Standout Papers
Citation Impact
Citing Papers
Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
2018 Science
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
2004 Standout
Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis
2011
The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes
2017
Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy
2018
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
2015
Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation
2016
Design of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate
2014
The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice
2017
Cell type-specific Nrf2 expression in multiple sclerosis lesions
2015
pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2
2007 StandoutNobel
Biochemical and cellular effects of c-Src kinase-selective pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors
2000
Computational Approach for Prediction of Domain Organization and Substrate Specificity of Modular Polyketide Synthases
2003
Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
2005
Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis
2012
Biosynthesis of polyketide synthase extender units
2008
Structure Determination and Total Synthesis of Bottromycin A2: A Potent Antibiotic against MRSA and VRE
2008 StandoutNobel
Rheumatoid arthritis
2016 Standout
Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice
2013
Nrf2-Keap1 signaling in oxidative and reductive stress
2018 Standout
Modular Assembly of Glycoproteins: Towards the Synthesis of GlyCAM‐1 by Using Expressed Protein Ligation
2004 StandoutNobel
Posaconazole or Fluconazole for Prophylaxis in Severe Graft-versus-Host Disease
2007 Standout
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
2012
Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin
2000
Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds
2002
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
2015
Type I polyketide biosynthesis in bacteria (Part A — erythromycin biosynthesis) (1994 to 2000)
2001
Quantification of fumaric acid in liver, spleen and urine by high-performance liquid chromatography coupled to photodiode-array detection
2011
Nrf2 regulates ROS production by mitochondria and NADPH oxidase
2014
NRF2 and cancer: the good, the bad and the importance of context
2012
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
2011 Standout
Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease
2011
O-Pair Search with MetaMorpheus for O-glycopeptide characterization
2020 StandoutNobel
Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases
2015
Coloradocin, an antibiotic from a new Actinoplanes. I. Taxonomy, fermentation and biological properties.
1987
Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
2014
Psoriasis
2021 Standout
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
2016 Standout
Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
2012 StandoutNobel
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
2013
Natural products — The future scaffolds for novel antibiotics?
2005
Building-block selectivity of polyketide synthases
2003
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Natural products to drugs: natural product-derived compounds in clinical trials
2008 Standout
Biomimetic modeling of oxidative drug metabolism
2007
Skipping in a Hybrid Polyketide Synthase
2002
Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway
2012
Asymmetric Organocatalytic Domino Reactions
2007 Standout
Metabolic fluxes in riboflavin-producing Bacillus subtilis
1997 StandoutNobel
Revealing the human mucinome
2022 StandoutNobel
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
2018 Standout
Mechanisms and functions of Nrf2 signaling in Drosophila
2015
Molecular breeding of carotenoid biosynthetic pathways
2000 StandoutNobel
A83016F, a new member of the aurodox family.
1992
Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy
2013
Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases
2018
Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis
2012
The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units
2000
Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A Novel Modulator of Bach1 Activity
2014
Therapeutic strategies for rheumatoid arthritis
2003
Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells
2005 StandoutNobel
Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors
1997
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
OPT-80, a macrocyclic antimicrobial agent for the treatment ofClostridium difficileinfections: a review
2008
Nrf2—a therapeutic target for the treatment of neurodegenerative diseases
2015
Mechanisms of Bone Metastasis
2004 Standout
Myeloid cells — targets of medication in multiple sclerosis
2016
Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein
2015
Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase
2003 Standout
Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
2015
DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner
2015
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding
2016
Insights into Polyether Biosynthesis from Analysis of the Nigericin Biosynthetic Gene Cluster in Streptomyces sp. DSM4137
2007
The Biosynthetic Logic of Polyketide Diversity
2009 Standout
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
2016 Standout
Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis
2012
An Overview of the Advantages of KEAP1-NRF2 System Activation During Inflammatory Disease Treatment
