Standout Papers
Citation Impact
Citing Papers
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Systemic delivery of factor IX messenger RNA for protein replacement therapy
2017
Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells
2003
Hierarchical targeted hepatocyte mitochondrial multifunctional chitosan nanoparticles for anticancer drug delivery
2015
Self-assembled mRNA vaccines
2021
Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature
2014
Transthyretin: a multifaceted protein
2014
All‐In‐One Dendrimer‐Based Lipid Nanoparticles Enable Precise HDR‐Mediated Gene Editing In Vivo
2021
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Progress and challenges towards targeted delivery of cancer therapeutics
2018 Standout
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
Therapeutic siRNA: state of the art
2020
Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events
2009
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
2021 StandoutNobel
Lipid nanoparticle technology for therapeutic gene regulation in the liver
2020
Imidazole groups on a linear, cyclodextrin-containing polycation produce enhanced gene delivery via multiple processes
2006
Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
2021 StandoutNobel
Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo
2020
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
2017 StandoutNobel
Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
2012
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
2017 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Screening Libraries to Discover Molecular Design Principles for the Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers Derived from Plant Phenolic Acids
2023 StandoutNobel
Gold Nanoparticles for Nucleic Acid Delivery
2014
Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin
2009
Going beyond the liver: Progress and challenges of targeted delivery of siRNA therapeutics
2015
Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
2019
A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amine)s
2005
The challenge and prospect of mRNA therapeutics landscape
2020
In Vivo Delivery of RNAi with Lipid-Based Nanoparticles
2011
Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery
2020
Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications
2012
In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier
2012
MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles
2012
Chitosan-based siRNA delivery systems
2013
Cancer nanomedicine: progress, challenges and opportunities
2016 Standout
Delivery technologies for in utero gene therapy
2020
Lipid nanoparticles for mRNA delivery
2021 Standout
Ionizable Amphiphilic Dendrimer‐Based Nanomaterials with Alkyl‐Chain‐Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo
2014
Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells
2022 StandoutNobel
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines
2023 StandoutNobel
Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery
2021 StandoutNobel
The landscape of mRNA nanomedicine
2022
Trimethylated chitosans as non-viral gene delivery vectors: Cytotoxicity and transfection efficiency
2005
PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake
2018 StandoutNobel
Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
2016
Dexamethasone prodrugs as potent suppressors of the immunostimulatory effects of lipid nanoparticle formulations of nucleic acids
2018
A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo
2012
Lipid-based vectors for siRNA delivery
2012
Cellular Uptake of Cationic Polymer-DNA Complexes Via Caveolae Plays a Pivotal Role in Gene Transfection in COS-7 Cells
2007
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency
2020
Using microfluidics for scalable manufacturing of nanomedicines from bench to GMP: A case study using protein-loaded liposomes
2020
Lipid nanoparticles for delivery of messenger RNA to the back of the eye
2019
Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals
2015
Delivery materials for siRNA therapeutics
2013 Standout
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administration
2010
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
2014
Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs
2021 StandoutNobel
In vitro and ex vivo strategies for intracellular delivery
2016 Nature
Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases
2019
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
2011
Payload distribution and capacity of mRNA lipid nanoparticles
2022
Brief update on endocytosis of nanomedicines
2019
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13
2012
The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation
2010
Lipid-based systemic delivery of siRNA
2009
The current state and future directions of RNAi-based therapeutics
2019
Delivery of mRNA Therapeutics for the Treatment of Hepatic Diseases
2018
Nanoparticle–aptamer bioconjugates for cancer targeting
2006
Therapeutic targeting of microRNAs: current status and future challenges
2014
Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes
2020
An ionizable lipid toolbox for RNA delivery
2021 StandoutNobel
Reduction/pH dual-sensitive PEGylated hyaluronan nanoparticles for targeted doxorubicin delivery
2013
Biomedical applications of biodegradable polymers
2011 Standout
Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery
2021 StandoutNobel
Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug
2010
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
2021 StandoutNobel
Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
2015 StandoutNobel
<div>Lipid nanoparticles for targeted siRNA delivery – going from bench to bedside</div>
2016
Improving Site‐Directed RNA Editing In Vitro and in Cell Culture by Chemical Modification of the GuideRNA
2014
Paving the Road for RNA Therapeutics
2020
PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: Faster PEG shedding attenuates anti-PEG IgM production
2020
Quantum dots as a platform for nanoparticle drug delivery vehicle design
2012
Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA
2009
Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems
2017
Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing
2021
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Non-viral vectors for gene-based therapy
2014 Standout
mRNA vaccine for cancer immunotherapy
2021
Paclitaxel-clusters coated with hyaluronan as selective tumor-targeted nanovectors
2010
Microfluidic formulation of nanoparticles for biomedical applications
2021
