Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
BRCA1-Associated Epigenetic Regulation of p73 Mediates an Effector Pathway for Chemosensitivity in Ovarian Carcinoma
2010
Tumour-cell invasion and migration: diversity and escape mechanisms
2003 Standout
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
2012 Nature
Hallmarks of Cancer: The Next Generation
2011 Standout
Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 axis and JNK-dependent inhibition of glucose metabolism
2014
Biologic and therapeutic role of HER2 in cancer
2003
DNA Damage Promotes Histone Deacetylase 4 Nuclear Localization and Repression of G2/M Promoters, via p53 C-terminal Lysines
2005
Multiple Stress Signals Induce p73β Accumulation
2004
The DNA-damage response in human biology and disease
2009 StandoutNature
Mdm2 promotes the rapid degradation of p53
1997 StandoutNature
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia
2009
Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion
1997
The p53 and Mdm2 families in cancer
2002
β-Arrestin Is Crucial for Ubiquitination and Down-regulation of the Insulin-like Growth Factor-1 Receptor by Acting as Adaptor for the MDM2 E3 Ligase
2005 StandoutNobel
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
2012 StandoutNature
p53 is a NF‐Y‐ and p21‐independent, Sp1‐dependent repressor of cyclin B1 transcription
2005
Repression of New p53 Targets Revealed by ChIP on Chip Experiments
2006
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
2009
p53 in growth control and neoplasia
1996
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
2001
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
p53 — a Jack of all trades but master of none
2009
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
The p53 family in differentiation and tumorigenesis
2007
Rescuing the function of mutant p53
2001
E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation
2006
When Checkpoints Fail
1997 StandoutNobel
p21/CDKN1A Mediates Negative Regulation of Transcription by p53
2003
Involvement of chemokine receptors in breast cancer metastasis
2001 StandoutNature
The Breast Cancer β4 Integrin and Endothelial Human CLCA2 Mediate Lung Metastasis
2001
The IARC TP53 database: New online mutation analysis and recommendations to users
2002
The Hallmarks of Cancer
2000 Standout
Integrins and cancer
1996
Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)
2008
DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes
2002
The Hippo Signaling Pathway in Development and Cancer
2010 Standout
DNA Damage-Induced Downregulation of Cdc25C Is Mediated by p53 via Two Independent Mechanisms
2004
Blinded by the Light: The Growing Complexity of p53
2009 Standout
The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP
2005 Standout
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Functions of MDMX in the Modulation of the p53‐Response
2011
Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo.
1997
The dark side of a tumor suppressor: anti-apoptotic p53
2008
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
Protein folding and misfolding
2003 StandoutNature
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1
1998
Adhesion receptors of the immune system
1990 StandoutNature
Reactivation of mutant p53: molecular mechanisms and therapeutic potential
2007
EMT, the cytoskeleton, and cancer cell invasion
2009
p53 mediates the negative regulation of MDM2 by orphan receptor TR3
2006
Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells
2004
Live or let die: the cell's response to p53
2002 Standout
Human ΔNp73 regulates a dominant negative feedback loop for TAp73 and p53
2001
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
2007
Autoregulatory control of the p53 response by caspase‐mediated processing of HIPK2
2006
Ageing and telomeres: a study into organ- and gender-specific telomere shortening
2003
Tissue-specific expression and regulation of sexually dimorphic genes in mice
2006
The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers
2007
The opposing roles of laminin-binding integrins in cancer
2016
Transcription repression of a CCAAT-binding transcription factor CBF/HSP70 by p53
2005
Genome-Wide In Silico Identification of Transcriptional Regulators Controlling the Cell Cycle in Human Cells
2003
The Hallmarks of Aging
2013 Standout
Role of the newer p53 family proteins in malignancy
2001 StandoutNobel
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
2006
p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor
2001
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
2011 StandoutNature
Cell Cycle-dependent Regulation of the Cyclin B1 Promoter
1995
Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family
2005
p53 alterations in human cancer: more questions than answers
2007
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
p73: Friend or foe in tumorigenesis
2002
Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53
2002
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data
2007
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage
2008
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1
2005
Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion.
1991
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
p53-Mediated Repression of Alpha-Fetoprotein Gene Expression by Specific DNA Binding
1999
Transcription, apoptosis and p53: catch-22
2005
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
MDMX: from bench to bedside
2007
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
p53 and Ceramide as Collaborators in the Stress Response
2013
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
Induction of cell growth regulatory genes by p53.
1996
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
Advances in targeted therapeutic agents
2010
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
1998 StandoutNobel
The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase.
1996 StandoutNobel
Cloning, primary structure and properties of a novel human integrin beta subunit.
1990
Activation and activities of the p53 tumour suppressor protein
2001
Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65
2005
Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
2009
Association of the VLA a Subunit with a Novel Protein
1989
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Death Receptors: Signaling and Modulation
1998 StandoutScience
Transcriptional control of human p53-regulated genes
2008 Standout
Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter
2002
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes.
1990
Molecular Basis of Tumor Progression: Mechanisms of Organ‐Specific Tumor Metastasis
1993
A Subset of Tumor-Derived Mutant Forms of p53 Down-Regulate p63 and p73 through a Direct Interaction with the p53 Core Domain
2001
A Novel Rb- and p300-Binding Protein Inhibits Transactivation by MyoD
2000
Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.
