Citation Impact
Citing Papers
Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease
2010 StandoutScienceNobel
Exonal Elements and Factors Involved in the Depolarization-Induced Alternative Splicing of Neurexin 2
2012
The hnRNP family: insights into their role in health and disease
2016
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
2016 Standout
Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae.
1989
Frataxin is Reduced in Friedreich Ataxia Patients and is Associated with Mitochondrial Membranes
1997
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast
1995 StandoutNobel
Spliced leader RNA sequences can substitute for the essential 5′ end of U1 RNA during splicing in a mammalian in vitro system
1990
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
In vitrosplicing of mRNA precursors: 5' cleavage site can be predicted from the interaction between the 5' splice region and the 5' terminus of U1 snRNA
1988
A Common Core RNP Structure Shared between the Small Nucleoar Box C/D RNPs and the Spliceosomal U4 snRNP
2000 StandoutNobel
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
A conserved secondary structure for telomerase RNA
1991 StandoutNobel
Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking
2013 StandoutNobel
A Distinct Nuclear Import Pathway Used by Ribosomal Proteins
1997 StandoutNobel
Cloning and domain structure of the mammalian splicing factor U2AF
1992 Nature
A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome
1992
Regulation of circRNA biogenesis
2015 Standout
The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors
1992 StandoutNobel
Genetic depletion indicates a late role for U5 snRNP during in vitro spliceosome assembly
1991 StandoutNobel
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Quality control of mRNA 3′-end processing is linked to the nuclear exosome
2001 StandoutNatureNobel
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
2002 StandoutNatureNobel
The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
1987 StandoutNobel
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
Functional interaction of a novel 15.5kD [U4/U6middle dotU5] tri-snRNP protein with the 5' stem-loop of U4 snRNA
1999
Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing
1991
Exon mutations uncouple 5′ splice site selection from U1 snRNA pairing
1990 StandoutNobel
RNA travel: Tracks from DNA to cytoplasm
1993 StandoutNobel
The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC
1997 StandoutNobel
Analysis of RNase-A-resistant regions of adenovirus 2 major late precursor-mRNA in splicing extracts reveals an ordered interaction of nuclear components with the substrate RNA
1987
SR proteins can compensate for the loss of U1 snRNP functions in vitro.
1994
Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing
1989 StandoutNobel
Nopp 140 shuttles on tracks between nucleolus and cytoplasm
1992 StandoutNobel
Splicing and spliceosome formation of the yeastMATa1transcript require a minimum distance from the 5' splice site to the internal branch acceptor site
1988
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
2015 Standout
Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals
2014
A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly
1988
Splicing-related catalysis by protein-free snRNAs
2001 Nature
Cross-Intron Bridging Interactions in the Yeast Commitment Complex Are Conserved in Mammals
1997 StandoutNobel
Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure
2002
Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing.
1992
Targeted snRNP depletion reveals an additional role for mammalian U1 snRNP in spliceosome assembly
1990
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
1994 StandoutNobel
The Exosome: A Conserved Eukaryotic RNA Processing Complex Containing Multiple 3′→5′ Exoribonucleases
1997
Hierarchy for 5′ splice site preference determined in vivo
1990
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3′ processing and transcription termination
2007
Characterization of U4 and U6 interactions with the 5′ splice site using a S. cerevisiae in vitro trans-splicing system
2001
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Nuclear pre‐mRNA splicing in yeast
1989
Regulation by HIV Rev depends upon recognition of splice sites
1989 StandoutNobel
Who's on first? The U1 snRNP-5 splice site interaction and splicing
1991 StandoutNobel
Sequence-specific affinity selection of mammalian splicing complexes
1990
Identification and Characterization of a Nuclease Specific for the 3′ End of the U6 Small Nuclear RNA
1997
Purification of splicing factor SF1, a heat-stable protein that functions in the assembly of a presplicing complex.
1992
Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins
1996 StandoutScienceNobel
Multiple roles for U6 snRNA in the splicing pathway.
1990
The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding.
1990 StandoutNobel
Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors.
1991
U2 RNA from yeast is unexpectedly large and contains homology to vertebrate U4, U5, and U6 small nuclear RNAs
1986
Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.
1988
The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing
1987 Nature
Early Commitment of Yeast Pre-mRNA to the Spliceosome Pathway
1988 StandoutNobel
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing.
1988
Protein composition of mammalian spliceosomes assembled in vitro.
1990
A yeast splicing factor is localized in discrete subnuclear domains.
1992 StandoutNobel
Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes.
1987
The Yeast PRP6 Gene Encodes a U4/U6 Small Nuclear Ribonucleoprotein Particle (snRNP) Protein, and the PRP9 Gene Encodes a Protein Required for U2 snRNP Binding
1990 StandoutNobel
Accumulation of a Novel Spliceosomal Complex on Pre-mRNAs Containing Branch Site Mutations
1995
Presplicing complex formation requires two proteins and U2 snRNP.
1988
S. cerevisiae U1 RNA is large and has limited primary sequence homology to metazoan U1 snRNA
1987 StandoutNobel
Functional analysis of mutant Xenopus U2 snRNAs
1989
An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly
1988 Science
The Chemistry of Self-Splicing RNA and RNA Enzymes
1987 StandoutScienceNobel
Evidence from complementation assays in vitro that U5 snRNP is required for both steps of mRNA splicing.
1989
U1 small nuclear ribonucleoproteins are required early during spliceosome assembly.
1987
Microinjected U snRNAs are imported to oocyte nuclei via the nuclear pore complex by three distinguishable targeting pathways.
