Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
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Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus
2006
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CD22: A Multifunctional Receptor That Regulates B Lymphocyte Survival and Signal Transduction
2005
Achievements and challenges of sialic acid research
2000
Functional diversity of helper T lymphocytes
1996 StandoutNature
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2006
The Mast Cell as a Source of Cytokines in Asthma
1996
Sialic Acids in Molecular and Cellular Interactions
1997
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation
1999
Siglecs and their roles in the immune system
2007 Standout
Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
2014
Constitutively unmasked CD22 on B cells of ST6Gal I knockout mice: novel sialoside probe for murine CD22
2002
Chemokines and leukocyte traffic
1998 StandoutNature
Characterization of the Sialic Acid-binding Site in Sialoadhesin by Site-directed Mutagenesis
1996
CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms
2004
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Associations of genetic polymorphisms of Siglecs with human diseases
2014
I-type lectins
2002
Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice.
1995
Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling
2005
Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cells
2004
The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9
2016
Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part II)
1994
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions
2012
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
2009 StandoutNature
Sialoside Specificity of the Siglec Family Assessed Using Novel Multivalent Probes
2003
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2
2001
CD22 is a negative regulator of B-cell receptor signalling
1997 Nobel
Cloning, Characterization, and Phylogenetic Analysis of Siglec-9, a New Member of the CD33-related Group of Siglecs
2000
Increased association of Trypanosoma cruzi with sialoadhesin positive mice macrophages
2005
Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.
1991
Mast Cell Chemotaxis – Chemoattractants and Signaling Pathways
2012
Functional groups of sialic acids involved in binding to siglecs (sialoadhesins) deduced from interactions with synthetic analogues
1998
Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins
2007 Nature
Potent Glycan Inhibitors of Myelin-associated Glycoprotein Enhance Axon Outgrowth in Vitro
2005
Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part I)
1994
Loss of N-Glycolylneuraminic Acid in Human Evolution
2000
The development of allergic inflammation
2008 StandoutNature
Versatile Biosynthetic Engineering of Sialic Acid in Living Cells Using Synthetic Sialic Acid Analogues
2002
Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load
2004
Regulation of B cell development and B cell signalling by CD22 and its ligands α2,6-linked sialic acids
2006
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 StandoutNature
Siglecs, sialic acids and innate immunity
2001
Crystal structures of murine polyomavirus in complex with straight-chain and branched-chain sialyloligosaccharide receptor fragments
1996
Proteasome inhibition: A novel mechanism to combat asthma☆☆☆
1999
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor
2003
Innate immune response mechanisms in the intestinal epithelium: potential roles for mast cells and goblet cells in the expulsion of adultTrichinella spiralis
2008
Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and resolution of inflammation following treatment with IL-12
2001
Structure-Guided Design of Sialic Acid-Based Siglec Inhibitors and Crystallographic Analysis in Complex with Sialoadhesin
2003
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
2009 StandoutNature
The murine inhibitory receptor mSiglec‐E is expressed broadly on cells of the innate immune system whereas mSiglec‐F is restricted to eosinophils
2004
Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.
