Standout Papers
- Biosynthesis of the prion proteins in scrapie-infected cells in culture. (1994)
- Evidence for synthesis of scrapie prion proteins in the endocytic pathway. (1992)
- Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins (1988)
- Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains (1996)
- Regional mapping of prion proteins in brain. (1992)
- Synthesis and trafficking of prion proteins in cultured cells. (1992)
- Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters. (1992)
- Immunologic and Molecular Biologic Studies of Prion Proteins in Bovine Spongiform Encephalopathy (1993)
- Intracellular accumulation of the cellular prion protein after mutagenesis of its Asnlinked glycosylation sites (1990)
- Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. (1990)
- Rapid detection of Creutzfeldt‐Jakob disease and scrapie prion proteins (1990)
Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
The Neuropathology and Epidemiology of Bovine Spongiform Encephalopathy
1995
Heparin‐like molecules bind differentially to prion‐proteins and change their intracellular metabolic fate
1993
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein
1996 StandoutNobel
The Crystal Structure of the Globular Domain of Sheep Prion Protein
2004
Unaltered susceptibility to BSE in transgenic mice expressing human prion protein
1995 Nature
Mammalian Prion Biology
2004
Purification and properties of the cellular prion protein from Syrian hamster brain
1992 StandoutNobel
Pathway Complexity of Prion Protein Assembly into Amyloid
2002 Nobel
Lipid Rafts
2003
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Identification of Intermediate Steps in the Conversion of a Mutant Prion Protein to a Scrapie-like Form in Cultured Cells
1997
Chapter 37: PrPSc causes nerve cell death and stimulates astrocyte proliferation: a paradox
1992
Chemistry and biology of prions
1992
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing
1993
The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system
1995
Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state
1995
Regional distribution of protease‐resistant prion protein in fatal familial insomnia
1995
Cell-free formation of protease-resistant prion protein
1994 Nature
Lack of prion protein expression results in a neuronal phenotype sensitive to stress
2001
Characterisation of antisera raised against species-specific peptide sequences from scrapie-associated fibril protein and their application for post-mortem immunodiagnosis of spongiform encephalopathies
1994
Reversibility of Scrapie Inactivation Is Enhanced by Copper
1998
Mutation of the Prion Protein in Libyan Jews with Creutzfeldt–Jakob Disease
1991 StandoutNobel
Decreased receptor-mediated calcium response in prion-infected cells correlates with decreased membrane fluidity and IP sub 3 release
1996
Expression of Polyubiquitin and Heat‐Shock Protein 70 Genes Increases in the Later Stages of Disease Progression in Scrapie‐Infected Mouse Brain
1994
pH-dependent Stability and Conformation of the Recombinant Human Prion Protein PrP(90–231)
1997
Glycosylinositol Phospholipid Anchors of the Scrapie and Cellular Prion Proteins Contain Sialic Acid
1992 StandoutNobel
The chemistry of scrapie infection: implications of the ‘ice 9’ metaphor
1995
Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi
2003
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
1990 StandoutNobel
A 60-kDa Prion Protein (PrP) with Properties of Both the Normal and Scrapie-associated Forms of PrP
1995
Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
1996 Nature
Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C
1990
BIOLOGY AND GENETICS OF PRION DISEASES
1994
Scrapie prions: a three-dimensional model of an infectious fragment
1996
Potent Inhibition of Scrapie‐Associated PrP Accumulation by Congo Red
1992
Metal ions and prion diseases
2002
A 'unified theory' of prion propagation
1991 Nature
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins
1994 StandoutNobel
Fatal Familial Insomnia, a Prion Disease with a Mutation at Codon 178 of the Prion Protein Gene
1992
Conformational properties of the prion octa‐repeat and hydrophobic sequences
1997
Sensitive enzyme-linked immunosorbent assay for detection of PrPSc in crude tissue extracts from scrapie-affected mice
1997
Molecular basis of phenotypic variability in sporadc creudeldt‐jakob disease
1996
Thermal stability and conformational transitions of scrapie amyloid (prion) protein correlate with infectivity
1993 Nobel
Prion Protein Peptides Induce .alpha.-Helix to .beta.-Sheet Conformational Transitions
1995
Molecular properties of complexes formed between the prion protein and synthetic peptides
1997 StandoutNobel
Studies on peptide fragments of prion proteins
2001
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
1989 StandoutNatureNobel
Prion Protein Isoforms, a Convergence of Biological and Structural Investigations
1995 StandoutNobel
The Neurochemistry of Prion Diseases
1993
Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry
2000
Properties of the Scrapie Prion Protein: Quantitative Analysis of Protease Resistance
1994
Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein
1995
Mice with gene targetted prion protein alterations show that Prnp, Sine and Prni are congruent
1998
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Genetic and Infectious Prion Diseases
1993
Identification of cellular proteins binding to the scrapie prion protein
1990 StandoutNobel
Mutations and polymorphisms in the prion protein gene
1993
Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an α-helix
1997
Molecular biology of transmissible spongiform encephalopathies
1996
Scrapie strains retain their distinctive characteristics following passages of homogenates from different brain regions and spleen.
