Citation Impact
Citing Papers
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
2004 StandoutScience
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor
2001 StandoutNobel
Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
2003
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
The amyloid precursor protein: beyond amyloid.
2006
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Hypoxia Requires Notch Signaling to Maintain the Undifferentiated Cell State
2005
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease
2005
Therapeutic strategies for Alzheimer's disease
2002
The Lipoprotein Receptor LR11 Regulates Amyloid β Production and Amyloid Precursor Protein Traffic in Endosomal Compartments
2006
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Deregulated NOTCH Signaling in Acute T-Cell Lymphoblastic Leukemia/Lymphoma: New Insights, Questions, and Opportunities
2005
The Value of Transgenic Models for the Study of Neurodegenerative Diseases
2000
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011 Standout
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
mRNA Is an Endogenous Ligand for Toll-like Receptor 3
2004 StandoutNobel
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
2002
Regulation of Notch signalling by non-visual β-arrestin
2005
aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation
2002
T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling
2004
The Cell Adhesion Protein P-selectin Glycoprotein Ligand-1 Is a Substrate for the Aspartyl Protease BACE1
2003
βAPP and Furin mRNA Concentrates in Immature Senile Plaques in the Brain of Alzheimer Patients
2002
Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme
2000
BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
2001
Putative function of ADAM9, ADAM10, and ADAM17 as APP -secretase
2003
The C-terminal PDZ-Ligand of JAGGED1 Is Essential for Cellular Transformation
2003
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
Regulated Intramembrane Proteolysis
2000
β‐Site APP cleaving enzyme up‐regulation induced by 4‐hydroxynonenal is mediated by stress‐activated protein kinases pathways
2005
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice
2007
Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain
2003
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
A common enzyme connects Notch signaling and Alzheimer's disease
2000
Aβ-Generating Enzymes
2000
Post-translational Processing of β-Secretase (β-Amyloid-converting Enzyme) and Its Ectodomain Shedding
2001
Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
2000
Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Aβ-like Peptide
2002
Notch signalling: a simple pathway becomes complex
2006 Standout
X11α and X11β Interact with Presenilin-1 via Their PDZ Domains
2000
Protein Degradation: Four E3s For The Notch Pathway
2002
The Role of Presenilins in γ-Secretase Activity
2001
Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins
2000
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
2001
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos
2006
MAX2 participates in an SCF complex which acts locally at the node to suppress shoot branching
2007
Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta
2003
Phosphorylation Regulates Intracellular Trafficking of β-Secretase
2001
Energy Inhibition Elevates β-Secretase Levels and Activity and Is Potentially Amyloidogenic in APP Transgenic Mice: Possible Early Events in Alzheimer's Disease Pathogenesis
2005
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Oncogenic aberrations of cullin-dependent ubiquitin ligases
2004
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Synaptotagmins: Why So Many?
2002 StandoutNobel
Expression of human β‐secretase in the mouse brain increases the steady‐state level of β‐amyloid
2002
Multiple Effects of Aspartate Mutant Presenilin 1 on the Processing and Trafficking of Amyloid Precursor Protein
2001
Tannic Acid Is a Natural β-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice
2012
Immature nicastrin stabilizes APH‐1 independent of PEN‐2 and presenilin: identification of nicastrin mutants that selectively interact with APH‐1
2004
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Concentration-Dependent Modulation of Amyloid-β in Vivo and in Vitro Using the γ-Secretase Inhibitor, LY-450139
2006
A Loss of Function Mutant of the Presenilin Homologue SEL-12 Undergoes Aberrant Endoproteolysis in Caenorhabditis elegans and Increases Aβ42 Generation in Human Cells
2000
Dynamics of Aβ Turnover and Deposition in Different β-Amyloid Precursor Protein Transgenic Mouse Models Following γ-Secretase Inhibition
2008
Variations on the Notch pathway in neural development
2002
Neurofibrillary Tangles Mediate the Association of Amyloid Load With Clinical Alzheimer Disease and Level of Cognitive Function
2004
Substrate and Inhibitor Profile of BACE (β-Secretase) and Comparison with Other Mammalian Aspartic Proteases
2002
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Characterization of α2,6-Sialyltransferase Cleavage by Alzheimer's β-Secretase (BACE1)
2003
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
α‐secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation
2009
Genetically engineered mouse models of neurodegenerative diseases
2002
Strigolactone inhibition of shoot branching
2008 StandoutNature
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1
2004
The ubiquitin ligaseDrosophilaMind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
2005
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY
2005
One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering
2013 StandoutScience
Receptor regulation: β-arrestin moves up a notch
2005 StandoutNobel
Accelerated A Deposition in APPswe/PS1 E9 Mice with Hemizygous Deletions of TTR (Transthyretin)
2007
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
The molecular logic of Notch signaling – a structural and biochemical perspective
2008
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Genetic Analysis of Caenorhabditis elegans glp-1 Mutants Suggests Receptor Interaction or Competition
2003
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
2005 StandoutScience
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Notch: a membrane-bound transcription factor
2002
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes
2003
Novel TCR-Mediated Mechanisms of Notch Activation and Signaling
2017
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Cancer Genome Landscapes
2013 StandoutScience
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
2003 StandoutScience
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α
2011
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
2010
Apolipoprotein E ε4 allele, AD pathology, and the clinical expression of Alzheimer’s disease
2003
Receptor regulation: β-arrestin moves up a notch
2005 StandoutNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation
2010
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
The interplay between DSL proteins and ubiquitin ligases in Notch signaling
2005
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
Regulation of Notch Signaling Activity
2004
Works of Adele M. Pauley being referenced
The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog
2001
Direct interaction of soluble human recombinant tau protein with Aβ 1–42 results in tau aggregation and hyperphosphorylation by tau protein kinase II
2002
Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
1999 Nature
Positive and Negative Regulation of the γ-Secretase Activity by Nicastrin in a Murine Model
2003
SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation
2001