Standout Papers
Citation Impact
Citing Papers
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney
2005
Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å
1991 StandoutScience
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis
2004
Expression and Regulation of G Protein-Coupled Receptor Kinase 5 and β-Arrestin-1 in Rat Thyroid FRTL5 Cells
1996
G Protein-coupled Receptor Kinase GRK4
1997
Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs
2004
The Genetics of Wilms' Tumor
1992
A Dominant Negative Mutant of the G Protein-Coupled Receptor Kinase 2 Selectively Attenuates Adenosine A2 Receptor Desensitization
1997
The epidemiology of Huntington's disease
1992
Unstable DNA sequence in myotonic dystrophy
1992
A tumor chromosome rearrangement further defines the 11p13 Wilms tumor locus
1991
High-resolution localization of 69 potential human zinc finger protein genes: A number are clustered
1992
Embryonic induction
1993
The GRK4 Subfamily of G Protein-coupled Receptor Kinases
1999 StandoutNobel
Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the α1B-Adrenergic Receptor
1996
Heterogeneity in β-Adrenergic Receptor Kinase Expression in the Lung Accounts for Cell-specific Desensitization of the β2-Adrenergic Receptor
1997
Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development
1992
WT-1 is required for early kidney development
1993 Standout
p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
2018
CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
1994
Involvement of G Protein-coupled Receptor Kinase 5 in Homologous Desensitization of the Thyrotropin Receptor
1996
Highwire Regulates Synaptic Growth in Drosophila
2000
Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4
1996 Standout
Triplet repeat mutations in human disease
1992 Science
Stereochemical basis of DNA recognition by Zn fingers
1994
Lipid-mediated Regulation of G Protein-coupled Receptor Kinases 2 and 3
1995
DLG5 and OCTN
2004
Inflammatory bowel disease: cause and immunobiology
2007 Standout
Genomewide Search in Canadian Families with Inflammatory Bowel Disease Reveals Two Novel Susceptibility Loci
2000
Tumor suppressor genes
1991 Standout
Positional cloning of the mouse obese gene and its human homologue
1994 StandoutNature
Unstable expansion of CAG repeat in hereditary dentatorubral–pallidoluysian atrophy (DRPLA)
1994
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo
1993
Follicular B helper T cells in antibody responses and autoimmunity
2005
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1
1993
G Protein-coupled Receptor Kinase GRK2 Is a Phospholipid-dependent Enzyme That Can Be Conditionally Activated by G Protein βγ Subunits
1996
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
Cooperation between oncogenes
1991
The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
1991
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
2003
Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus
1991
Linkage of Inflammatory Bowel Disease to Human Chromosome 6p
1999
A tiger behind many doors: multiple genetic pathways to malignant glioma
1995
Characterization of the G Protein-coupled Receptor Kinase GRK4
1996 StandoutNobel
Anticipation in inflammatory bowel disease: A phenomenon caused by an accumulation of confounders
2000
Molecular themes in oncogenesis
1991 StandoutNobel
Abnormal splicing of the leptin receptor in diabetic mice
1996 StandoutNature
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor
1993 Standout
Reverse Mutation in Myotonic Dystrophy
1993
Twelve amplified and expressed genes localized in a single domain in glioma
1996
Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor gene
1990
A cosmid contig and high resolution restriction map of the 2 megabase region containing the Huntington's disease gene
1993
The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes
1992
An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes
1989
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
A Genome-Wide Search Identifies Potential New Susceptibility Loci for Crohnʼs Disease
1999
The Egr transcription factor family: From signal transduction to kidney differentiation
1992
A Genome Scan in 260 Inflammatory Bowel Disease-Affected Relative Pairs
2003
Using a Genome-Wide Scan and Meta-analysis to Identify a Novel IBD Locus and Confirm Previously Identified IBD Loci
2002
Genome-wide search in Finnish families with inflammatory bowel disease provides evidence for novel susceptibility loci
2003
XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease
2008 Standout
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
A candidate gene for the mouse mutation tubby
1996 Nature
Correlation between CTG trinucleotide repeat length and frequency of severe congenital myotonic dystrophy
1992
Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5
1994
Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11
1995 StandoutNatureNobel
A Genome Scan in 260 Inflammatory Bowel Disease-Affected Relative Pairs
2004
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
Genetic variation in DLG5 is associated with inflammatory bowel disease
2004
High-Density Genome Scan in Crohn Disease Shows Confirmed Linkage to Chromosome 14q11-12
2000
Location of agonist‐dependent‐phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype)
1994
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Regulation of G protein-coupled Receptor Kinase 5 (GRK5) by Actin
1998 StandoutNobel
Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome
1991
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Current status of genetics research in inflammatory bowel disease
2005
WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour
1991 Nature
Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation.
