Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability
2011
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
A New Pharmacologic Action of CCI-779 Involves FKBP12-Independent Inhibition of mTOR Kinase Activity and Profound Repression of Global Protein Synthesis
2008
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
2004 StandoutScience
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
2004 StandoutScience
Antimyeloma Activity of the Orally Bioavailable Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235
2009
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
mTORC2 Activity Is Elevated in Gliomas and Promotes Growth and Cell Motility via Overexpression of Rictor
2007
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Signalling and survival pathways in multiple myeloma
2006
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
Bone marrow-derived mesenchymal stem cells and the tumor microenvironment
2010
Opportunities and challenges in the development of kinase inhibitor therapy for cancer
2003
Mechanism of antimicrobial action of indolicidin
1998
Cutaneous Injury Induces the Release of Cathelicidin Anti-Microbial Peptides Active Against Group A Streptococcus
2001
Inflammation and cancer
2002 StandoutNature
Amphipathic, α-helical antimicrobial peptides
2000
Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity
2002
Antimicrobial peptides in animals and their role in host defences
2003
Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis
2012
Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat
2004
Hereditary Hemochromatosis — A New Look at an Old Disease
2004
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
2004 Standout
(Pre)analytical imprecision, between-subject variability, and daily variations in serum and urine hepcidin: Implications for clinical studies
2009
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
1999 Standout
Defensins: antimicrobial peptides of innate immunity
2003 Standout
Defensins in granules of phagocytic and non-phagocytic cells
1995
Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.
1989
Balancing Acts
2004 Standout
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
Multiple myeloma
2000 Standout
Characterization and transcriptional profiles of a Drosophila gene encoding an insect defensin
1994 StandoutNobel
Translational control in cancer
2010
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells
2002 StandoutNobel
SPAG11/isoform HE2C, an atypical anionic β-defensin-like peptide
2004
How bacteria resist killing by host-defense peptides
1994
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
2005
Systematic review of bisphosphonates for hypercalcaemia of malignancy
2004
Hepcidin and iron homeostasis
2012
Angiogenins: a new class of microbicidal proteins involved in innate immunity
2003
Upstream and downstream of mTOR
2004 Standout
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice
2004
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Integration of antimicrobial host defenses: role of the bactericidal/permeability-increasing protein
1994
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
2005 Standout
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors
2009
Conformation-dependent Antibacterial Activity of the Naturally Occurring Human Peptide LL-37
1998
Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice
2011
The Expression of the Gene Coding for the Antibacterial Peptide LL-37 Is Induced in Human Keratinocytes during Inflammatory Disorders
1997
Plant Defensins: Novel Antimicrobial Peptides as Components of the Host Defense System
1995
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
2009
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
Increased activated Akt expression in renal cell carcinomas and prognosis
2008
The immune response of Drosophila
2003 StandoutNatureNobel
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
A unifying model for mTORC1-mediated regulation of mRNA translation
2012 Nature
Haemochromatosis
2018
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
2003
STATs in cancer inflammation and immunity: a leading role for STAT3
2009 Standout
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form
2010
Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
2006
Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
1998
Anemia of inflammation: the hepcidin link
2005
Defensins
1990
Orientation and Dynamics of an Antimicrobial Peptide in the Lipid Bilayer by Solid-State NMR Spectroscopy
2001
Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins
1993
Structure–activity studies on magainins and other host defense peptides
1995
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
2006
The LKB1 tumor suppressor negatively regulates mTOR signaling
2004
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
2007
Efficacy of Pamidronate in Reducing Skeletal Complications in Patients with Breast Cancer and Lytic Bone Metastases
1996 Standout
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Isolation and identification of three bactericidal domains in the bovine α-lactalbumin molecule
1999
Primate defensins
2004
Hepcidin: from discovery to differential diagnosis
2007
Cancer-related inflammation
2008 StandoutNature
The detection, treatment, and biology of epithelial ovarian cancer
2010
The occurrence and significance of V gene mutations in B cell—Derived human malignancy
2001
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
2004
Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid
1996
Defensins
1995
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
2006
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
2002 Standout
Antimicrobial Peptides: An Emerging Concept in Cutaneous Biology
1998
Anemia of Chronic Disease
2005 Standout
Structural features and biological activities of the cathelicidin-derived antimicrobial peptides
2000
The Cathelicidin Family of Antimicrobial Peptide Precursors: A Component of the Oxygen‐Independent Defense Mechanisms of Neutrophilsa
1997
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
2009 Standout
Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus.
1993
Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
2003
Epithelial antibiotic induced in states of disease
1997
Iron Deficiency and Erythropoiesis: New Diagnostic Approaches
2003
Solid-State NMR Investigation of the Selective Perturbation of Lipid Bilayers by the Cyclic Antimicrobial Peptide RTD-1
2004
Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer
2004
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
2003 Standout
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
Inhibition of iron transport across human intestinal epithelial cells by hepcidin
2004
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)
1998 Science
The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy
2007
Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.