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
2020
Design of polymeric nanoparticles for biomedical delivery applications
2012
Lipid Nanoparticle Systems for Enabling Gene Therapies
2017
Highly effective and slow-biodegradable network-type cationic gene delivery polymer: Small library-like approach synthesis and characterization
2005
A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier
2006
Site‐Directed RNA Editing with Antagomir Deaminases — A Tool to Study Protein and RNA Function
2014
Combinatorially Designed Lipid‐like Nanoparticles for Intracellular Delivery of Cytotoxic Protein for Cancer Therapy
2014
Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination
2010
Drug delivery systems for RNA therapeutics
2022
Attacking the genome: emerging siRNA nanocarriers from concept to clinic
2012
Intracellular delivery of core–shell fluorescent silica nanoparticles
2007
Treating metastatic cancer with nanotechnology
2011
Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
2020
Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse
2017
Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA
2016
Poly(β-amino esters): Procedures for Synthesis and Gene Delivery
2008
The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA
2016
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
2019
In vivo delivery of miRNAs for cancer therapy: Challenges and strategies
2014
Thermo- and pH-responsive polymers in drug delivery☆
2006 Standout
Materials for non-viral intracellular delivery of messenger RNA therapeutics
2015
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
2017 Standout
Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug
2020
Dendritic α,ε-Poly(L-lysine)s as Delivery Agents for Antisense Oligonucleotides
2007
Lipid‐based nanotherapeutics for siRNA delivery
2009
Nanoparticles for nucleic acid delivery: Applications in cancer immunotherapy
2019
Advanced materials and processing for drug delivery: The past and the future
2012
Polycation-Based Gene Therapy: Current Knowledge and New Perspectives
2011
Lipid nanoparticles for nucleic acid delivery: Current perspectives
2020
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
2009
Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines
2017
Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo
2017
Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization
2016
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles
2012
A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
2018
Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
2020
A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax
2013
Delivery of Nucleic Acids via Disulfide‐Based Carrier Systems
2009
Effect of PEGylation on Biodistribution and Gene Silencing of siRNA/Lipid Nanoparticle Complexes
2012
Liposomal drug delivery systems: From concept to clinical applications
2012 Standout
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
2015 StandoutNobel
Knocking down barriers: advances in siRNA delivery
2009 Standout
Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
2021 StandoutNobel
Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
2020
Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
2018 StandoutNobel
DNA nanotechnology from the test tube to the cell
2015
Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA
2016
Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
2012
Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
2019
Advances in Lipid Nanoparticles for mRNA-Based Cancer Immunotherapy
2020
Endocytosis of nanomedicines
2010 Standout
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
Nanovector delivery of siRNA for cancer therapy
2012
Microfluidic self-assembly of folate-targeted monomolecular siRNA-lipid nanoparticles
2017
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening
2019
Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system
2016
Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA
2019
Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
2020
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
2014
High-throughput analysis of protein stability in polyanhydride nanoparticles
2010
Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery
2013
Influence of Polyethylene Glycol Chain Length on the Physicochemical and Biological Properties of Poly(ethylene imine)-graft-Poly(ethylene glycol) Block Copolymer/SiRNA Polyplexes
2006
Rational design of anti‐inflammatory lipid nanoparticles for mRNA delivery
2022 StandoutNobel
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
Nanomaterial Delivery Systems for mRNA Vaccines
2021 StandoutNobel
Ionizable Amino‐Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino‐Alcohols for Tissue Selective mRNA Delivery
2018
Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications
2010
Cross-Linked Microparticles as Carriers for the Delivery of Plasmid DNA for Vaccine Development
2004
Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes
2021
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
2023 StandoutNobel
Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery
2012
PEG-Assisted DNA Solubilization in Organic Solvents for Preparing Cytosol Specifically Degradable PEG/DNA Nanogels
2006
Development of Therapeutic Polymeric Nanoparticles for the Resolution of Inflammation
2014
Nanoparticles in the clinic
2016
Charge-Reversal Amphiphiles for Gene Delivery
2004
Gene Delivery Properties of End-Modified Poly(β-amino ester)s
2007
Transferrin-Appended Nanocaplet for Transcellular siRNA Delivery into Deep Tissues
2019
Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide
2019
Chemical modification of chitosan as a gene carrier in vitro and in vivo
2007
Optimization of a Degradable Polymer–Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells
2018
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
2015
Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model
2016
The great escape: how cationic polyplexes overcome the endosomal barrier
2018
Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature
2015
Lipidoid Tail Structure Strongly Influences siRNA Delivery Activity
2016
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
2010
Silica- and Alkoxysilane-Coated Ultrasmall Superparamagnetic Iron Oxide Particles: A Promising Tool To Label Cells for Magnetic Resonance Imaging
2006
Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
2023 StandoutNobel
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering
2020
Monomolecular DNA Nanoparticles for Intravenous Delivery of Genes
2005
Nucleic Acid Delivery: The Missing Pieces of the Puzzle?
