Citation Impact
Citing Papers
Nature of the protein universe
2009 StandoutNobel
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
2012 StandoutNobel
The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling
2002
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Src-Mediated Phosphorylation of Focal Adhesion Kinase Couples Actin and Adhesion Dynamics to Survival Signaling
2004
Regulation of Focal Adhesion Kinase by a Novel Protein Inhibitor FIP200
2002
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration
2003
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
2006 StandoutNobel
Mapping the outer bulge with RRab stars from the VVV Survey
2016
Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration
1998
NMR Solution Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase in Complex with a Paxillin LD Peptide
2004
Inflammation and metabolic disorders
2006 StandoutNature
Circular RNAs are a large class of animal RNAs with regulatory potency
2013 StandoutNature
Focal Adhesion Kinase Is Upstream of Phosphatidylinositol 3-Kinase/Akt in Regulating Fibroblast Survival in Response to Contraction of Type I Collagen Matrices via a β1 Integrin Viability Signaling Pathway
2004
Signaling between Focal Adhesion Kinase and Trio
2003
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
Calcium control on InsP3-induced discharge of calcium from permeabilised hepatocyte pools
1993
Sleep after learning aids memory recall
2006
Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility
2003
Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets
2013
Identification of a New Pyk2 Isoform Implicated in Chemokine and Antigen Receptor Signaling
1998
Focal adhesion kinase: in command and control of cell motility
2005 Standout
Integrin signaling and cell growth control
1998
Insights into the role of IL-32 in cancer
2018
FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth
2002
Hepatocyte Growth Factor Induces ERK-dependent Paxillin Phosphorylation and Regulates Paxillin-Focal Adhesion Kinase Association
2002
MUSCLE: multiple sequence alignment with high accuracy and high throughput
2004 Standout
The Hallmarks of Cancer
2000 Standout
Opioids: first lessons from knockout mice
1999
Control of motile and invasive cell phenotypes by focal adhesion kinase
2004
Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways
1997
Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis
1997
Assembly of focal adhesions: progress, paradigms, and portents
1996
Sleep to Remember
2006
ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites
1993
Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again
2002
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells
1999
A Novel Link between Integrins, Transmembrane-4 Superfamily Proteins (CD63 and CD81), and Phosphatidylinositol 4-Kinase
1997
Negative regulation of FAK signaling by SOCS proteins
2003
Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK)
1998
Biochemical signals and biological responses elicited by the focal adhesion kinase
2001
Integrin signalling and tyrosine phosphorylation: just the FAKs?
1998
Phosphorylation of c-Crk II on the Negative Regulatory Tyr222 Mediates Nerve Growth Factor-induced Cell Spreading and Morphogenesis
2000
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Uniaxial Cyclic Stretch Induces Focal Adhesion Kinase (FAK) Tyrosine Phosphorylation Followed by Mitogen-Activated Protein Kinase (MAPK) Activation
2001
Integrin cytoplasmic interactions and bidirectional transmembrane signalling
1996
Focal Adhesion Kinase Regulation of N-WASP Subcellular Localization and Function
2004
Disruption of the kappa -opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa -agonist U-50,488H and attenuates morphine withdrawal
1998
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
1998 StandoutNatureNobel
Paxillin: a focal adhesion-associated adaptor protein
2001
Phosphorylation of Focal Adhesion Kinase at Tyrosine 861 Is Crucial for Ras Transformation of Fibroblasts
2004
The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression
1996
Inositol trisphosphate and calcium signalling
1993 StandoutNature
The focal adhesion kinase amino-terminal domain localises to nuclei and intercellular junctions in HEK 293 and MDCK cells independently of tyrosine 397 and the carboxy-terminal domain
2002
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
Paxillin and focal adhesion signalling
2000
Signaling through focal adhesion kinase
1997
Integrin-dependent Activation of the p70 Ribosomal S6 Kinase Signaling Pathway
1996
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
1997 StandoutNatureNobel
Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2
2003
Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins
2002
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival
1998
PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser‐910: Dissociation from Tyr‐397 phosphorylation and requirement for ERK activation
2004
Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity
2003 StandoutNobel
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
1995 StandoutNature
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.
1996
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Loading dependence of inositol 1,4,5-trisphosphate-induced Ca2+ release in the clonal cell line A7r5. Implications for the mechanism of quantal Ca2+ release.
1993
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.
1996
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Rapid filtration studies of the effect of cytosolic Ca2+ on inositol 1,4,5-trisphosphate-induced 45Ca2+ release from cerebellar microsomes
1994
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice
1999 StandoutScience
Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells.
2001
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
1996 Standout
Focal adhesion kinase is expressed in the angiogenic blood vessels of malignant astrocytic tumors in vivo and promotes capillary tube formation of brain microvascular endothelial cells.
2003
Focal adhesion kinase: the first ten years
2003
Co-activation of inositol trisphosphate-induced Ca2+ release by cytosolic Ca2+ is loading-dependent.
