Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels
1997
Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.
2000
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1
1996 StandoutNobel
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
1997
Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
2001
Hypoxia, a Novel Inducer of Acute Phase Gene Expression in a Human Hepatoma Cell Line
1995
Oxygen sensors and angiogenesis
2002 StandoutNobel
Activation of the HIF pathway in cancer
2001
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
2002
Hallmarks of Cancer: The Next Generation
2011 Standout
The Mouse Gene for Hypoxia‐Inducible Factor‐1α
1997
Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy
2010 StandoutNobel
HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin
2003
Oxygen sensing and response to hypoxia by mammalian cells
1996 StandoutNobel
Angiogenesis inhibition: A review
1994
Suppression of tumor growth through disruption of hypoxia-inducible transcription
2000 StandoutNobel
Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway
2002
Resident vascular progenitor cells: An emerging role for non-terminally differentiated vessel-resident cells in vascular biology
2008
Quantitative immunohistological analysis of the microvasculature in untreated human glioblastoma multiforme
1994
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α
2001
Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia.
1996
Regulation of Vascular Endothelial Growth Factor by Oxygen in a Model of Retinopathy of Prematurity
1996
Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells
1994
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
1999 Standout
Clinical translation of angiogenesis inhibitors
2002 Standout
The Mouse Gene for Vascular Endothelial Growth Factor
1996
How Tumors Become Angiogenic
1996
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
1996 Standout
Expression of Angiogenic Growth Factors in Paragangliomas
2000
Molecular mechanisms of blood vessel growth
2001
Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
1998
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
2010
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
1999
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
2002
Regulation of Human Vascular Endothelial Growth Factor mRNA Stability in Hypoxia by Heterogeneous Nuclear Ribonucleoprotein L
1999
Hypoxic Regulation of Lactate Dehydrogenase A
1995 StandoutNobel
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1)
2007
Endocrine gland–derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis
2002
Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids.
1996
Tumor angiogenesis: past, present and the near future
2000
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
2004 Standout
Expression of angiogenesis‐related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis
2001 StandoutNobel
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway
2002 StandoutNobel
Involvement of endothelial progenitor cells in tumor vascularization
2010
Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis
1999
New insights into nNOS regulation of vascular homeostasis
2005 StandoutNobel
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts.
1994
Development and Disease in Proteinase-Deficient Mice
1998
Angiostatin induces and sustains dormancy of human primary tumors in mice
1996
VEGF mRNA is Reversibly Stabilized by Hypoxia and Persistently Stabilized in VEGF-Overexpressing Human Tumor Cell Lines
1995
Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway
1998 Standout
Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
1997
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
1997 Nature
Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.
1994
Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells
1996
Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.
1995
Angiogenesis in cancer and other diseases
2000 StandoutNature
In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis
1999
The biology of VEGF and its receptors
2003 Standout
VEGF/VPF: The angiogenesis factor found?
1993
Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: A possible signal for vessel development
2001
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
2000 StandoutNobel
Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis
1998
Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia
1996
Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization
2007
Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis.
1997
Mechanisms of resistance to antiangiogenesis therapy
2010
Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells
1995
Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains
1995
Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity
2000 StandoutNobel
Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
1994 Nature
Protein Kinase C-β and Oxygen Deprivation
2000
Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells
1998
Pimonidazole: A Novel Hypoxia Marker for Complementary Study of Tumor Hypoxia and Cell Proliferation in Cervical Carcinoma
1998
Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy
2002
Cell adhesion and angiogenesis.
1997
Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit (HIF-1α)
1998 StandoutNobel
Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells
1998
Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine
1997
Vascular Endothelial Growth Factor: Molecular and Biological Aspects
1999
Corrupt policemen: inflammatory cells promote tumor angiogenesis
2008
Inhibition of Vascular Endothelial Growth Factor (VEGF)-induced Endothelial Cell Proliferation by a Peptide Corresponding to the Exon 7-Encoded Domain of VEGF165
1997
Vascular endothelial growth factor and its receptors
1996
Hypoxia-Inducible Angiopoietin-2 Expression Is Mimicked by Iodonium Compounds and Occurs in the Rat Brain and Skin in Response to Systemic Hypoxia and Tissue Ischemia
2000
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
HIF-1alpha is required for solid tumor formation and embryonic vascularization
1998
Characterisation of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines
1994 StandoutNobel
VEGF as a Key Mediator of Angiogenesis in Cancer
2005
Differential Endothelial Migration and Proliferation to Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor
1996
Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis
2010
A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology
2002
Tumor Induction of VEGF Promoter Activity in Stromal Cells
1998
Inhibition of Vascular Endothelial Growth Factor Prevents Retinal Ischemia—Associated Iris Neovascularization in a Nonhuman Primate
1996
Purification and Characterization of Hypoxia-inducible Factor 1
1995 StandoutNobel
Clinical Applications of Research on Angiogenesis
1995 Standout
Development of a hypoxia-responsive vector for tumor-specific gene therapy
2000
Molecular and biological properties of vascular endothelial growth factor
1999
Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders
1994 Standout
Defective Vascularization of HIF-1α-Null Embryos Is Not Associated with VEGF Deficiency but with Mesenchymal Cell Death
1999 StandoutNobel
Intramyocardial injection of naked DNA encoding HIF-1 /VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat
2002
Effect of Hyperoxia on Vascular Endothelial Growth Factor Levels in a Wound Model
2000
Hypoxia-Induced Vascular Endothelial Growth Factor Expression Precedes Neovascularization after Cerebral Ischemia
2000
VEGF and the quest for tumour angiogenesis factors
2002
Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF165 via Its Exon 7-encoded Domain
1996
Regulation of Vascular Endothelial Growth Factor Expression by Advanced Glycation End Products
2001
The multifaceted circulating endothelial cell in cancer: towards marker and target identification
2006
Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells
1999
Stem cells in tumor angiogenesis
2010
Progressive loss of sensitivity to endothelium‐derived growth inhibitors expressed by human melanoma cells during disease progression
1994
Molecular biology of erythropoietin
1993 StandoutNobel
Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis
1995
Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability
1995
p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1
1999
Targeting gene expression to hypoxic tumor cells
1997 StandoutNobel
Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia
1995
Vascular-specific growth factors and blood vessel formation
2000 StandoutNature
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
2010 StandoutNobel
Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.
