Standout Papers
Citation Impact
Citing Papers
A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation
2006
Drosophila melanogaster Is a Genetically Tractable Model Host for Mycobacterium marinum
2003
Genome-Wide RNAi Screen for Host Factors Required for Intracellular Bacterial Infection
2005 Science
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
2003 StandoutScience
Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae
2002
Genetic Basis of Natural Variation in D. melanogaster Antibacterial Immunity
2004 Science
The Homeobox Gene Caudal Regulates Constitutive Local Expression of Antimicrobial Peptide Genes in Drosophila Epithelia
2003
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
The two origins of hemocytes in Drosophila
2003
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Transport of dsRNA into Cells by the Transmembrane Protein SID-1
2003 Science
Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
2005 StandoutNobel
Extensive Diversity of Ig-Superfamily Proteins in the Immune System of Insects
2005 Science
Genes that fight infection:what the Drosophila genome says about animal immunity
2000
A New Triggering Receptor Expressed on Myeloid Cells (Trem) Family Member, Trem-Like 4, Binds to Dead Cells and Is a DNAX Activation Protein 12-Linked Marker for Subsets of Mouse Macrophages and Dendritic Cells
2009 StandoutNobel
CD36 Is Required for Phagocytosis of Apoptotic Cells by Human Macrophages That Use Either a Phosphatidylserine Receptor or the Vitronectin Receptor (αvβ3)
1998
Insect Immunity: The Post-Genomic Era
2006
A Ubiquitin-Proteasome Pathway Represses the Drosophila Immune Deficiency Signaling Cascade
2002
Isolation and Characterization of Hemolymph Clotting Factors in Drosophila melanogaster by a Pullout Method
2004
Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila
2003
Rapid Secretion of Interleukin-1β by Microvesicle Shedding
2001
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster
2003
Host-pathogen interactions in drosophila: new tricks from an old friend
2006
Structure and metabolism of peptidoglycan and molecular requirements allowing its detection by the <I>Drosophila</I> innate immune system
2005
Toll receptors and pathogen resistance
2003
The Drosophila immune system detects bacteria through specific peptidoglycan recognition
2003
NMR Structure of Citrobacter freundii AmpD, Comparison with Bacteriophage T7 Lysozyme and Homology with PGRP Domains
2003
Regulation of cell death: the calcium–apoptosis link
2003 Standout
The roles of JAK/STAT signaling in Drosophila immune responses
2004
Phagocytosis and clearance of apoptotic cells is mediated by MER
2001 Nature
Corpse clearance defines the meaning of cell death
2000 Nature
Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria
2004 StandoutNobel
Peptidoglycan recognition proteins: on and off switches for innate immunity
2004
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
The Presumptive Phosphatidylserine Receptor Is Dispensable for Innate Anti-inflammatory Recognition and Clearance of Apoptotic Cells
2005
A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains
2007 StandoutNobel
Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal
2003
Apoptosis: controlled demolition at the cellular level
2007 Standout
Thicker Than Blood
2003
Antimicrobial Peptides as Mediators of Epithelial Host Defense
1999
An essential complementary role of NF‐κB pathway to microbicidal oxidants in Drosophila gut immunity
2006
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Sensing and signaling during infection in Drosophila
2004 StandoutNobel
A Scavenger Function for a DrosophilaPeptidoglycan Recognition Protein
2003
Stochastic yet biased expression of multiple Dscam splice variants by individual cells
2004
The Drosophila Immune Defense against Gram-Negative Infection Requires the Death Protein dFADD
2002 StandoutNobel
Functional Dissection of an Innate Immune Response by a Genome-Wide RNAi Screen
2004
Cell Death
2004 Standout
Toll-like receptors in innate immunity
2004 Standout
Human Peptidoglycan Recognition Protein-L Is an N-Acetylmuramoyl-L-alanine Amidase
2003
The Toll and Imd pathways are the major regulators of the immune response in Drosophila
2002
In Vivo RNA Interference Analysis Reveals an Unexpected Role for GNBP1 in the Defense against Gram-positive Bacterial Infection in Drosophila Adults
2004
Apoptotic mechanisms in the control of erythropoiesis
