Standout Papers
- A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells (2016)
- Generation of knock-in primary human T cells using Cas9 ribonucleoproteins (2015)
- CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions (2018)
Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
MicroRNA control of protein expression noise
2015 Science
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Divergent Transcription from Active Promoters
2008 Science
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells
2009 Science
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells
2009
TCR Repertoire and Foxp3 Expression Define Functionally Distinct Subsets of CD4+ Regulatory T Cells
2009
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo
2018
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Transcription factor Foxp3 and its protein partners form a complex regulatory network
2012
CRISPR/Cas9 genome editing in human hematopoietic stem cells
2018
Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature
2007
Control of the Embryonic Stem Cell State
2011
CRISPR RNAs trigger innate immune responses in human cells
2018
Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells
2013
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
2009 StandoutNobel
Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein
2009
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA
2009
Treg and CTLA-4: Two intertwining pathways to immune tolerance
2013
Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution
2011
Continuous requirement for the TCR in regulatory T cell function
2014
Embryonic stem cell–specific microRNAs promote induced pluripotency
2009
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
2010
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration
2017
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
The Principles of Engineering Immune Cells to Treat Cancer
2017
A CRISPR toolbox to study virus–host interactions
2017
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
2008
Integrating single-cell transcriptomic data across different conditions, technologies, and species
2018 Standout
Mediator and cohesin connect gene expression and chromatin architecture
2010 Nature
CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity
2023
SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state
2009
Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells
2011
MicroRNA control of signal transduction
2010
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
2009
FOXP3 and scurfy: how it all began
2014 StandoutNobel
Metazoan MicroRNAs
2018 Standout
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function
2011
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity
2011
Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition
2014
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses
2010 Nobel
Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells
2011
Regulatory T cells: how do they suppress immune responses?
2009 StandoutNobel
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins
2022
Induction of T cell anergy: integration of environmental cues and infectious tolerance
2010
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
2010
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network
2011
Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy
2018 StandoutNobel
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses
2009 Nature
Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity
2024 StandoutNobel
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
2010 Nature
Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage
2012
Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells
2009
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Waves of Retrotransposon Expansion Remodel Genome Organization and CTCF Binding in Multiple Mammalian Lineages
2012
Epigenetic modifications in pluripotent and differentiated cells
2010
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Topological domains in mammalian genomes identified by analysis of chromatin interactions
2012 StandoutNature
lincRNAs act in the circuitry controlling pluripotency and differentiation
2011 StandoutNature
miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110
2014 Nature
A systems approach to infectious disease
2020
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
2011 Nature
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Genome Regulation by Long Noncoding RNAs
2012 Standout
Inactivation of the microRNA-183/96/182cluster results in syndromic retinal degeneration
2013
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Regulatory T Cells: Mechanisms of Differentiation and Function
2007 Standout
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
2009
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
2009 StandoutNobel
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting
2009
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency
2009
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier
2012 StandoutNobel
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Conditional stability of T cells
2010 StandoutNatureNobel
Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6
2017
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
Mir-290–295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects
2011
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport
2017
Histone H3K27ac separates active from poised enhancers and predicts developmental state
2010 Standout
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Works of Alexander Marson being referenced
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
2017
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors
2016
Multiplexed droplet single-cell RNA-sequencing using natural genetic variation
2017
CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions
2018 StandoutNobel
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells
2016 StandoutNobel
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection
2019
The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation
2015
A Quantitative Genetic Interaction Map of HIV Infection
2020
Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering
2021 Nobel
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
2007 Nature
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies
2020
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
2008