1996
Mechanisms of angiogenesis
1997 StandoutNature
Elusive Identities and Overlapping Phenotypes of Proangiogenic Myeloid Cells in Tumors
2010
HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion
2008
Molecular Mechanisms of Developmental and Tumor Angiogenesis
1994
Stimulation and Inhibition of Angiogenesis in Diabetic Retinopathy
2001
Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1
1996 StandoutNobel
The SDF-1–CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis
2007
Vascular endothelial growth factor
1993
Transcriptional Regulation by Hypoxia-Inducible Factor 1 Molecular Mechanisms of Oxygen Homeostasis
1996 StandoutNobel
Structure, Expression and Receptor-Binding Properties of Novel Vascular Endothelial Growth Factors
1999
The role of vascular endothelial growth factor in blood vessel formation
1996
Transgenic mouse models in angiogenesis and cardiovascular disease
2000
Angiogenesis in cancer, vascular, rheumatoid and other disease
1995 Standout
Hypoxia and platelet‐derived growth factor‐BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells
1995
The angiogenic switch in carcinogenesis
2009
Mechanisms of angiogenesis and arteriogenesis
2000 Standout
Angiogenic Signalling Pathways
2008
Vascular endothelial growth factor is essential for corpus luteum angiogenesis
1998
Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR
1998
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection
2011 StandoutNobel
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
1996 StandoutNature
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
2007 Nature
Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 β in Rat Aortic Smooth Muscle Cells
1995
Early Wound Healing Exhibits Cytokine Surge Without Evidence of Hypoxia
2000
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
1998 StandoutNobel
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
2000
The anti-angiogenic basis of metronomic chemotherapy
2004 Standout
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
1995
Hypoxia-inducible Protein Binding to Vascular Endothelial Growth Factor mRNA and Its Modulation by the von Hippel-Lindau Protein
1996
Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes
1997
The Hypoxic Response: Huffing and HIFing
1997
Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine
1997
Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.
1995
Modes of resistance to anti-angiogenic therapy
2008 Standout
Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer
1998 StandoutNobel
Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors
1996
Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development
1995
The role of pericytes in blood-vessel formation and maintenance
2005
Tumor Angiogenesis
2008 Standout
Detection of Vascular Endothelial Growth Factor Messenger RNA and Vascular Endothelial Growth Factor-like Activity in Proliferative Diabetic Retinopathy
1994
Pericytes and vessel maturation during tumor angiogenesis and metastasis
2010
Tumorigenesis and the angiogenic switch
2003 Standout
Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy
1994
Insulin and Insulin-like Growth Factor-I Induce Vascular Endothelial Growth Factor mRNA Expression via Different Signaling Pathways
2000
Identification of Hypoxically Inducible mRNAs in HeLa Cells Using Differential‐Display PCR
1996 StandoutNobel
Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor
1998 Standout
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
1993 StandoutNature
Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
2000 StandoutNobel
Regulation of Vascular Endothelial Growth Factor in Cardiac Myocytes
1995
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
2000
Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-induced Proliferation of Endothelial Cells and Pericytes
1995
A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
1998 Standout
Vascular endothelial growth factor and its receptors
1994
Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression
2000
Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
2000
Differential signaling pathways ofHO-1gene expression in pulmonary and systemic vascular cells
1999
The well-tempered vessel
2001
Development of Monocytes, Macrophages, and Dendritic Cells
2010 StandoutScience
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
2000 StandoutNobel
Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein.
1996
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression
2000 StandoutNobel
Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
1998
Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis
2009
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.
1995
Endothelial receptor tyrosine kinases involved in angiogenesis.
1995
Angiogenesis in human coronary atherosclerotic plaques.
1994
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
1993 StandoutNobel
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
2007
Regulation of Human Placental Development by Oxygen Tension
1997 Science
Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia
1998
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.