1992
Cloning and characterization of PSF, a novel pre-mRNA splicing factor.
1993
Trans -Splicing in Trypanosomes: Machinery and Its Impact on the Parasite Transcriptome
2011
Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.
1988
Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.
1989
Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles.
1988
RNA11 protein is associated with the yeast spliceosome and is localized in the periphery of the cell nucleus.
1988
Functional diversity of the hnRNPs: past, present and perspectives
2010
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains.
1990 StandoutNobel
RNA11 Protein is Associated with the Yeast Spliceosome and is Localized in the Periphery of the Cell Nucleus
1988
A novel role for the 3' region of introns in pre-mRNA splicing of Saccharomyces cerevisiae.
1987 StandoutNobel
U5 Small Nuclear Ribonucleoprotein: RNA Structure Analysis and ATP-Dependent Interaction with U4/U6
1989
Conservation of the Notch signalling pathway in mammalian neurogenesis
1997 StandoutNobel
Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter.
1992
Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes
1987
A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein
1986
In vitro reconstitution of functional yeast U2 snRNPs.
1989
Specific small nuclear RNAs are associated with yeast spliceosomes
1986 StandoutNobel
Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies
1992
UACUAAC is the preferred branch site for mammalian mRNA splicing.
1989
The yeast branchpoint sequence is not required for the formation of a stable U1 snRNA-pre-mRNA complex and is recognized in the absence of U2 snRNA.
1991 StandoutNobel
The PRP4 (RNA4) protein of Saccharomyces cerevisiae is associated with the 5' portion of the U4 small nuclear RNA.
1990
Interactions of Small Nuclear RNA's with Precursor Messenger RNA During in Vitro Splicing
1992 Science
Spliceosome assembly in yeast.
1987
The Mating of a Fly
1994 StandoutScienceNobel
Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
1989 StandoutNobel
A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA
1986
A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals.
1993
Nucleo-cytoplasmic transport of U snRNPs: definition of a nuclear location signal in the Sm core domain that binds a transport receptor independently of the m3G cap.
1993
A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.
1988 StandoutNobel
Associations between distinct pre-mRNA splicing components and the cell nucleus.
1991
An ATP-independent U2 small nuclear ribonucleoprotein particle/precursor mRNA complex requires both splice sites and the polypyrimidine tract.
1992
Early commitment of yeast pre-mRNA to the spliceosome pathway.
1988 StandoutNobel
Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.
1991
U5 small nuclear ribonucleoprotein: RNA structure analysis and ATP-dependent interaction with U4/U6.
1989
Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein
1991 Science
Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes
1986 StandoutNatureNobel
An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.
1991
5′ cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5′ splice region, not by the conserved 5′ GU
1987
Works of Albrecht Bindereif being referenced
Exon Circularization Requires Canonical Splice Signals
2014
HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats
2002
Identification and Functional Analysis of Mammalian Splicing Factors
1990
Assembly and nuclear transport of the U4 and U4U6 snRNPs
1992
Diverse roles of hnRNP L in mammalian mRNA processing: A combined microarray and RNAi analysis
2007
snRNA-specific role of SMN in trypanosome snRNP biogenesis in vivo
2011
Unexpected diversity in U6 snRNA sequences from trypanosomatids
1995
A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing
1988
Novel functional role of CA repeats and hnRNP L in RNA stability
2003
Crosslinking-immunoprecipitation (iCLIP) analysis reveals global regulatory roles of hnRNP L
2014
Intronic CA‐repeat and CA‐rich elements: a new class of regulators of mammalian alternative splicing
2005
Conserved domains of human U4 snRNA required for snRNP and spliceosome assembly
1990
SMN-assisted assembly of snRNP-specific Sm cores in trypanosomes
2009
Sm core variation in spliceosomal small nuclear ribonucleoproteins from Trypanosoma brucei
2006
Reconstitution of Functional Mammalian U4 Small Nuclear Ribonucleoprotein: Sm Protein Binding Is Not Essential for Splicing In Vitro
1992
trans-spliceosomal U6 RNAs of Crithidia fasciculata and Leptomonas seymouri: deviation from the conserved ACAGAG sequence and potential base pairing with spliced leader RNA.
1994
Reconstitution of functional mammalian U4 small nuclear ribonucleoprotein: Sm protein binding is not essential for splicing in vitro.
1992
Auto- and Cross-Regulation of the hnRNP L Proteins by Alternative Splicing
2009
Splicing function of mammalian U6 small nuclear RNA: conserved positions in central domain and helix I are essential during the first and second step of pre-mRNA splicing.
1994
Reconstituted mammalian U4/U6 snRNP complements splicing: a mutational analysis.
1992
Spliced leader RNA of trypanosomes: in vivo mutational analysis reveals extensive and distinct requirements for trans splicing and cap4 formation.
1996
Discrete domains of human U6 snRNA required for the assembly of U4/U6 snRNP and splicing complexes.
1990
A New U6 Small Nuclear Ribonucleoprotein-Specific Protein Conserved between cis- and trans-Splicing Systems
1991
In vitro reconstitution of snRNPs: a reconstituted U4/U6 snRNP participates in splicing complex formation.
1989
Ribonucleoprotein complex formation during pre-mRNA splicing in vitro.
1986
Ribonucleoprotein Complex Formation During Pre-mRNA Splicing in Vitro
1986
A new U6 small nuclear ribonucleoprotein-specific protein conserved between cis- and trans-splicing systems.
1991
An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly.
1987
Essential Role of a Trypanosome U4-Specific Sm Core Protein in Small Nuclear Ribonucleoprotein Assembly and Splicing
2010