Citation Impact
Citing Papers
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response
2013 StandoutNobel
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
Diabetic patients with acute coronary syndromes in the UK: high risk and under treated. Results from the prospective registry of acute ischaemic syndromes in the UK (PRAIS-UK)
2005
Use of beta-blocker therapy in older patients after acute myocardial infarction in Ontario.
1999
Effects of metoprolol CR in patients with ischemic and dilated cardiomyopathy: The randomized evaluation of strategies for left ventricular dysfunction pilot study
2000
Acute Coronary Care in the Elderly, Part I
2007
Effects of Beta Blockade on Sudden Cardiac Death During Acute Myocardial Infarction and the Postinfarction Period
1997
Effects of metoprolol and carvedilol on cause-specific mortality and morbidity in patients with chronic heart failure—COMET
2005
Arrhythmias and mortality in congestive heart failure
1990
Use of carvedilol in chronic heart failure: Challenges in therapeutic management
1998
Effect of Beta Blockers, Particularly Carvedilol, on Reducing the Risk of Events After Acute Myocardial Infarction
2006
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study
2010 Standout
Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus
1997
Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations
2003
Carvedilol improves left ventricular function and symptoms in chronic heart failure: A double-blind randomized study
1995
Postinfarction Use of β-Blockers in Elderly Patients
1997
Implications of Diabetes in Patients With Acute Coronary Syndromes<subtitle>The Global Registry of Acute Coronary Events</subtitle>
2004
Meta-analysis of effect of beta-blocker therapy on mortality in patients with New York Heart Association class IV chronic congestive heart failure
2000
Effects of Beta-Adrenergic Blockade on Survival of Patients With Chronic Heart Failure
1997
The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure
1996 Standout
Analysis of Randomized Controlled Trials on the Effect of Magnitude of Heart Rate Reduction on Clinical Outcomes in Patients With Systolic Chronic Heart Failure Receiving Beta-Blockers
2008
Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction
1992 Standout
Prospects for Cardiovascular Research
2001 StandoutNobel
Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial
2008
Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice
1999
Temporal changes in the management and outcome of Canadian diabetic patients hospitalized for non–ST-elevation acute coronary syndromes
2011
Wound repair and regeneration
2008 StandoutNature
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>
2003 Standout
Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy
2004
Effects of beta blockers (atenolol or metoprolol) on heart rate variability after acute myocardial infarction
1994
Antiarrhythmic effect of carvedilol after acute myocardial infarction
2005
2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults
2009 Standout
β-adrenergic blockade in chronic heart failure: Principles, progress, and practice
1998
Passive epicardial containment prevents ventricular remodeling in heart failure
2000
Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction
1998 Standout
Heart Rate Reduction by If-Channel Inhibition and its Potential Role in Heart Failure with Reduced and Preserved Ejection Fraction
2009
Update on recent clinical trials in congestive heart failure
2000
Current evidence supporting the role of diuretics in heart failure: a meta analysis of randomised controlled trials
2002
The Role of Echocardiography in the Diagnosis and Management of Heart Failure
2003
Heart failure disease management: a critical review
1999
A prospective randomized trial of triage angiography in acute coronary syndromes ineligible for thrombolytic therapy
1998
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
2016 Standout
Successes and failures of current treatment of heart failure
1998
Effect of Carvedilol on Survival in Severe Chronic Heart Failure
2001 Standout
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
Resting Heart Rate in Cardiovascular Disease
2007 Standout
The Management of Chronic Heart Failure
1996
Anemia is an independent risk for mortality after acute myocardial infarction in patients with and without diabetes
2006
Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: A randomized, double-blind, placebo-controlled study
1994
Serum cholesterol and long-term prognosis in middle-aged men with myocardial infarction and angina pectoris: A 16-year follow-up of the Primary Prevention Study in Gateborg, Sweden
1997
The receptors and cells for mammalian taste
2006 StandoutNature
Time course of improvement in left ventricular function, mass and geometry in patients with congestive heart failure treated with beta-adrenergic blockade
1995
Long-term β-Blocker vasodilator therapy improves cardiac function in idiopathic dilated cardiomyopathy: A double-blind, randomized study of bucindolol versus placebo
1990
Evolving trends in the epidemiologic factors of heart failure: Rationale for preventive strategies and comprehensive disease management
1997
Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial
2003
Cancer immunotherapy comes of age
2011 StandoutNature
Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans
1999
Mechanism of Action of Beta-Blocking Agents in Heart Failure
1997
Relation between beta-adrenergic blocker use, various correlates of left ventricular function and the chance of developing congestive heart failure
1990
Pleiotropic effects of statin therapy: molecular mechanisms and clinical results
2008
Early invasive versus conservative strategies for unstable angina & non-ST-elevation myocardial infarction in the stent era
2006
Effects of metoprolol on heart rate variability in survivors of acute myocardial infarction
1993
Are we misunderstanding beta-blockers
2007
The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.