2012
Mimicking the Cell: Bio-Inspired Functions of Supramolecular Assemblies
2015
Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA
2018
Intracellular Delivery and Trafficking Dynamics of a Lymphoma-Targeting Antibody–Polymer Conjugate
2012
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy
2020
Three decades of messenger RNA vaccine development
2019
A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes
2020
Advances in RNAi therapeutic delivery to leukocytes using lipid nanoparticles
2016
Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver
2020
Single Cell Kinetics of Intracellular, Nonviral, Nucleic Acid Delivery Vehicle Acidification and Trafficking
2005
Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics
2019
Novel Bioreducible Poly(amido amine)s for Highly Efficient Gene Delivery
2006
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Lipid Nanoparticle Spherical Nucleic Acids for Intracellular DNA and RNA Delivery
2021
Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses
2019
Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug
2013
Localized RNAi Therapeutics of Chemoresistant Grade IV Glioma Using Hyaluronan-Grafted Lipid-Based Nanoparticles
2015
State‐of‐the‐Art Design and Rapid‐Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery
2018
mRNA Vaccine Delivery Using Lipid Nanoparticles
2016
Nonviral Vectors for Gene Delivery
2008 Standout
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery
2022
A Single Methylene Group in Oligoalkylamine‐Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery
2016
Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver
2021
Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems
2015
Branched‐Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH
2019
Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression
2011
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells
2002
Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA
2017
Tools for translation: non-viral materials for therapeutic mRNA delivery
2017
Challenges of Storage and Stability of mRNA-Based COVID-19 Vaccines
2021
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
2022 StandoutScienceNobel
Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA
2016
Fusion-dependent formation of lipid nanoparticles containing macromolecular payloads
2019
Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals
2017
Trehalose Click Polymers Inhibit Nanoparticle Aggregation and Promote pDNA Delivery in Serum
2006
Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics
2020
Ionizable lipid nanoparticles for in utero mRNA delivery
2021 StandoutNobel
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
2018
Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium
2019
Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges
2013
Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
2016
New Poly(d -glucaramidoamine)s Induce DNA Nanoparticle Formation and Efficient Gene Delivery into Mammalian Cells
2004
Orthogonal Design of Experiments for Optimization of Lipid Nanoparticles for mRNA Engineering of CAR T Cells
2021
Preparation of polyethyleneimine nanogels via photo-Fenton reaction
2007
Silencing or Stimulation? siRNA Delivery and the Immune System
2011
Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment
2013
GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics
2018
Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid‐like nanoparticles resolves liver fibrosis
2015
Lipids and Lipid Derivatives for RNA Delivery
2021
Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
2016
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants
2019
Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications
2019
Advances in Lipid Nanoparticles for siRNA Delivery
2013
A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo
2020
Alnylam launches era of RNAi drugs
2018
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
2021 StandoutNobel
Biodegradable Polymeric Vectors for Gene Delivery to Human Endothelial Cells
2006
Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility
2018
Biodistribution and Pharmacokinetic Analysis of Paclitaxel and Ceramide Administered in Multifunctional Polymer-Blend Nanoparticles in Drug Resistant Breast Cancer Model
2008
Bioreducible Micelles Self-Assembled from Amphiphilic Hyperbranched Multiarm Copolymer for Glutathione-Mediated Intracellular Drug Delivery
2011
DOPC versus DOPE as a helper lipid for gene-therapies: molecular dynamics simulations with DLin-MC3-DMA
2020
Hyperbranched Poly(amino ester)s with Different Terminal Amine Groups for DNA Delivery
2006
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery
2021
Systemic Iron Homeostasis
2013
A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation
2018
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing ofAngptl3
2021
Recent advances in polymeric materials for the delivery of RNA therapeutics
