Standout Papers
Citation Impact
Citing Papers
TRPA1 acts as a cold sensor in vitro and in vivo
2009
Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
2009
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation
2008
Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice
2007
Intranuclear Neuronal Inclusions in Huntington's Disease and Dentatorubral and Pallidoluysian Atrophy: Correlation between the Density of Inclusions andIT15CAG Triplet Repeat Length
1998
Nociceptors: a phylogenetic view
2009
Lessons from peppers and peppermint: the molecular logic of thermosensation
2003 StandoutNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo
1997
Apoptosis in the nervous system
2000 StandoutNature
p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia
2002
The diversity in the vanilloid (TRPV) receptor family of ion channels
2002
Time course of early motor and neuropathological anomalies in a knock‐in mouse model of Huntington's disease with 140 CAG repeats
2003
Regulation of nociceptive neurons by nerve growth factor and glial cell line derived neurotrophic factor
2002
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Excitotoxic Neuronal Death and the Pathogenesis of Huntington's Disease
2008
Huntington's disease
2007 Standout
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Transient receptor potential ion channels as participants in thermosensation and thermoregulation
2006
More than cool: Promiscuous relationships of menthol and other sensory compounds
2006 StandoutNobel
ThermoTRP channels and beyond: mechanisms of temperature sensation
2003 StandoutNobel
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
2004 Standout
Gene expression in Huntington's disease skeletal muscle: a potential biomarker
2005
2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3
2004
Opposite thermosensor in fruitfly and mouse
2003 StandoutNatureNobel
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain
2006
Piezo2 is required for Merkel-cell mechanotransduction
2014 StandoutNatureNobel
[3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution
2003
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
1999 Nature
A cell-based screen for drugs to treat Huntington's disease
2004
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
2004 StandoutNature
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice
2005
Structure–functional intimacies of transient receptor potential channels
2009
Targeting TRP channels for pain relief
2013
Transient receptor potential channels: targeting pain at the source
2008 StandoutNobel
Thermoreceptors and thermosensitive afferents
2009
Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease
2000
Biochemistry and pharmacology of endovanilloids
2007
Nociceptors Lacking TRPV1 and TRPV2 Have Normal Heat Responses
2004
Receptor-targeting mechanisms of pain-causing toxins: How ow?
2012 StandoutNobel
TRPV channels as temperature sensors
2003
Mouse Models of Huntington’s Disease
2018
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
2006 StandoutNature
Neuronal TRP channels: thermometers, pathfinders and life-savers
2008
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Agonist Recognition Sites in the Cytosolic Tails of Vanilloid Receptor 1
2002
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Low‐threshold heat response antagonized by capsazepine in chick sensory neurons, which are capsaicin‐insensitive
2000
The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice
2006
Direct Phosphorylation of Capsaicin Receptor VR1 by Protein Kinase Cε and Identification of Two Target Serine Residues
2002
Regional and progressive changes in brain expression of complexin II in a mouse transgenic for the Huntington’s Disease mutation
2004
Apoptosis in Huntington's disease
2003
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
TRPV1
2014
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Induction of vanilloid receptor channel activity by protein kinase C
2000 Nature
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
Extracellular Cations Sensitize and Gate Capsaicin Receptor TRPV1 Modulating Pain Signaling
2005
Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4
2005
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide
2001
The putative role of vanilloid receptor‐like protein‐1 in mediating high threshold noxious heat‐sensitivity in rat cultured primary sensory neurons
2002
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
2001
Uncoupling Proton Activation of Vanilloid Receptor TRPV1
2007
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
cAMP-Dependent Protein Kinase Regulates Desensitization of the Capsaicin Receptor (VR1) by Direct Phosphorylation
2002
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
Models and Mechanisms of Hyperalgesia and Allodynia
2009
Phosphoinositide regulation of TRPV1 revisited
2015
Ectopically Expressed CAG Repeats Cause Intranuclear Inclusions and a Progressive Late Onset Neurological Phenotype in the Mouse
1997
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
2001
Mechanosensation and pain
2004
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
A high‐threshold heat‐activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium
2007
Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions
1998
Intracellular Signaling in Primary Sensory Neurons and Persistent Pain
2008
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis
2005 StandoutNobel
Endovanilloids
2004
Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2
2008
Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1
2008
Anandamide-Evoked Activation of Vanilloid Receptor 1 Contributes to the Development of Bladder Hyperreflexia and Nociceptive Transmission to Spinal Dorsal Horn Neurons in Cystitis
2004
Warm Temperature-sensitive Transient Receptor Potential Vanilloid 4 (TRPV4) Plays an Essential Role in Thermal Hyperalgesia
2004
Sensing with TRP channels
2005
TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat
2008
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
2010 StandoutNobel
Ataxin-1 Nuclear Localization and Aggregation
1998
Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro
2009
Single‐channel properties of native and cloned rat vanilloid receptors
2002
Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells
2011 StandoutNobel
Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain
2005 StandoutNobel
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
Nociceptors—Noxious Stimulus Detectors
2007
TRPV3 is a temperature-sensitive vanilloid receptor-like protein
2002 Nature
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
2002
HIP-I: A huntingtin interacting protein isolated by the yeast two-hybrid system
1997
Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery
2005
Huntington disease: new insights on the role of huntingtin cleavage
2000
Warm Temperatures Activate TRPV4 in Mouse 308 Keratinocytes
2003
The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice
2005
Selective Neuronal Degeneration in Huntington's Disease
2006
Fly models of Huntington's disease
2003
A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides
2008 StandoutNobel
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
New order from neurological disorders
1999 Nature
TRPV3 is a calcium-permeable temperature-sensitive cation channel
2002 Nature
Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation
1997
Impaired Pressure Sensation in Mice Lacking TRPV4
2003
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
2001
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders
2003 Nature
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
2004
Contribution of TRPM8 Channels to Cold Transduction in Primary Sensory Neurons and Peripheral Nerve Terminals
2006
The ligand that came from within
2001
Anandamide Excites Central Terminals of Dorsal Root Ganglion Neurons via Vanilloid Receptor-1 Activation
2001
A Role of TRPA1 in Mechanical Hyperalgesia is Revealed by Pharmacological Inhibition
2007 StandoutNobel
A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila
2003
Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
1999
Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease
2000
Molecular and Cellular Limits to Somatosensory Specificity
2008
The TRP Superfamily of Cation Channels
2005
Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation
1997 Standout
TRP Channels and Pain
2013 StandoutNobel
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
2005 StandoutScienceNobel
Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
2001
Hot Receptors in the Brain
2006
Nuclear and Neuropil Aggregates in Huntington’s Disease: Relationship to Neuropathology
1999
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
2001 StandoutNobel
TRP ION CHANNELS AND TEMPERATURE SENSATION
2006 StandoutNobel
Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length
1999
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Transcriptional dysregulation in Huntington’s disease
2000
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
2001
Polyglutamines, nuclear inclusions and neurodegeneration
1997
Glutamine repeats and inherited neurodegenerative diseases: molecular aspects
1996
Prostaglandin and Protein Kinase A-Dependent Modulation of Vanilloid Receptor Function by Metabotropic Glutamate Receptor 5: Potential Mechanism for Thermal Hyperalgesia
2002
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
2002 StandoutScienceNobel
TRP Channels
2007 Standout
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Ca2+ Regulation of TRP Ion Channels
2018
Works of Alex Harper being referenced
Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice
1996 Standout
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
2000 StandoutNature