Citation Impact
Citing Papers
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
2021
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Systematic mapping of functional enhancer–promoter connections with CRISPR interference
2016 Science
A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
2020
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions
2016
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy
2013 StandoutNobel
Autophagosomes form at ER–mitochondria contact sites
2013 StandoutNature
A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens
2019
Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome
2019
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation
2017
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
The genetics of ageing
2010 StandoutNature
Ribosome Footprint Profiling of Translation throughout the Genome
2016
Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice
2014
Genome-Editing Technologies: Principles and Applications
2016
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
2017
Hallmarks of aging: An expanding universe
2023 Standout
Low-Density Lipoprotein Receptor-Related Protein-1 Mediates Endocytic Clearance of Tissue Inhibitor of Metalloproteinases-1 and Promotes Its Cytokine-Like Activities
2014 StandoutNobel
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Nuclear lamins and laminopathies
2011
Metabolic Control of Longevity
2016
Effective gene expression prediction from sequence by integrating long-range interactions
2021 StandoutNobel
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Functional Classification and Experimental Dissection of Long Noncoding RNAs
2018 Standout
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
The Human Transcription Factors
2018 Standout
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Reprogramming aging and progeria
2012
Autophagy: Renovation of Cells and Tissues
2011 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response
2012
Dynamic RNA Modifications in Gene Expression Regulation
2017 Standout
RNA-binding proteins in neurodegeneration: Seq and you shall receive
2015
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation
2015
Metazoan MicroRNAs
2018 Standout
DNA Damage, Aging, and Cancer
2009 Standout
Progeria: A Paradigm for Translational Medicine
2014
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
High-performance medicine: the convergence of human and artificial intelligence
2018 Standout
Progeria syndromes and ageing: what is the connection?
2010
High-Throughput Approaches to Pinpoint Function within the Noncoding Genome
2017
Alternative polyadenylation of mRNA precursors
2016
CRISPR/Cas9-Based Engineering of the Epigenome
2017
Widespread Translational Remodeling during Human Neuronal Differentiation
2017 StandoutNobel
Plasma-Based Strategies for Therapeutic Modulation of Brain Aging
2019
Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
2013
U1 snRNP regulates cancer cell migration and invasion in vitro
2020 Standout
U1 snRNP telescripting regulates a size–function-stratified human genome
2017
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
2020 Standout
A snoRNA modulates mRNA 3′ end processing and regulates the expression of a subset of mRNAs
2017
The effects of p53 on whole organism longevity are mediated by autophagy
2008
Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR–Cas9 library
2016
A Generative Neural Network for Maximizing Fitness and Diversity of Synthetic DNA and Protein Sequences
2020
Chapter 12 Monitoring Autophagic Degradation of p62/SQSTM1
2009
Autophagy and Aging
2011 Standout
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Towards a comprehensive catalogue of validated and target-linked human enhancers
2020
The next generation of CRISPR–Cas technologies and applications
2019
Néstor–Guillermo progeria syndrome: A novel premature aging condition with early onset and chronic development caused by BANF1 mutations
2011
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
The role of senescent cells in ageing
2014 StandoutNature
Geroscience: Linking Aging to Chronic Disease
2014 Standout
Nuclear envelope alterations generate an aging‐like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
2010
The Hallmarks of Aging
2013 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome
2017
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Fast activation maximization for molecular sequence design
2021
GuideScan software for improved single and paired CRISPR guide RNA design
2017
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
Metzincin Proteases and Their Inhibitors: Foes or Friends in Nervous System Physiology?
2010
Autophagy and aging: keeping that old broom working
2008
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
The Posttranslational Processing of Prelamin A and Disease
2009
Molecular Pathology of Laminopathies
2021
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging
2010
Progress and trends in the development of therapies for Hutchinson–Gilford progeria syndrome
2020
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria
2021
Spermidine in health and disease
2018 StandoutScience
Four faces of cellular senescence
2011 Standout
The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression
2013
Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging
2011
MicroRNAs and their roles in aging
2012
De novo design of small beta barrel proteins
2023 StandoutNobel
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA
2022 StandoutNobel
Mouse Models to Disentangle the Hallmarks of Human Aging
2018
Machine Learning in Genomic Medicine: A Review of Computational Problems and Data Sets
2015
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
A Deep Neural Network for Predicting and Engineering Alternative Polyadenylation
2019
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens
2018 Standout
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of Alejandro P. Ugalde being referenced
Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
2010
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
2008
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
2008
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
2016
Micromanaging aging with miRNAs
2011
3’UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells
2016
Tumour-specific proline vulnerability uncovered by differential ribosome codon reading
2016 Nature
Alternative cleavage and polyadenylation: extent, regulation and function
2013
Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion
2013
Metalloproteases and the Degradome
2010
Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence
2018
Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53
2011
Premature aging in mice activates a systemic metabolic response involving autophagy induction
2008
Cell autonomous and systemic factors in progeria development
2011
Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3′-End Formation in the Failing Human Heart
2015
Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging?
2010