2000
p53 family update: p73 and p63 develop their own identities.
2001 StandoutNobel
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression.
1995
Relationship of sequence-specific transactivation and p53-regulated apoptosis in interleukin 3-dependent hematopoietic cells.
1996
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation
2012 StandoutNobel
Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M Promoters
2005
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members
2005
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Cytokines Inhibit p53-Mediated Apoptosis but Not p53-Mediated G1 Arrest
1995
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Caspases: Enemies Within
1998 StandoutScience
The IGF axis and programmed cell death
1999
Thyroid carcinoma
2003 Standout
Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells.
1990
A Matter of Life and Cell Death
1998 Science
Works of Ada Sacchi being referenced
Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization
2005
Negative Regulation of β4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression
2009
Cooperative Signaling between α6β4Integrin and ErbB-2 Receptor Is Required to Promote Phosphatidylinositol 3-Kinase-dependent Invasion
2000
Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties
2008
Physical Interaction with Human Tumor-derived p53 Mutants Inhibits p63 Activities
2002
Identification of Direct p73 Target Genes Combining DNA Microarray and Chromatin Immunoprecipitation Analyses
2002
α6β4 and α6β1 Integrins Associate with ErbB-2 in Human Carcinoma Cell Lines
1997
Stimulation of tumor cell growthin vitro by a monoclonal antibody to a tumor specific protein (TSP-180) present on the cell surface of 3LL cells
1989
Structure and Growth-Dependent Regulation of the Human Cyclin B1 Promoter
1995
Insulin‐Induced Phosphorylation of the Beta‐4 Integrin Subunit Expressed on Murine Metastatic Carcinoma Cells
1989
Mutant p53: an oncogenic transcription factor
2007
δEF1 repressor controls selectively p53 family members during differentiation
2005
The Transcriptional Coactivator Yes-Associated Protein Drives p73 Gene-Target Specificity in Response to DNA Damage
2005
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53‐mediated intrinsic‐apoptotic pathway
2009
Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity
2001
HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function
2004
Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
2006
MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts
2002
A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes
2009
NF-Y Mediates the Transcriptional Inhibition of thecyclin B1, cyclin B2, and cdc25CPromoters upon Induced G2 Arrest
2001
p53 can inhibit cell proliferation through caspase-mediated cleavage of ERK2/MAPK
2004
Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73
2000
Effects of Exogenous p53 Transduction in Thyroid Tumor Cells with Different p53 Status1
2000
Restoration of wild‐type p53 function in human cancer: Relevance for tumor therapy
2007
Induction of ErbB-3 Expression by α6β4 Integrin Contributes to Tamoxifen Resistance in ERβ1-Negative Breast Carcinomas
2008
Transcriptional regulation of hypoxia-inducible factor 1α by HIPK2 suggests a novel mechanism to restrain tumor growth
2008
Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis
2010
MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
2007
HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage
2005
Inhibition of ERα-MediatedTrans-Activation of Human Coagulation Factor XII Gene by Heteromeric Transcription Factor NF-Y
2001
MDM4 (MDMX) Overexpression Enhances Stabilization of Stress-induced p53 and Promotes Apoptosis
2004
HIPK2 inhibits both MDM2 gene and protein by, respectively, p53‐dependent and independent regulations
2005
Expression of β1, β3, β4, and β5 Integrins by Human Lung Carcinoma Cells of Different Histotypes
1994
p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells
1997
Down-regulation of cyclin B1 gene transcription in terminally differentiated skeletal muscle cells is associated with loss of functional CCAAT-binding NF-Y complex
1999
The cyclin B1 gene is actively transcribed during mitosis in HeLa cells
2001
Wild-Type p53 Induces Diverse Effects in 32D Cells Expressing Different Oncogenes
1996
Wild-type p53 modulates apoptosis of normal, IL-3 deprived, hematopoietic cells.
1995
Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells
1994
The Transcriptional Repressor ZEB Regulates p73 Expression at the Crossroad between Proliferation and Differentiation
2001
Induction of hTERT Expression and Telomerase Activity by Estrogens in Human Ovary Epithelium Cells
2000
Loss of β4 Integrin Subunit Reduces the Tumorigenicity of MCF7 Mammary Cells and Causes Apoptosis upon Hormone Deprivation
2006
Beta 4 integrin subunit expression is downregulated in low metastatic carcinoma variants.
1997
Expression of E1A in Terminally Differentiated Muscle Cells Reactivates the Cell Cycle and Suppresses Tissue-Specific Genes by Separable Mechanisms†
1996
Ligand-induced phosphorylation of a murine tumor surface protein (TSP-180) associated with metastatic phenotype.
1989
Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation
1998
The Insulin-Like Growth Factor I Receptor as a Physiologically Relevant Target of p53 in Apoptosis Caused by Interleukin-3 Withdrawal
1997
Metastatic phenotype: growth factor dependence and integrin expression.
1991
Integrin (alpha 6/beta 4) expression in human lung cancer as monitored by specific monoclonal antibodies.
1990
P53 Regulates Myogenesis by Triggering the Differentiation Activity of Prb
2000
Terminally differentiated skeletal myotubes are not confined to G0 but can enter G1 upon growth factor stimulation.
1996
Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides.
1992
Expression of tumor antigen correlated with metastatic potential of Lewis lung carcinoma and B16 melanoma clones in mice.
1986