2004
JmjC-domain-containing proteins and histone demethylation
2006
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation
2002
Structural Basis for Preferential Recognition of Diaminopimelic Acid-type Peptidoglycan by a Subset of Peptidoglycan Recognition Proteins
2006
Innate recognition systems in insect immunity and development: new approaches in
2000
Secreted Bacterial Effectors and Host-Produced Eiger/TNF Drive Death in a Salmonella-Infected Fruit Fly
2004
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi
2006 StandoutNobel
Drosophila S2 cells: an alternative infection model for Listeria monocytogenes
2003
Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
2002 Nature
New insights into Drosophila larval haemocyte functions through genome-wide analysis
2005
PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan
2006
A Model of Bacterial Intestinal Infections in Drosophila melanogaster
2007 StandoutNobel
Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain
2004
A Drosophila Pattern Recognition Receptor Contains a Peptidoglycan Docking Groove and Unusual L,D-Carboxypeptidase Activity
2004 Nobel
Inducible Expression of Double-Stranded RNA Reveals a Role for dFADD in the Regulation of the Antibacterial Response in Drosophila Adults
2002
Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment
2003
Mediators of Chronic Obstructive Pulmonary Disease
2004
Drosophila immunity: paths and patterns
2003
The immune response of Drosophila
2003 StandoutNatureNobel
Selective upregulation and amplification of the lysyl oxidase like‐4 (LOXL4) gene in head and neck squamous cell carcinoma
2007
Functional analysis of immune response genes in Drosophila identifies JNK pathway as a regulator of antimicrobial peptide gene expression in S2 cells
2005
Characterization and Properties of a 1,3-β-d-Glucan Pattern Recognition Protein of Tenebrio molitor Larvae That Is Specifically Degraded by Serine Protease during Prophenoloxidase Activation
2003
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Bacterial recognition and signalling by the Drosophila IMD pathway
2005
Drosophila melanogaster S2 cells: a model system to study Chlamydia interaction with host cells
2005
Proteomic Analysis of the Drosophila Larval Hemolymph Clot
2004
Are innate immune signaling pathways in plants and animals conserved?
2005
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing
2006
Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression
1997 StandoutNobel
Identification of the haemoglobin scavenger receptor
2001 StandoutNature
Suppression of Drosophila cellular immunity by directed expression of the ExoS toxin GAP domain of Pseudomonas aeruginosa
2005
Signaling Role of Hemocytes in Drosophila JAK/STAT-Dependent Response to Septic Injury
2003
Identification of a factor that links apoptotic cells to phagocytes
2002 Nature
Blood cells of Drosophila: cell lineages and role in host defence
2003
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
1995
Immune Activation of NF-κB and JNK Requires Drosophila TAK1
2003
Targeting of TAK1 by the NF-κB protein Relish regulates the JNK-mediated immune response in Drosophila
2004
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
2007 StandoutNobel
A blast from the past: clearance of apoptotic cells regulates immune responses
2002
The Pathophysiology and Treatment of Sepsis
2003 Standout
Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships
2003
Peptidoglycan recognition protein (PGRP)‐LE and PGRP‐LC act synergistically in Drosophila immunity
2004
Downregulation of the Drosophila Immune Response by Peptidoglycan-Recognition Proteins SC1 and SC2
2006 StandoutNobel
The role of phosphatidylserine in recognition of apoptotic cells by phagocytes
1998
A mammalian peptidoglycan recognition protein with N-acetylmuramoyl-l-alanine amidase activity
2003
Antigen presentation to naive CD4 T cells in the lymph node
2003
Peptidoglycan Recognition Proteins Involved in 1,3-β-D-Glucan-dependent Prophenoloxidase Activation System of Insect
2004
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
The evolution and genetics of innate immunity
2001 StandoutNobel
Nimrod, a Putative Phagocytosis Receptor with EGF Repeats in Drosophila Plasmatocytes
2007
Sensing infection in Drosophila: Toll and beyond
2004 StandoutNobel
Cross-Priming of Cytotoxic T Cells Promoted by Apoptosis-Inducing Tumor Cell Reactive Antibodies?