1998
Beneficial effects of metoprolol in heart failure associated with coronary artery disease: A randomized trial
1994
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
Pathophysiologic and pharmacologic rationales for clinical management of chronic heart failure with beta-blocking agents
1993
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
1999 Standout
Absence of a deleterious effect of calcium channel blockers in patients with left ventricular dysfunction after myocardial infarction: The SAVE study experience
1998
Diabetes mellitus, a predictor of morbidity and mortality in the studies of left ventricular dysfunction (SOLVD) trials and registry
1996
Heart Rate Lowering by Specific and Selective If Current Inhibition with Ivabradine
2004
Effects of short- and long-term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy
1994
Efficacy of angiotensin-converting enzyme inhibitors and beta-blockers in the management of left ventricular systolic dysfunction according to race, gender, and diabetic status
2003
Quantifying heterogeneity in a meta‐analysis
2002 Standout
Safety and efficacy of carvedilol in severe heart failure
1997
Drug prescriptions after acute myocardial infarction: Dosage, compliance, and persistence
2003
Double-Blind Placebo-Controlled Study of Ibopamine and Diagoxin in Patients With Mild to Moderate Heart Failure: Results of the Dutch of the Ibopamine Multicenter Trial (DIMT)
1993
Influence of heart rate, blood pressure, and beta-blocker dose on outcome and the differences in outcome between carvedilol and metoprolol tartrate in patients with chronic heart failure: results from the COMET trial
2005
Intensive Insulin Therapy in Critically Ill Patients
2001 Standout
Bias in meta-analysis detected by a simple, graphical test
1997 Standout
Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling
2000 Standout
Comparison of the Effects of AV Nodal Ablation Versus AV Nodal Modification in Patients with Congestive Heart Failure and Uncontrolled Atrial Fibrillation
1998
Evidence from family studies for autoimmunity in dilated cardiomyopathy
1994
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
2009 Standout
Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): Effects on mortality at 1 year
1995 Standout
Rationale and design of a randomized, double‐blind, placebo‐controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the I f Inhibitor Ivabradine Trial (SHIFT)
2009
Heart rate per se impacts cardiac function in patients with systolic heart failure and pacing: a pilot study
2009
Effect of Amiodarone on Clinical Status and Left Ventricular Function in Patients With Congestive Heart Failure
1996
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Double-Blind, Placebo-Controlled Study of the Long-term Efficacy of Carvedilol in Patients With Severe Chronic Heart Failure
1995
Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
1998 StandoutNobel
A Review of Carvedilol Arrhythmia Data in Clinical Trials
2005
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
2005 Standout
Effect of timolol on mortality and reinfarction after acute myocardial infarction: Prognostic importance of heart rate at rest
1986
Chronic Heart Failure in the United States
1998
Wall stress and patterns of hypertrophy in the human left ventricle.
1975 Standout
β-Blockers in Chronic Heart Failure
2003
Early and Delayed Consequences of β 2 -Adrenergic Receptor Overexpression in Mouse Hearts
2000
A systematic review of selective and non-selective beta blockers for prevention of vascular events in patients with acute coronary syndrome or heart failure.
2009
Bradycardia and the Role of β-Blockade in the Amelioration of Left Ventricular Dysfunction
2000
Evaluating the federal role in financing health-related research
1996 StandoutNobel
2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults
2009
Epinephrine-induced hypokalemia: The role of beta adrenoceptors
1986
Meta-analysis: β-Blocker Dose, Heart Rate Reduction, and Death in Patients With Heart Failure
2009
β-Adrenergic Receptor Blockade in Chronic Heart Failure
2000
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
2008 StandoutNobel
β-Adrenergic Receptor Signaling: An Acute Compensatory Adjustment—Inappropriate for the Chronic Stress of Heart Failure?
2000
Double-Blind, Placebo-Controlled Study of the Effects of Carvedilol in Patients With Moderate to Severe Heart Failure
1996
Assessing the quality of reports of randomised trials: implications for the conduct of meta-analyses.