1996 StandoutNobel
Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients
1997 Science
By IL-1 Signaling, Monocyte-Derived Cells Dramatically Enhance the Epidermal Antimicrobial Response to Lipopolysaccharide
2003
Regulation of hepcidin transcription by interleukin-1 and interleukin-6
2005
Bacterial Biofilms: A Common Cause of Persistent Infections
1999 StandoutScience
Interleukin-6 induces hepcidin expression through STAT3
2006
Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
2004
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
2004 StandoutNobel
Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia
2010
The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance
2008
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
2004 Standout
Innate Defense against Influenza A Virus: Activity of Human Neutrophil Defensins and Interactions of Defensins with Surfactant Protein D
2006
Antibacterial activity of a synthetic peptide (PR-26) derived from PR-39, a proline-arginine-rich neutrophil antimicrobial peptide
1996
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
2003 Standout
Multiple Myeloma
2010
The intriguing role of polymorphonuclear neutrophils in antitumor reactions
2001
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod
2007
Hepcidin and iron regulation, 10 years later
2011
Immunoassay for human serum hepcidin
2008
Neutrophil Extracellular Traps Kill Bacteria
2004 StandoutScience
Release of aqueous contents from phospholipid vesicles induced by cecropin A (1–8)‐magainin 2 (1–12) hybrid and its analogues
1998
Systemic Iron Homeostasis
2013
Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms
1994
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
2006
Role of YadA in resistance to killing of Yersinia enterocolitica by antimicrobial polypeptides of human granulocytes
1996
Regulation of Hepcidin by Erythropoiesis: The Story So Far
2016
A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense.
1995 StandoutNobel
Membrane Pores Induced by Magainin
1996
Polysialic acid governs T-cell development by regulating progenitor access to the thymus
2009 StandoutNobel
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Hepcidin in iron overload disorders
2005
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes
1998 StandoutNobel
A C-terminal motif found in the β 2 -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na + /H + exchanger regulatory factor family of PDZ proteins
1998 StandoutNobel
Interleukin-1 and interleukin-1 antagonism
1991 Standout
Dysregulation of the TSC-mTOR pathway in human disease
2004 Standout
Effect of hepcidin on intestinal iron absorption in mice
2004
Regulation of Iron Metabolism by Hepcidin
2006
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
2005
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
2004
Functional differences between hepcidin 1 and 2 in transgenic mice
2003
Works of Alan Lichtenstein being referenced
BCL-X expression in multiple myeloma: possible indicator of chemoresistance.
1990
Interleukin-6 Inhibits Apoptosis of Malignant Plasma Cells
1995
Efficacy of Pamidronate in Reducing Skeletal Events in Patients with Advanced Multiple Myeloma
1996
Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group.
1998
Direct Cytotoxicity of Polymorphonuclear Leukocyte Granule Proteins to Human Lung-derived Cells and Endothelial Cells
1990
AKT Activity Determines Sensitivity to Mammalian Target of Rapamycin (mTOR) Inhibitors by Regulating Cyclin D1 and c-myc Expression
2004
Sulfur-containing amino acids decrease cisplatin cytotoxicity and uptake in renal tubule epithelial cell lines
2000
Mechanism of mammalian cell lysis mediated by peptide defensins. Evidence for an initial alteration of the plasma membrane.
1991
Cyclin D1 and c-myc Internal Ribosome Entry Site (IRES)-dependent Translation Is Regulated by AKT Activity and Enhanced by Rapamycin through a p38 MAPK- and ERK-dependent Pathway
2005
Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins
1988
Interleukin-6 activates phosphoinositol-3′ kinase in multiple myeloma tumor cells by signaling through RAS-dependent and, separately, through p85-dependent pathways
2004
Multiple Myeloma Clones are Derived from a Cell Late in B Lymphoid Development
1995
Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells
1993
Signal Pathways Involved in Activation of p70S6K and Phosphorylation of 4E-BP1 following Exposure of Multiple Myeloma Tumor Cells to Interleukin-6
2002
Role of the AKT kinase in expansion of multiple myeloma clones: effects on cytokine-dependent proliferative and survival responses
2002
Human neutrophil peptide defensins induce single strand DNA breaks in target cells
1991
Identification of malignant cells in multiple myeloma bone marrow with immunoglobulin VH gene probes by fluorescent in situ hybridization and flow cytometry.
1995
Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade
2005
Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779.
2002
Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity
1995
Involvement of Hepcidin in the Anemia of Multiple Myeloma
2008
In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2
2010
Interleukin-6–Induced Inhibition of Multiple Myeloma Cell Apoptosis: Support for the Hypothesis That Protection Is Mediated Via Inhibition of the JNK/SAPK Pathway
1998
Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance
2006
Lymphocyte cytotoxicity in the peritoneal cavity and blood of patients with ovarian cancer.
1984
Production of cytokines by bone marrow cells obtained from patients with multiple myeloma
1989
Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity.
1988
IL-6–Induced Stimulation of c-Myc Translation in Multiple Myeloma Cells Is Mediated by Myc Internal Ribosome Entry Site Function and the RNA-Binding Protein, hnRNP A1
2008
Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non–Small Cell Lung Cancer
2005
Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor
2010
Role of the AKT kinase in expansion of multiple myeloma clones: effects on cytokine-dependent proliferative and survival responses
2002
The AKT kinase is activated in multiple myeloma tumor cells
2001
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
2003 Standout