2019
Shell-Sheddable Micelles Based on Dextran-SS-Poly(ε-caprolactone) Diblock Copolymer for Efficient Intracellular Release of Doxorubicin
2010
Fluorescence Correlation Spectroscopy Reveals Highly Efficient Cytosolic Delivery of Certain Penta-Arg Proteins and Stapled Peptides
2015
Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function
2019
Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation
2012
Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device
2021 StandoutNobel
Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications
2012 Standout
Nanoparticles for Imaging, Sensing, and Therapeutic Intervention
2014
Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes
2017
A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo
2020
Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters
2018
pH-Triggered Nanoparticle Mediated Delivery of siRNA to Liver Cells in Vitro and in Vivo
2013
Methacrylamide Polymers with Hydrolysis-Sensitive Cationic Side Groups as Degradable Gene Carriers
2006
Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccine Elicits Antibody Responses with Greater Durability and Breadth than MF59-Adjuvanted gB Protein Immunization
2020 StandoutNobel
Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling
2021
Cellular uptake of nanoparticles: journey inside the cell
2017 Standout
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
2023 StandoutNobel
An Acetal-Based PEGylation Reagent for pH-Sensitive Shielding of DNA Polyplexes
2007
Poly(glycoamidoamine)s for Gene Delivery. Structural Effects on Cellular Internalization, Buffering Capacity, and Gene Expression
2006
Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells
2022
Stabilization of Ostwald Ripening in Low Molecular Weight Amino Lipid Nanoparticles for Systemic Delivery of siRNA Therapeutics
2014
An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo
2015
Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo
2020
On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
2018
Nanomaterials for Therapeutic RNA Delivery
2020
Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo
2016
Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment
2015
Synthesis of Poly(β-amino ester)s with Thiol-Reactive Side Chains for DNA Delivery
2006
Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles
2018
Dendrimer‐Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I
2018
Works of Akin Akinc being referenced
CSF transthyretin neuroprotection in a mouse model of brain ischemia
2010
Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles
2013
In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR)
2010
Lipid-like materials for low-dose, in vivo gene silencing
2010
MicroRNAs 103 and 107 regulate insulin sensitivity
2011 Nature
Measuring the pH environment of DNA delivered using nonviral vectors: Implications for lysosomal trafficking
2002
Reversal of siRNA-mediated gene silencing in vivo
2018
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
2019
Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape
2013
An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema
2018
Identification of siRNA delivery enhancers by a chemical library screen
2015
Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy
2014
Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis
2004
Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway
2007 Nature
Assessing siRNA Pharmacodynamics in a Luciferase-expressing Mouse
2008
Heme Oxygenase-1 Is an Anti-Inflammatory Host Factor that Promotes Murine Plasmodium Liver Infection
2008
Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver
2009
Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo
2012
Exploiting Endocytosis for Nanomedicines
2013
Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells
2011
Unique Gene‐Silencing and Structural Properties of 2′‐Fluoro‐Modified siRNAs
2011
Structure/property studies of polymeric gene delivery using a library of poly(β-amino esters)
2004
Host Scavenger Receptor SR-BI Plays a Dual Role in the Establishment of Malaria Parasite Liver Infection
2008
Gene Silencing Activity of siRNAs with a Ribo-difluorotoluyl Nucleotide
2006
Targeting the Hepcidin Pathway with RNAi Therapeutics for the Treatment of Anemia
2011
Parallel Synthesis and Biophysical Characterization of a Degradable Polymer Library for Gene Delivery
2003
Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
2012
A polymer library approach to suicide gene therapy for cancer
2004
Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
2012
Synthesis of Poly(β-amino ester)s Optimized for Highly Effective Gene Delivery
2003
Combinatorial Approach to Determine Functional Group Effects on Lipidoid-Mediated siRNA Delivery
2010
Treatment of erythropoietin deficiency in mice with systemically administered siRNA
2012 StandoutNobel
5′‐(E)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates
2016