1996
Molecular Mechanisms of Coronary Collateral Vessel Growth
1996
Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only.
1994
Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.
1995
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.
1998
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
1995 Standout
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
1997 StandoutScience
Vascular remodeling and clinical resistance to antiangiogenic cancer therapy
2004
Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase.
1999
Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
1997
Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport
2001
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells.
1997
Hypoxic stress proteins: Survival of the fittest
1996
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.
1994
Effects of Aging and Hypoxia-Inducible Factor-1 Activity on Angiogenic Cell Mobilization and Recovery of Perfusion After Limb Ischemia
2007 StandoutNobel
Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization.
1995
Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia
1997 StandoutNobel
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.
2000 StandoutNobel
Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression.
1999 StandoutNobel
Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells
1993
Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents
1995 StandoutNobel
The bone marrow constitutes a reservoir of pericyte progenitors
2006
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
1997
The Biology of Vascular Endothelial Growth Factor
1997 Standout
Correlation of high lactate levels in human cervical cancer with incidence of metastasis.
1995
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
1999 StandoutScience
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.
1996 Standout
Preclinical Safety Evaluation of rhuMAbVEGF, an Antiangiogenic Humanized Monoclonal Antibody
1999
Hypoxia Activates Multiple Transcriptional Pathways in Mouse Pheochromocytoma Cells
2002
Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate
1998
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
1996
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.
1999
Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
1999
Endocytosis and the recycling of plasma membrane.
1983 StandoutNobel
Increased Plasma Vascular Endothelial Growth Factor (VEGF) as a Surrogate Marker for Optimal Therapeutic Dosing of VEGF Receptor-2 Monoclonal Antibodies
2004
Impact of oncogenes in tumor angiogenesis: Mutant K- ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
1998
Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance
2001 StandoutNobel
Antiangiogenic Therapy: A Universal Chemosensitization Strategy for Cancer?
2006 Science
Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.
1993
Angiogenesis: Models and Modulators
1995
Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
1994
Covalent dimerization of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity. Evidence from Cys to Ser mutations
1994
Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox.
1999
Vascular Endothelial Growth Factor
2009 Standout
Differentiation of endothelium
1995
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.
2000
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.
1993
Human Erythropoietin Induces a Pro-Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo
1999
Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor
2002
Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors
2006 Science
VEGF Receptor Signal Transduction
2001
Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas.
1995
Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis
2001
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells.
1999
Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
2007
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Functional Upregulation of the Vascular Endothelial Growth Factor Receptor KDR by Hypoxia
1996
VEGF is required for growth and survival in neonatal mice
1999
Distinct effect of hypoxia on endothelial cell proliferation and cycling
1997
Placental growth factor is a survival factor for tumor endothelial cells and macrophages.
2002
Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors
1998
Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
1996
Hypoxia and radiation response in human tumors
1996
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
2009 StandoutNobel
Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1
1996 StandoutNobel
Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells.
1996
Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.
1996
An essential role for p300/CBP in the cellular response to hypoxia
1996
Hypoxia Stimulates Urokinase Receptor Expression Through a Heme Protein-Dependent Pathway
1998
Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor
1998
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
1999 StandoutNobel
Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.
1997
Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression.
1995
HIF-1 and human disease: one highly involved factor
2000 StandoutNobel
Angiogenesis in Endocrine Tumors
2003
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
2007
Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells
1995
Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.
1995 Standout
Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development
2005
Regulation of c-jun Expression during Hypoxic and Low-Glucose Stress
1994
Expression of hypoxia-inducible factor 1? in brain tumors
2000 StandoutNobel
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.
1996 Standout
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
1998 Standout
Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.
2000
Interindividual Heterogeneity in the Hypoxic Regulation of VEGF
1999
Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element
1997
Vascular endothelial growth factor (VEGF) and its receptors
1999 Standout
Hypoxic Induction of Endothelial Cell Growth Factors in Retinal Cells: Identification and Characterization of Vascular Endothelial Growth Factor (VEGF) as the Mitogen
1995
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
2004 Standout
Frequent Overexpression of Vascular Endothelial Growth Factor Gene in Human Renal Cell Carcinoma.
1994
The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy.
1996
Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model.
1994
Insulin-induced vascular endothelial growth factor expression in retina.
1999
Works of Ahuva Itin being referenced
Ero1-Lα plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer
2004
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
1992 StandoutNature
Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.
1993
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
1995 Standout
VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells
2006
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
1999
Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation
2007
Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia and Hypoglycemia and Coregulation with Other Ischemia-Induced Genes
1995
Purification of the insulin receptor from human placenta by chromatography on immobilized wheat germ lectin and receptor antibody.
1980
Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia
1998
Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity.
1996
Loss of ovarian function promotes angiogenesis in human ovarian carcinoma
1997
Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy.
1996
In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis.
1992
A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects
2001
Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
1995
Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.
1995
Vascular endothelial growth factor upregulation in human central retinal vein occlusion11The authors have no proprietary interest in any of the materials used in this study.
1998
Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis.
1990
Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases.
1995