Citation Impact
Citing Papers
Developmental Exposure to Estradiol and Bisphenol A Increases Susceptibility to Prostate Carcinogenesis and Epigenetically Regulates Phosphodiesterase Type 4 Variant 4
2006
Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
2005 StandoutNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
2012 StandoutNobel
PDE4 cAMP-specific phosphodiesterases
2001
p130Cas as a New Regulator of Mammary Epithelial Cell Proliferation, Survival, and HER2-Neu Oncogene–Dependent Breast Tumorigenesis
2006
Gene expression profiling predicts clinical outcome of breast cancer
2002 StandoutNature
Re-establishing immunological self-tolerance in autoimmune disease
2012 StandoutNobel
Differential Membrane Localization of ERas and Rheb, Two Ras-related Proteins Involved in the Phosphatidylinositol 3-Kinase/mTOR Pathway
2005 StandoutNobel
Rap1 signalling: adhering to new models
2001
TCR zeta chain lacking exon 7 in two patients with systemic lupus erythematosus
1998
Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer
2006 Standout
Multiple Elements Jointly Determine Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases 4 and 7
2005
Age‐related accumulation of LFA‐1high cells in a CD8+CD45RAhigh T cell population
1993
Age-related changes in lymphocyte development and function
2004
Elevated temperature regulates tumor necrosis factor‐mediated immune killing
1989
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function
2004 StandoutNobel
Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α
2007 StandoutNobel
Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
2005 Standout
A phase II study in advanced gastro-esophageal cancer using epirubicin and cisplatin in combination with continuous infusion 5-fluorouracil (ECF)
1994
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
2006 Standout
An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways
2011
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
2007 StandoutNobel
T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms
1998
Esophageal Cancer
2003 Standout
The Involvement of the Intestinal Microflora in theExpansion of CD4+ T Cells with a‐Naive Phenotype inthe Periphery
1992
The Development of Functionally Responsive T Cells
1992
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
1989 Nature
The next generation of PDE4 inhibitors
2001
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
2001 StandoutNobel
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
2002 Standout
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
An essential role for Scurfin in CD4+CD25+ T regulatory cells
2003 StandoutNobel
Cig30 and Pitx3 Genes Are Arranged in a Partially Overlapping Tail-to-Tail Array Resulting in Complementary Transcripts
1999
T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor ? chain messenger RNA
2001
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
1998 Standout
The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.
1992 StandoutNobel
CD44 and Its Interaction with Extracellular Matrix
1993
SEK1/MKK4 Is Required for Maintenance of a Normal Peripheral Lymphoid Compartment but Not for Lymphocyte Development
1998
Stem cells, ageing and the quest for immortality
2006 StandoutNature
Adhesion receptors of the immune system
1990 StandoutNature
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
1999 StandoutNature
POU domain family values: flexibility, partnerships, and developmental codes.
1997
PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis
2005
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
1991 StandoutNature
Ras and relatives—job sharing and networking keep an old family together
2002
Cyclic nucleotide phosphodiesterases
2001
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
2013 Standout
Mammalian MAP kinase signalling cascades
2001 StandoutNature
Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes
2004
Cross-talk between calcium and cAMP-dependent intracellular signaling pathways. Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells.
1995 StandoutNobel
T cell receptor antagonist peptides induce positive selection
1994 Standout
The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis
2004
Biological determinants of endocrine resistance in breast cancer
2009
Integrins
2002 Standout
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Frailty in elderly people
2013 Standout
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
1993 Standout
Cyclic AMP counteracts mitogen‐induced inositol phosphate generation and increases in intracellular Ca2+ concentrations in human lymphocytes
1991
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
2005 Standout
Positive and Negative Selection of T Cells
2003
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
Fluorine in medicinal chemistry
2007 Standout
Phosphodiesterase 7A-Deficient Mice Have Functional T Cells
2003
Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site
1997 StandoutScience
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
1999 StandoutNobel
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Repeated observation of breast tumor subtypes in independent gene expression data sets
2003 Standout
The Aging Immune System: Primer and Prospectus
1996 Science
Naive and memory T cells show distinct pathways of lymphocyte recirculation.
1990
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
2001 StandoutScience
Activation and differentiation requirements of primary T cells in vitro.
1993 StandoutNobel
Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ
2002 StandoutNobel
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Cholera toxin modulation of angiotensin II-stimulated inositol phosphate production in cultured vascular smooth muscle cells
1990
A Targeted Mutation at the T-Cell Receptor α/δ Locus Impairs T-Cell Development and Reveals the Presence of the Nearby Antiapoptosis Gene Dad1
1997
Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance
2002 StandoutNobel
Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells
2003
Turnover of naive- and memory-phenotype T cells.
1994
CD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha-beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells.
1994
Functional characterization of the human phosphodiesterase 7A1 promoter
2003
Immunological Memory and Protective Immunity: Understanding Their Relation
1996 StandoutScience
Widespread recombinase expression using FLPeR (Flipper) mice
2000
Constitutive class I-restricted exogenous presentation of self antigens in vivo.
1996 StandoutNobel
Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes
1999 StandoutNobel
CD1 Recognition by Mouse NK1 + T Lymphocytes
1995 StandoutScience
Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1
1994 StandoutNobel
Works of Adam Lerner being referenced
Human genomic sequences corresponding to murine CD3η‐related transcripts: Lack of conservation or expression of homologous human products
1992
p130Cas Regulates the Activity of AND-34, a Novel Ral, Rap1, and R-Ras Guanine Nucleotide Exchange Factor
2000
Etoposide, doxorubicin, and cisplatin chemotherapy for advanced gastric adenocarcinoma: results of a phase II trial.
1992
The cAMP Signaling Pathway as a Therapeutic Target in Lymphoid Malignancies
2000
PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP
2002
Pgp‐1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A
1989
Differential regulation of T-cell receptor processing and surface expression affected by CD3 theta, an alternatively spliced product of the CD3 zeta/eta gene locus.
1992
Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.
1994
Type 4 Cyclic Adenosine Monophosphate Phosphodiesterase as a Therapeutic Target in Chronic Lymphocytic Leukemia
1998
Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis
2003
AND-34 Activates Phosphatidylinositol 3-Kinase and Induces Anti-Estrogen Resistance in a SH2 and GDP Exchange Factor–Like Domain-Dependent Manner
2005
Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.
2002
AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter.
2003
PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A
2003
Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. II. Novel immunotherapy of B16 melanomas by local and systemic adoptive transfer.
1987
Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death.
1996
T-cell-receptor isoforms.
1992
Cyclic AMP concentrations modulate both calcium flux and hydrolysis of phosphatidylinositol phosphates in mouse T lymphocytes.
1988
Type 4 Cyclic Adenosine Monophosphate Phosphodiesterase as a Therapeutic Target in Chronic Lymphocytic Leukemia
1998
CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1.
1993