Standout Papers
Citation Impact
Citing Papers
Mutations of the Drosophila dDP , dE2F , and cyclin E Genes Reveal Distinct Roles for the E2F-DP Transcription Factor and Cyclin E during the G 1 -S Transition
1998
TOR Signaling in Growth and Metabolism
2006 Standout
Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1
1996
Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
1997 Nature
From molecular to modular cell biology
1999 StandoutNatureNobel
E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila
1999
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
2005 StandoutNobel
MYC on the Path to Cancer
2012 Standout
Regulation of cell proliferation by the E2F transcription factors
1998
MicroRNAs
2004 Standout
A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27Kip1
1998
Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis
1990 Standout
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Mutations in Drosophila DP and E2F distinguish G1–S progression from an associated transcriptional program
1997
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins
1997
ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP
1999
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
2002 Standout
c-Myc-regulated microRNAs modulate E2F1 expression
2005 StandoutNature
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
1998 StandoutNobel
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins
1998
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis
2000 Standout
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Heterochronic Genes Control Cell Cycle Progress and Developmental Competence of C. elegans Vulva Precursor Cells
1996 StandoutNobel
Tissue-specific regulation ofcyclin Etranscription duringDrosophila melanogasterembryogenesis
2000
Asymmetry in the Assembly of the RNAi Enzyme Complex
2003 Standout
Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action
2002 Standout
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 Standout
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
2007 Standout
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP
2005 Standout
The regulation of E2F by pRB-family proteins
1998 Standout
Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression
2001 StandoutNobel
The Microprocessor complex mediates the genesis of microRNAs
2004 StandoutNature
Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5
2000 StandoutNobel
The Rb/E2F pathway: expanding roles and emerging paradigms
2000 Standout
Coordination of Growth and Cell Division in the Drosophila Wing
1998
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Principles of CDK regulation
1995 StandoutNature
bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila
2003 Standout
Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth
2005 StandoutNobel
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression
2000 StandoutNobel
Sibling rivalry in the E2F family
2002
The small RNA repertoire of Dictyostelium discoideum and its regulation by components of the RNAi pathway
2007 StandoutNobel
Growth Regulation by the E2F and DP Transcription Factor Families
1998
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
2000
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
2017 Standout
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia
2015
Endoreplication Cell Cycles
2001
The Small RNA Profile during Drosophila melanogaster Development
2003
Count-based differential expression analysis of RNA sequencing data using R and Bioconductor
2013
Stem cell-derived polarized hepatocytes
2020 StandoutNobel
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Cloning of Drosophila GCN5: Conserved features among metazoan GCN5 family members
1998
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Differential Control of Transcription by DNA-bound Cyclins
2001 StandoutNobel
Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells.
1996
Histologic Study of the Regeneration of Axillary Hair after Removal with Subcutaneous Tissue Shaver
1979
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.
1995
Cancer Cell Cycles
1996 StandoutScience
Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs.
1996
Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence
2003 Standout
A Genetic Screen for Modifiers of E2F in Drosophila melanogaster
1999
CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase
1999
RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.
1996
Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase.
1996
Developmental control of a G1-S transcriptional program in Drosophila
1994
Differential regulation of E2F transactivation by cyclin/cdk2 complexes.
1994
c-Myc Overexpression Uncouples DNA Replication from Mitosis
1999
Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.
1995
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
1997 Standout
The retinoblastoma protein and cell cycle control
1995 Standout
Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes
1999 StandoutNobel
Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein
1998
Cyclin E-induced S phase without activation of the pRb/E2F pathway.
1997
Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G1
1996
Arabidopsis Transcription Factors: Genome-Wide Comparative Analysis Among Eukaryotes
2000 StandoutScience
Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms
1998
Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster
1995
Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye.
1996
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Involvement of Myc Activity in a G1/S-Promoting Mechanism Parallel to the pRb/E2F Pathway
2000
Developmental Control of Cell Cycle Regulators: A Fly's Perspective
1996 Science
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.
1997
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
2013 Standout
Cell Cycle-Regulated Association of E2F1 and Sp1 Is Related to Their Functional Interaction
1996
Works of A.H. Brook being referenced
Savant Genome Browser 2: visualization and analysis for population-scale genomics
2012
Multilevel complex interactions between genetic, epigenetic and environmental factors in the aetiology of anomalies of dental development
2009
Neogenesis of Wool Follicles
1964
E2F-induced S phase requires cyclin E.
1996
DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.
1994