1997
Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse.
1993 StandoutNobel
GPI-anchored proteins are organized in submicron domains at the cell surface
1998 Nature
Molecular dynamics simulation of human prion protein including both N-linked oligosaccharides and the GPI anchor
2000
Amyloid fibrils in Gerstmann-Sträussler-Scheinker disease (Indiana and Swedish Kindreds) express only PrP peptides encoded by the mutant allele
1994
Prion Protein Genes: Evolutionary and Functional Aspects
1991
Scrapie agent reflication without the prion protein?
1993
Selective Neuronal Targeting in Prion Disease
1997 StandoutNobel
Human prion diseases
1994 StandoutNobel
Complete Genomic Sequence and Analysis of the Prion Protein Gene Region from Three Mammalian Species
1998 Nobel
The Octapeptide Repeats in Mammalian Prion Protein Constitute a pH-dependent Folding and Aggregation Site
2003
Consequences of manganese replacement of copper for prion protein function and proteinase resistance
2000
Lysosomes as key organelles in the pathogenesis of prion encephalopathies
1992
Fatal Familial Insomnia and Familial Creutzfeldt‐Jakob Disease: Clinical, Pathological and Molecular Features
1995
Direct observation of the nanoscale dynamics of membrane lipids in a living cell
2008 StandoutNatureNobel
Ionic Strength and Transition Metals Control PrPSc Protease Resistance and Conversion-inducing Activity
2004
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform 1 1Edited by M. Yaniv
1997 StandoutNobel
Eight prion strains have PrPSc molecules with different conformations
1998 Nobel
Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice
1991 StandoutNobel
Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes
1993
Insoluble wild–type and protease–resistant mutant prion protein in brains of patients with inherited prion disease
1996 StandoutNobel
Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene
1991
Prion Protein Biology
1998 Nobel
Molecular biology of prion diseases
1994
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
Chimeric prion protein expression in cultured cells and transgenic mice
1992 StandoutNobel
Deadly Conformations—Protein Misfolding in Prion Disease
1997
Prion (PrPSc)-specific epitope defined by a monoclonal antibody
1997 StandoutNatureNobel
Transmissible Mink Encephalopathy Species Barrier Effect Between Ferret and Mink: PrP Gene and Protein Analysis
1994
Molecular biology and pathogenesis of prion diseases
1996
Mice devoid of PrP are resistant to scrapie
1993 Standout
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein.
1996 StandoutNobel
Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice
1997 StandoutNobel
Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.
1994 StandoutNobel
Prion protein PrPc interacts with molecular chaperones of the Hsp60 family
1996
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
1993 StandoutNobel
Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.
1995
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells
1993
Chemical chaperones interfere with the formation of scrapie prion protein.
1996 StandoutNobel
Raman Spectroscopic Study on the Copper(II) Binding Mode of Prion Octapeptide and Its pH Dependence
1999
Unraveling prion diseases through molecular genetics
1989 StandoutNobel
Scrapie prions selectively modify the stress response in neuroblastoma cells.
1995
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation
1997 StandoutNobel
Physical Studies of Conformational Plasticity in a Recombinant Prion Protein
1997 StandoutNobel
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
1993 Standout
GENETICS OF PRIONS
1997 StandoutNobel
Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity
1996 StandoutNobel
The future of cloning
1999 StandoutNatureNobel
Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein
2002
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.
1996
Immunoaffinity purification and neutralization of scrapie prion infectivity.
1988
Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus.
1996 StandoutNobel
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.
1995 StandoutNobel
Detection of Prion Protein in Formalin-Fixed Brain by Hydrated Autoclaving Immunohistochemistry for the Diagnosis of Scrapie in Sheep
1994
Prions and prion proteins 1
1991 StandoutNobel
Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease
1997 StandoutNobel
Attempts to restore scrapie prion infectivity after exposure to protein denaturants.