1994
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
1995 Standout
Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN
1998 Science
Near-infrared variability study of the central 2.3 × 2.3 arcmin2 of the Galactic Centre – II. Identification of RR Lyrae stars in the Milky Way nuclear star cluster
2017 StandoutNobel
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
1985 StandoutNobel
Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling
1999
Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases
1998
Cell Anchorage Permits Efficient Signal Transduction Between Ras and Its Downstream Kinases
1997
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
2005 StandoutScience
Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.
1996
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
THE OPTICAL GRAVITATIONAL LENSING EXPERIMENT: ANALYSIS OF THE BULGE RR LYRAE POPULATION FROM THE OGLE-III DATA
2012
Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motility
2004
The Beneficial Effect of Sleep in an Extended Jenkins and Dallenbach Paradigm
1977
Adenovirus Protein VII Functions throughout Early Phase and Interacts with Cellular Proteins SET and pp32
2005
DOCK180, a Major CRK-Binding Protein, Alters Cell Morphology upon Translocation to the Cell Membrane
1996
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology
1998
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.
1996
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis
2013 StandoutNobel
Smoothly graded Ca2+ release from inositol 1,4,5-trisphosphate-sensitive Ca2+ stores.
1994
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity
2000 StandoutNobel
Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration
1998
Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth
2012
Tumor Suppressor PTEN Inhibits Integrin- and Growth Factor–mediated Mitogen-activated Protein (MAP) Kinase Signaling Pathways
1998
Integrin Signaling
1999 StandoutScience
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Control of adhesion-dependent cell survival by focal adhesion kinase.
1996
About Sleep's Role in Memory
2013 Standout
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
The Effect of Sleep Before or After Learning on Memory
1984
Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2
1999
Drosophila myoblast city Encodes a Conserved Protein That Is Essential for Myoblast Fusion, Dorsal Closure, and Cytoskeletal Organization
1997
Focal adhesion kinase: at the crossroads of signal transduction
1997
Critical nodes in signalling pathways: insights into insulin action
2006 Standout
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
1997 StandoutScience
Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle
1999
Dissociation of FAK/p130CAS/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK
1999
Identification of a Novel Family of Targets of PYK2 Related to Drosophila Retinal Degeneration B (rdgB) Protein
1999
Luminal Ca2+ increases the affinity of inositol 1,4,5-trisphosphate for its receptor
1993
Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts
1997
Sleep and Memory: Retention 8 and 24 Hours After Initial Learning
1975
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
Chemistry of Inositol Lipid Mediated Cellular Signaling
1995
Targeting Pyk2 to β1-Integrin–Containing Focal Contacts Rescues Fibronectin-Stimulated Signaling and Haptotactic Motility Defects of Focal Adhesion Kinase–Null Cells
2001
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Protein structure prediction for the male-specific region of the human Y chromosome
2004 StandoutNobel
Isolation, characterization, and localization of the inositol 1,4,5-trisphosphate receptor protein in Xenopus laevis oocytes.
1992
Quantitative Changes in Integrin and Focal Adhesion Signaling Regulate Myoblast Cell Cycle Withdrawal
1999
Calcium Rises Locally Trigger Focal Adhesion Disassembly and Enhance Residency of Focal Adhesion Kinase at Focal Adhesions
2004
Geometric Control of Cell Life and Death
1997 StandoutScience
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Caspases: Enemies Within
1998 StandoutScience
Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins
1998
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor
2001 StandoutNobel
Structural Insight into the Mechanisms of Targeting and Signaling of Focal Adhesion Kinase
2002
Sleep, Dreams and memory: an overview
1995
Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold
2002
SMART, a simple modular architecture research tool: Identification of signaling domains
1998 Standout
Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2
1999
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
FAK integrates growth-factor and integrin signals to promote cell migration
2000
G Proteins and Olfactory Signal Transduction
2002
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
1999
Works of Alan Richardson being referenced
Signal transduction through integrins: A central role for focal adhesion kinase?
1995
Molecular cloning, expression and characterization of the human serine/threonine kinase Akt‐3
1999
The focal adhesion targeting sequence is the major inhibitory moiety of Fak-related non-kinase
2001
A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK
1996 Nature
Structure and function of inositol triphosphate receptors
1991
Variable Stars in Galactic Globular Clusters
2001
Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes.
1992
Effects of Ca2+ chelators on purified inositol 1,4,5-trisphosphate (InsP3) receptors and InsP3-stimulated Ca2+ mobilization
1993
The long range effect of sleep on retention
1963
Inhibition of Cell Spreading by Expression of the C-Terminal Domain of Focal Adhesion Kinase (FAK) Is Rescued by Coexpression of Src or Catalytically Inactive FAK: a Role for Paxillin Tyrosine Phosphorylation
1997
The identification of p130cas-binding proteins and their role in cellular transformation.
1996
Focal adhesion kinase: Structure and signalling
1994
Serine Phosphorylation of Focal Adhesion Kinase in Interphase and Mitosis: A Possible Role in Modulating Binding to p130Cas
2001
Prolonged exposure to inositol 1,4,5-trisphosphate does not cause intrinsic desensitization of the intracellular Ca(2+)-mobilizing receptor.
1992
Identification of integrin-stimulated sites of serine phosphorylation in FRNK, the separately expressed C-terminal domain of focal adhesion kinase: a potential role for protein kinase A
1997