1990
THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
1998
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.
1993
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
2008 StandoutScienceNobel
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6.
1994
Identification of additional members of human G-protein-coupled receptor kinase multigene family.
1993
Modulation of DNA Binding Specificity by Alternative Splicing of the Wilms Tumor wt1 Gene Transcript
1992 Science
Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility
1995
Polypeptide variants of beta-arrestin and arrestin3
1993
Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites.
1992
Gene for Familial Psoriasis Susceptibility Mapped to the Distal End of Human Chromosome 17q
1994 Science
Role for the Wilms tumor gene in genital development?
1990
The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
1996 StandoutScience
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.
1994
A FOS protein is present in a complex that binds a negative regulator of MYC.
1989 StandoutNobel
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Myotonic Dystrophy Mutation: an Unstable CTG Repeat in the 3′ Untranslated region of the Gene
1992 Science
Binding of the Wilms' Tumor Locus Zinc Finger Protein to the EGR-1 Consensus Sequence
1990 Science
Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus)
1996 StandoutNobel
Differentially regulated expression of the G-protein-coupled receptor kinases, betaARK and GRK6, during myelomonocytic cell development in vitro
1996
Comparative sequence analysis of the human and pufferfish Huntington's disease genes
1995 StandoutNobel
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
1993 Standout
Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.
1993
Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.
1994
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
Regulatory elements that modulate expression of human c-myc.
1987 StandoutNobel
Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease
2000
Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus
1995 StandoutScience
A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.
1989
Structure of the human gene encoding the beta-adrenergic receptor kinase.
1994
Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°
1991 StandoutScienceNobel
Regulation of Presynaptic Terminal Organization by C. elegans RPM-1, a Putative Guanine Nucleotide Exchanger with a RING-H2 Finger Domain
2000
Genetic Dissection of Complex Traits
1994 StandoutScience
Evidence for WT1 as a Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT.
1991
Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients
1990 StandoutScience
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
1997 StandoutScience
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.
1992
Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1
1992 Science
Zinc finger point mutations within the WT1 gene in Wilms tumor patients.
1992
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
1994 StandoutNobel
A Mouse Model of the Aniridia-Wilms Tumor Deletion Syndrome
1990 Science
The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene.
1992
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Mechanisms in Protein O-Glycan Biosynthesis and Clinical and Molecular Aspects of Protein O-Glycan Biosynthesis Defects: A Review
2006
Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.
1994
Crystal Structure of a Five-Finger GLI-DNA Complex: New Perspectives on Zinc Fingers
1993 Science
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Rat G Protein-Coupled Receptor Kinase GRK4: Identification, Functional Expression, and Differential Tissue Distribution of Two Splice Variants*
1998
Linkage disequilibrium between the fragile X mutation and two closely linked CA repeats suggests that fragile X chromosomes are derived from a small number of founder chromosomes.
1993
Structure and mechanism of the G protein-coupled receptor kinases.
1993 StandoutNobel
Works of Alan Buckler being referenced
Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy
1992 Nature
A gene from chromosome 4p 16.3 with similarity to a superfamily of transporter proteins
1993
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor
1990
Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer
2014
The candidate Wilms' tumour gene is involved in genitourinary development
1990 Nature
A novel G protein-coupled receptor kinase gene cloned from 4p16.3
1992
Efficiency and specificity of gene isolation by exon amplification
1993
Isolation of genes from complex sources of mammalian genomic DNA using exon amplification
1994
MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p
1994
A Genomewide Analysis Provides Evidence for Novel Linkages in Inflammatory Bowel Disease in a Large European Cohort
1999
The diastrophic dysplasia gene encodes a novel sulfate transporter: Positional cloning by fine-structure linkage disequilibrium mapping
1994
Cloning of the α–adducin gene from the Huntington's disease candidate region of chromosome 4 by exon amplification
1992
Expression of the Wilms' tumor gene WT1 in the murine urogenital system.
1991
Transcriptional and posttranscriptional control of c-myc gene expression in WEHI 231 cells.
1986
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus
1990 Standout
Systematic screening of an arrayed cDNA library by PCR.
1995
Alternative splicing and genomic structure of the Wilms tumor gene WT1.
1991
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome
1998
Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line.
1995
Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development.
1991
Independent regulation of transcription of the two strands of the c-myc gene.
1987
Isolation, Characterization, and Expression of the Murine Wilms’ Tumor Gene (WT1) During Kidney Development
1991
Exon amplification: a strategy to isolate mammalian genes based on RNA splicing.
1991
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.
1990
Independent Regulation of Transcription of the Two Strands of the c-myc Gene
1987
p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins.
1996