1993
Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity
1996 StandoutScienceNobel
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.
1991 StandoutNobel
A Transmembrane Form of the Prion Protein in Neurodegenerative Disease
1998 ScienceNobel
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Propagation of prion strains through specific conformers of the prion protein
1997 StandoutNobel
Influence of pH on NMR Structure and Stability of the Human Prion Protein Globular Domain
2003
Assessment of Western Immunoblotting for the Confirmatory Diagnosis of Ovine Scrapie and Bovine Spongiform Encephalopathy (BSE)
1992
Prions
1998 StandoutNobel
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
1992 StandoutNobel
Regional Expression and Cellular Localization of the α1and β Subunit of High Voltage-Activated Calcium Channels in Rat Brain
1997
A scrapie-like unfolding intermediate of the prion protein domain PrP(121–231) induced by acidic pH
1998
Unusual Topogenic Sequence Directs Prion Protein Biogenesis
1990 StandoutScienceNobel
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform
1997 StandoutNobel
Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses.
1993
Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin.
1995
Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems
1992 StandoutNobel
Structure of the recombinant full-length hamster prion protein PrP(29–231): The N terminus is highly flexible
1997 StandoutNobel
Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice.
1996
Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy
1994
Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie.
1994 StandoutNobel
Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis
1991 StandoutNobel
Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein.
1994 StandoutNobel
Conservation of infectivity in purified fibrillary extracts of scrapie-infected hamster brain after sequential enzymatic digestion or polyacrylamide gel electrophoresis.
1990 Nobel
Prion Protein Selectively Binds Copper(II) Ions
1998 Nobel
N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state
1991
Prion protein and the transmissible spongiform encephalopathies
1997
Etiology and pathogenesis of prion diseases.
1995 StandoutNobel
French autochthonous scrapied sheep without the 136Val PrP polymorphism
1993
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.
1991
COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform
1997 StandoutNobel
Inherited prion diseases.
1994 StandoutNobel
Recombinant scrapie-like prion protein of 106 amino acids is soluble
1996 StandoutNobel
Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells.
1993 StandoutNobel
Prion liposomes
1990 StandoutNobel
Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein.
1994
Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity.
1993
Fatal familial insomnia and familial Creutzfeldt-Jakob disease: different prion proteins determined by a DNA polymorphism.
1994
Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans
1999 Nobel
Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein
1990 StandoutScienceNobel
Acidic pH and Detergents Enhance in Vitro Conversion of Human Brain PrPC to a PrPSc-like Form
2002
Determinants of carboxyl-terminal domain translocation during prion protein biogenesis
1994 StandoutNobel
Works of Albert Taraboulos being referenced
Reconstitution of Prion Infectivity from Solubilized Protease-resistant PrP and Nonprotein Components of Prion Rods
2001
Modulation of proteinase-K resistant prion protein by prion peptide immunization
2001
Subcellular trafficking abnormalities of a prion protein with a disrupted disulfide loop
1999
Scrapie‐Infected Mice and PrP Knockout Mice Share Abnormal Localization and Activity of Neuronal Nitric Oxide Synthase
1999
Immunologic and Molecular Biologic Studies of Prion Proteins in Bovine Spongiform Encephalopathy
1993 StandoutNobel
Cellular Heparan Sulfate Participates in the Metabolism of Prions
2003
Regional mapping of prion proteins in brain.
1992 StandoutNobel
Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform [published erratum appears in J Cell Biol 1995 Jul;130(2):501]
1995
Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells.
1991
Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation.
1990
Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.
1990
Synthesis and trafficking of prion proteins in cultured cells.
1992 StandoutNobel
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
1996 StandoutNobel
Evidence for synthesis of scrapie prion proteins in the endocytic pathway.
1992 StandoutNobel
Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform.
1993
Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins
1988 StandoutNobel
Scrapie prions alter receptor‐mediated calcium responses in cultured cells
1993
Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform
1997
Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.
1992 StandoutNobel
Rapid detection of Creutzfeldt‐Jakob disease and scrapie prion proteins
1990 StandoutNobel
Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells.
1990 StandoutNobel
Intracellular accumulation of the cellular prion protein after mutagenesis of its Asnlinked glycosylation sites
1990 StandoutNobel