1999
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Hormone-electrolyte interactions in the pathogenesis of lethal cardiac arrhythmias in patients with congestive heart failure: Basis of a new physiologic approach to control of arrhythmia
1986
Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer
1997 StandoutNobel
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2band dose-dependent requirement of H-2g7for diabetes in NOD mice
2008 StandoutNobel
Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure
2001 StandoutNobel
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
Beta blockade during and after myocardial infarction: An overview of the randomized trials
1985 Standout
Carvedilol Inhibits Clinical Progression in Patients With Mild Symptoms of Heart Failure
1996
Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients
2000 Standout
Beneficial Effects of Intravenous and Oral Carvedilol Treatment in Acute Myocardial Infarction
1997
Development and Prospective Validation of a Clinical Index to Predict Survival in Ambulatory Patients Referred for Cardiac Transplant Evaluation
1997
Negative Chronotropic Effect of β-Blockade Therapy Reduces Myocardial Oxygen Expenditure for Nonmechanical Work
1996
β2-Adrenergic Receptor Antagonists Protect Against Ventricular Fibrillation
1997
Heart Rate Variability
1996 Standout
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
2007 StandoutNobel
Beta-Adrenergic Blockade in Chronic Heart Failure
1998
Effect of propranolol after acute myocardial infarction in patients with congestive heart failure.
1986
Prognostic Value of Bisoprolol-Induced Hemodynamic Effects in Heart Failure During the Cardiac Insufficiency BIsoprolol Study (CIBIS)
1997
Inhibition of Adenylyl Cyclase by G iα
1993 StandoutScienceNobel
Declining incidence of ventricular fibrillation in myocardial infarction. Implications for the prophylactic use of lidocaine.
1992
Beta-adrenergic stimulation of the failing ventricle: a double-blind, randomized trial of sustained oral therapy with prenalterol.
1984
Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial
2005
Clinical Effects of β-Adrenergic Blockade in Chronic Heart Failure
1998
Glycometabolic State at Admission: Important Risk Marker of Mortality in Conventionally Treated Patients With Diabetes Mellitus and Acute Myocardial Infarction
1999
2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes
2014 Standout
Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart
1996
Prospective, Randomized Comparison of Effect of Long-Term Treatment With Metoprolol or Carvedilol on Symptoms, Exercise, Ejection Fraction, and Oxidative Stress in Heart Failure
1999
Immediate versus deferred beta-blockade following thrombolytic therapy in patients with acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI) II-B Study.
1991
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 StandoutNature
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
2001 StandoutScienceNobel
Influence of β -Blockers on Mortality in Chronic Heart Failure
2000
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Long-Term Heart Rate Reduction Induced by the Selective I f Current Inhibitor Ivabradine Improves Left Ventricular Function and Intrinsic Myocardial Structure in Congestive Heart Failure
2004
Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction
2000 StandoutNobel
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial
2010 Standout
Works of Åke Hjalmarson being referenced
Metoprolol in acute myocardial infarction
1985
Growth hormone improves cardiac function in rats with experimental myocardial infarction
1997
The epidemiology of a coronary waiting list A description of all of the patients
1994
Empiric Therapy with β‐Blockers
1994
Mortality and Morbidity During a Five‐year Follow‐up of Diabetics with Myocardial Infarction
1988
Effect of Metoprolol on the Prognosis for Patients With Suspected Acute Myocardial Infarction and Indirect Signs of Congestive Heart Failure (A Subgroup Analysis of the Göteborg Metoprolol Trial)
1997
Metoprolol-induced reduction in postinfarction mortality: pooled results from five double-blind randomized trials
1992
Increase in functional activity rather than in amount of Gi- in failing human heart with dilated cardiomyopathy
1992
Prognosis of Acute Myocardial Infarction in Diabetic and Non‐diabetic Patients
1993
Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy.
1990
What resting heart rate should one aim for when treating patients with heart failure with a beta-blocker?
2005
Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy
1993
Challenges of subgroup analyses in multinational clinical trials: Experiences from the MERIT-HF trial
2001
Improved exercise hemodynamic status in dilated cardiomyopathy after beta-adrenergic blockade treatment
1994
A statin in the treatment of heart failure? Controlled rosuvastatin multinational study in heart failure (CORONA): Study design and baseline characteristics
2005
Prevention of sudden cardiac death with beta blockers.
1999
Effects of work and acute beta‐receptor blockade on myocardial noradrenaline release in congestive cardiomyopathy
1979
A Double-Blind Trial of Metoprolol in Acute Myocardial Infarction
1983
Development of congestive heart failure after treatment with metoprolol in acute myocardial infarction.
1984
In Vitro Work Load and Rat Heart Metabolism
1972
Limitation of infarct size by beta blockers and its potential role for prognosis.
1983
Limitation of infarct size in acute myocardial infarction with metoprolol
1982
Long-term beta-blockade in dilated cardiomyopathy. Effects of short- and long-term metoprolol treatment followed by withdrawal and readministration of metoprolol.
1989
Myocardial infarction. Effects of beta-blockade.
1991
Significance of reduction in heart rate in cardiovascular disease.
1998
EFFECT ON MORTALITY OF METOPROLOL IN ACUTE MYOCARDIAL INFARCTION
1981
Clinical results with prenalterol in patients with heart failure
1981