1997
OB-BP1/Siglec-6
1999
The Sialoadhesins ? A family of sialic acid-dependent cellular recognition molecules within the immunoglobulin superfamily
1996
Conversion of cellular sialic acid expression from N-acetyl- to N-glycolylneuraminic acid using a synthetic precursor, N-glycolylmannosamine pentaacetate: inhibition of myelin-associated glycoprotein binding to neural cells
2000
Siglec-9, a Novel Sialic Acid Binding Member of the Immunoglobulin Superfamily Expressed Broadly on Human Blood Leukocytes
2000
Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0
2006
CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress
2013
lec32 Is a New Mutation in Chinese Hamster Ovary Cells That Essentially Abrogates CMP-N-acetylneuraminic Acid Synthetase Activity
1995
Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22
1994
Synovial mast cells: role in acute and chronic arthritis
2007
The sialoadhesin (CD169) expressing a macrophage subset in human proliferative glomerulonephritis
2005
Siglecs in innate immunity
2005
Molecular Cloning of MIS, a Myeloid Inhibitory Siglec, That Binds Protein-tyrosine Phosphatases SHP-1 and SHP-2
2001
Carbohydrate recognition systems: functional triads in cell—cell interactions
1996
Identification of an Alveolar Macrophage-derived Activity in Bronchial Asthma that Enhances Leukotriene C 4 Generation by Human Eosinophils Stimulated by lonophore A23187 as a Granulocyte-macrophage Colony-stimulating Factor
1989
Eosinophils: Biology and Role in Disease
1995
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
2010 StandoutNature
Multifarious roles of sialic acids in immunity
2012
The Amino-terminal Immunoglobulin-like Domain of Sialoadhesin Contains the Sialic Acid Binding Site
1995
Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily
2000
Crystal Structure of the N-Terminal Domain of Sialoadhesin in Complex with 3′ Sialyllactose at 1.85 Å Resolution
1998
Inhibitory Effect of the TRFK-5 Anti-IL-5 Antibody in a Guinea Pig Model of Asthma
1993
Inhibition of eosinophil chemotaxis by chronic blockade of nitric oxide biosynthesis
1996
Azido Sialic Acids Can Modulate Cell‐Surface Interactions
2004 StandoutNobel
The Human Condition—A Molecular Approach
2014 StandoutNobel
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Constitutively hyposialylated human T-lymphocyte clones in the Tn-syndrome: binding characteristics of plant and animal lectins
1996
A Novel Unsupervised Method to Identify Genes Important in the Anti-viral Response: Application to Interferon/Ribavirin in Hepatitis C Patients
2007
I-type Lectins
1995
Multiple changes in sialic acid biology during human evolution
2008
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Increasing diversity of animal lectin structures
1995
Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma
1992 Standout
Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation
2007
The role of T lymphocytes in the pathogenesis of asthma
2003
Siglecs—the major subfamily of I-type lectins
2005
T-Cell-mediated Induction of Airway Hyperreactivity in Mice
1991
Cytokines as Mediators of Chronic Asthma
1994
Macrophage–tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter‐receptor for the macrophage‐restricted receptor, sialoadhesin
1999
Localization of the Putative Sialic Acid-binding Site on the Immunoglobulin Superfamily Cell-surface Molecule CD22
1996
Cell-specific Glycoforms of Sialoadhesin and CD45 Are Counter-receptors for the Cysteine-rich Domain of the Mannose Receptor
1999
Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus
2004 StandoutNobel
Recognition of sialylated meningococcal lipopolysaccharide by siglecs expressed on myeloid cells leads to enhanced bacterial uptake
2003
Sialic Acid-Binding Immunoglobulin-Like Lectin 7 Mediates Selective Recognition of Sialylated Glycans Expressed on Campylobacter jejuni Lipooligosaccharides
2006
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound
2002
CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics
1997
Chemical Glycobiology
2001 StandoutScienceNobel
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP- N - acetylgalactosamine, and UDP-galactose
2001 StandoutNobel
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
1997 StandoutNobel
Involvement of Sialoadhesin in Entry of Porcine Reproductive and Respiratory Syndrome Virus into Porcine Alveolar Macrophages
2003
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
1998 StandoutScience
Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition
1998 Standout
Sialic acid binding receptors (siglecs) expressed by macrophages
1999
A Self-Assembled Multivalent Pseudopolyrotaxane for Binding Galectin-1
2004 StandoutNobel
Viewing Siglecs through the lens of tumor immunology
2017
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Why mammalian cell surface proteins are glycoproteins
