortality
1999 Standout
Differential protective effects of Bcl-xLand Bcl-2 on apoptotic liver injury in transgenic mice
1999
Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux
1998