2002
Identification of Tim4 as a phosphatidylserine receptor
2007 Nature
The road to Toll
2004
Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes
1997
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
A surprising simplicity to protein folding
2000 StandoutNatureNobel
Recognizing death: the phagocytosis of apoptotic cells
1998
Drosophila Genome-wide RNAi Screens: Are They Delivering the Promise?
2006
Inhibitor of apoptosis 2 and TAK1‐binding protein are components of the Drosophila Imd pathway
2005
Identification of Drosophila Gene Products Required for Phagocytosis of Candida albicans
2005
TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells
2007
Chronic obstructive pulmonary disease: molecular and cellularmechanisms
2003
The plant immune system
2006 StandoutNature
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Psidin Is Required in Drosophila Blood Cells for Both Phagocytic Degradation and Immune Activation of the Fat Body
2007
The immunopathogenesis of sepsis
2002 StandoutNature
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
The Role of Ubiquitination in Drosophila Innate Immunity
2005
Toll-like receptors and innate immunity
2001 Standout
Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathway
2005
Critical evaluation of the role of the Toll‐like receptor 18‐Wheeler in the host defense of Drosophila
2002
Apoptotic Cleavage of Cytoplasmic Dynein Intermediate Chain and P150GluedStops Dynein-Dependent Membrane Motility
2001
Toll-Like Receptors
2003 Standout
CD36 or αvβ3 and αvβ5 Integrins Are Not Essential for MHC Class I Cross-Presentation of Cell-Associated Antigen by CD8α+ Murine Dendritic Cells
2002
Drosophila immunity
1997
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
An Essential Role of the NF-κB/Toll-Like Receptor Pathway in Induction of Inflammatory and Tissue-Repair Gene Expression by Necrotic Cells
2001
A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph
2004
The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response
2009
Rel/NF-κB double mutants reveal that cellular immunity is central to Drosophila host defense
2006
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition
2005 Nobel
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
2000 StandoutNobel
Drosophila RNAi Screen Reveals CD36 Family Member Required for Mycobacterial Infection
2005 Science
A genome-wide analysis of immune responses in Drosophila
2001 StandoutNobel
Identification of the Integral Membrane Protein RM3/1 on Human Monocytes as a Glucocorticoid-Inducible Member of the Scavenger Receptor Cysteine-Rich Family (CD163)
1998
A Novel 40-kDa Protein Containing Six Repeats of an Epidermal Growth Factor-Like Domain Functions as a Pattern Recognition Protein for Lipopolysaccharide
2006
Structure classification-based assessment of CASP3 predictions for the fold recognition targets
1999
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells
2005
MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES
1999 Standout
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation
2002
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
The peptidoglycan recognition protein PGRP-SC1a is essential for Toll signaling and phagocytosis of Staphylococcus aureus in Drosophila
2006
Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)–deficient mice
2003
The Host Defense of Drosophila melanogaster
2007 StandoutNobel
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Peptidoglycan Molecular Requirements Allowing Detection by the Drosophila Immune Deficiency Pathway
2004
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
1997
Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro
2005
Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans
2001
Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor
2005
C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells
2001
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Innate Immune Recognition
2002 Standout
Regulation of CD163 on human macrophages: cross-linking of CD163 induces signaling and activation
1999
Antigen Presentation and T Cell Stimulation by Dendritic Cells
2002
Drosophila : The Genetics of Innate Immune Recognition and Response
2004
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells
2001
Caspase-mediated cleavage of syntaxin 5 and giantin accompanies inhibition of secretory traffic during apoptosis
2004
CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3).
1998
Aminophospholipid Asymmetry: A Matter of Life and Death
2003
Works of Alan Pearson being referenced
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
2002 Nature
A receptor for phosphatidylserine-specific clearance of apoptotic cells
2000 Nature
The SRCR superfamily: a family reminiscent of the Ig superfamily
1994
Scavenger receptors in innate immunity
1996
Drosophila Scavenger Receptor CI Is a Pattern Recognition Receptor for Bacteria
2001
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila
2003