2017
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Synthesis of a spiroacetal moiety of antitumor antibiotic ossamycin by anodic oxidation
2008
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method
2005 StandoutNobel
Transport, metabolism and elimination mechanisms of anti-HIV agents
1999
Tolerance and Specificity of Polyketide Synthases
1999
Multiple Sclerosis
2018 Standout
Translation and Protein Synthesis: Macrolides
2005
Safety, Tolerance, and Pharmacokinetic Studies of OPT-80 in Healthy Volunteers following Single and Multiple Oral Doses
2008
Electron-Based Dissociation Is Needed for O-Glycopeptides Derived from OpeRATOR Proteolysis
2020 StandoutNobel
Dimethyl fumarate for multiple sclerosis
2015
Emerging novel antifungal agents
2000
Vitamin D3 and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis
2015
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
2011
Type III Polyketide Synthase β-Ketoacyl-ACP Starter Unit and Ethylmalonyl-CoA Extender Unit Selectivity Discovered by Streptomyces coelicolor Genome Mining
2006
Status Report on the High-Throughput Characterization of Complex Intact O-Glycopeptide Mixtures
2018
Synthesis of the Decalin Subunit of Coloradocin
2000
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Avermectin Biosynthesis
1997 StandoutNobel
Total Synthesis and Stereochemical Assignment of (−)-Ushikulide A
2009
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Role of the K eap1/N rf2 pathway in neurodegenerative diseases
2015
A Comparative Analysis of Multiple Sclerosis–Relevant Anti-Inflammatory Properties of Ethyl Pyruvate and Dimethyl Fumarate
2015
Natural product and natural product derived drugs in clinical trials
2014 Standout
Regulated genes in psoriatic skin during treatment with fumaric acid esters
2014
Systemic Antifungal Agents
1998
Combinatorial biosynthesis: Lesson learned from nature
1998
Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2
2016
Permanent Culture of Macrophages at Physiological Oxygen Attenuates the Antioxidant and Immunomodulatory Properties of Dimethyl Fumarate
2014
Viral Proteases
2002
Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview
2015
Stereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase
1994 Science
Translation and Protein Synthesis: Macrolides
2005
Metal–Organic Frameworks in Biomedicine
2011 Standout
A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis
2018
Modular Organization of Genes Required for Complex Polyketide Biosynthesis
1991 Science
Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag
2011 StandoutNobel
The NRF 2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis
2018
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Synthesis of the oxa-bridged octalin system of two anti-anaerobe antibiotics, luminamicin and lustromycin
2007 StandoutNobel
Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE
2014
A C 35 Carotenoid Biosynthetic Pathway
2003 StandoutNobel
Metal–Organic Frameworks and Self-Assembled Supramolecular Coordination Complexes: Comparing and Contrasting the Design, Synthesis, and Functionality of Metal–Organic Materials
2012 Standout
Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1–Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases
2018
Isolation and Synthesis of Biologically Active Carbazole Alkaloids
2002 Standout
Toward the total synthesis of Luminamicin: construction of 14-membered lactone framework possessing versatile enol ether moiety
2012 StandoutNobel
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Mechanisms of white matter damage in multiple sclerosis
2014
Toward a Science of Metabolic Engineering
1991 Science
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity
2015 Standout
Structural requirements for the growth factor activity of the amino-terminal domain of urokinase.
1992
Works of Alex Buko being referenced
New antibiotics from genetically engineered actinomycetes. I. 2-norerythromycins, isolation and structural determinations.
1987
Inhibition of p56lckTyrosine Kinase by Isothiazolones
1999
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
2011 Standout
Phenelfamycins, a novel complex of elfamycin-type antibiotics. II. Isolation and structure determination.
1988
Implication of P450-Metabolite Complex Formation in the Nonlinear Pharmacokinetics and Metabolic Fate of (±)-(1′R*,3R*)-3-Phenyl-1-[(1′,2′,3′,4′-tetrahydro-5′,6′-methylene-dioxy-1′-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) in Dogs
2002
Dunaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. II. Isolation and elucidation of structures.
1991
Coloradocin, an antibiotic from a new Actinoplanes. II. Identity with luminamicin and elucidation of structure.
1987
Inhibition of 3C Protease from Human Rhinovirus Strain 1B by Peptidyl Bromomethylketonehydrazides
1999
Fusacandins A and B; Novel Antifungal Antibiotics of the Papulacandin Class from Fusarium sambucinum. II. Isolation and Structural Elucidation.
1995
Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.
1996
Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering
1998
Tiacumicins, a novel complex of 18-membered macrolides. II. Isolation and structure determination.
1987
Characterization of a posttranslational fucosylation in the growth factor domain of urinary plasminogen activator.
1991
Domain analysis of urokinase plasminogen activator (u-PA): Preparation and characterization of intact A-chain molecules
1992