1996
Porcine Arterivirus Infection of Alveolar Macrophages Is Mediated by Sialic Acid on the Virus
2004
The activation antigen CD69
1994 StandoutNobel
Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils
1997 StandoutNobel
Intracellular Functions of N-Linked Glycans
2001 StandoutScience
Cutting Edge: CD43 Functions as a T Cell Counterreceptor for the Macrophage Adhesion Receptor Sialoadhesin (Siglec-1)
2001
Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors
2006
Investigating Cellular Metabolism of Synthetic Azidosugars with the Staudinger Ligation
2002 StandoutNobel
Identification and Characterization of a Novel Siglec, Siglec-7, Expressed by Human Natural Killer Cells and Monocytes
1999
Human Rhinoviruses Inhibit the Accessory Function of Dendritic Cells by Inducing Sialoadhesin and B7-H1 Expression
2005
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis
2004
Metabolic incorporation of unnatural sialic acids into Haemophilus ducreyi lipooligosaccharides
2003 StandoutNobel
A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP
1995 Science
Decoding the Patterns of Self and Nonself by the Innate Immune System
2002 StandoutScience
High-Affinity Ligand Probes of CD22 Overcome the Threshold Set by cis Ligands to Allow for Binding, Endocytosis, and Killing of B Cells
2006
Imaging the glycome
2008 StandoutNobel
Interleukin-13: Central Mediator of Allergic Asthma
1998 StandoutScience
Inactivation of CMP- N -acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution
2002 StandoutNobel
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes
1998
Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag
2011 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design
2006
Interleukin-5, eosinophils, and disease
1992 Standout
Chemically Defined Sialoside Scaffolds for Investigation of Multivalent Interactions with Sialic Acid Binding Proteins†
2003 StandoutNobel
The Simian Immunodeficiency Virus ΔnefVaccine, after Application to the Tonsils of Rhesus Macaques, Replicates Primarily within CD4+T Cells and Elicits a Local Perforin-Positive CD8+T-Cell Response
2002 StandoutNobel
Siglec‐1 and ‐2 as potential biomarkers in autoimmune disease
2016
Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis
1997 StandoutScienceNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Animal Lectins
1997
Works of Adele Hartnell being referenced
CD69 is expressed by human eosinophils activated in vivo in asthma and in vitro by cytokines.
1993
Sialoadhesin (Sn) Maps to Mouse Chromosome 2 and Human Chromosome 20 and Is Not Linked to the Other Members of the Sialoadhesin Family, CD22, MAG, and CD33
1995
Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily
1994
The potential role of sialoadhesin as a macrophage recognition molecule in health and disease
1997
Modulation of human eosinophil chemotaxis and adhesion by anti‐allergic drugsin vitro
1993
The species‐specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin‐positive macrophages occur in the perifollicular zone, but not in the marginal zone
1997
Effects of Cetirizine on Human Eosinophil and Neutrophil Activation in vitro
1991
T Lymphocytes and Eosinophils in Allergen-induced Late-phase Asthmatic Reactions in the Guinea Pig
1990
Receptor expression and functional status of cultured human eosinophils derived from umbilical cord blood mononuclear cells
1990
Differential Regulation of Eosinophil Chemokine Signaling Via CCR3 and Non-CCR3 Pathways
1999
IFN-gamma induces expression of Fc gamma RIII (CD16) on human eosinophils.
1992
Fc gamma and CD11/CD18 receptor expression on normal density and low density human eosinophils.
1990
Interleukin-3-induced up-regulation of CR3 expression on human eosinophils is inhibited by dexamethasone.
1992
Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent
1991
Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness.
1993
Expression of mRNA and immunoreactivity for the granulocyte/macrophage colony-stimulating factor in activated human eosinophils.
1991
Sialoadhesin and related cellular recognition molecules of the immunoglobulin superfamily
1996
Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations
2001
Chemotactic action of prostaglandin E2on mouse mast cells acting via the PGE2receptor 3
2007
Tumor Necrosis Factor α-Induced Eosinophil Accumulation in Rat Skin Is Dependent on α4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways
1997
Chemotactic factor-induced low density neutrophils express enhanced complement (CR1 and CR3) receptors and increased complement-dependent cytotoxicity.
1987
IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner.
1990
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors
2005
The effects of eosinophil activating factor on IgG-dependent sulphidopeptide leukotriene generation by human eosinophils.
1986