Citation Impact
Citing Papers
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila
2006 StandoutNobel
Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone
2004
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression
2007
Sleep Drives Metabolite Clearance from the Adult Brain
2013 StandoutScience
Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
2003
The amyloid precursor protein: beyond amyloid.
2006
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
1995
The Lipoprotein Receptor LR11 Regulates Amyloid β Production and Amyloid Precursor Protein Traffic in Endosomal Compartments
2006
Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo
1997
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating Enzyme
1996
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity
1992
It all sticks together—the APP-related family of proteins and Alzheimer's disease
1999
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid β protein
2005
Thalamocortical Oscillations in the Sleeping and Aroused Brain
1993 StandoutScience
Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue
1995
Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2
2005
Maturation and Endosomal Targeting of β-Site Amyloid Precursor Protein-cleaving Enzyme
2000
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
1995
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
1995
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Polyglutamine-Expanded Human Huntingtin Transgenes Induce Degeneration of Drosophila Photoreceptor Neurons
1998
Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome
2002
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
2006 StandoutNature
Machado‐Joseph disease gene product is a cytoplasmic protein widely expressed in brain
1997
Synergistic Effects of Munc18a and X11 Proteins on Amyloid Precursor Protein Metabolism
2002
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
1998
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members
2004
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
1996
Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP
2001 Nature
Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH
1996
A huntingtin-associated protein enriched in brain with implications for pathology
1995 Nature
Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins
1995
Activation of β-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation
2003
Transgenic models of Huntington's disease
1997
Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain
1998 StandoutNobel
When more is less: Pathogenesis of glutamine repeat neurodegenerative diseases
1995
Expanded polyglutamine in the Machado–Joseph disease protein induces cell death in vitro and in vivo
1996
CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain
1995
A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor
2000
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions
1998
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Inositol trisphosphate and calcium signalling
1993 StandoutNature
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
SH3GL3 Associates with the Huntingtin Exon 1 Protein and Promotes the Formation of Polygln-Containing Protein Aggregates
1998
The X11α Protein Slows Cellular Amyloid Precursor Protein Processing and Reduces Aβ40 and Aβ42 Secretion
1998
Localization of presenilin–nicastrin complexes and γ‐secretase activity to the trans‐Golgi network
2003
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice
1997
Influenza
2018 Nobel
Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42
1999
Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
2006
Processing of β-Amyloid Precursor-like Protein-1 and -2 by γ-Secretase Regulates Transcription
2002
Selective Neuronal Degeneration in Huntington's Disease
2006
Huntingtin Immunoreactivity in the Rat Neostriatum: Differential Accumulation in Projection and Interneurons
1997
The β‐Amyloid Precursor Protein (APP) and Alzheimer's Disease: Does the Tail Wag the Dog?
2002
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway
1995
Ocular delivery of proteins and peptides: Challenges and novel formulation approaches
2018
Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation
1996
Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex
2010
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
2005
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
SV40 transformation of Swiss 3T3 cells can cause a stable reduction in the calcium requirement for growth.
1984
Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection
2010
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
The effects of brainstem peribrachial stimulation on perigeniculate neurons: The blockage of spindle waves
1989
Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families
1991
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
1996 StandoutScience
MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS
1998
An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease
1997 Nature
Inactivation of the Mouse Huntington's Disease Gene Homolog Hdh
1995 Science
Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation
1997 Standout
Intrinsic and synaptically generated delta (1–4 Hz) rhythms in dorsal lateral geniculate neurons and their modulation by light-induced fast (30–70 Hz) events
1992
A Catalytic RNA and Its Gene from Salmonella typhimurium
1985 StandoutScienceNobel
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
2022 StandoutScienceNobel
Neural Science
2000 StandoutNobel
Double-knockout mice for α- and β-synucleins: Effect on synaptic functions
2004 StandoutNobel
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Cleavage of tRNA precursors by the RNA subunit of E. coli ribonuclease P (M1 RNA) is influenced by 3′-proximal CCA in the substrates
1984 StandoutNobel
Polyglutamine pathogenesis
1999
Expression of Normal and Mutant Huntingtin in the Developing Brain
1996
The Tetrahymena ribozyme acts like an RNA restriction endonuclease
1986 StandoutNatureNobel
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
M1 RNA with large terminal deletions retains its catalytic activity
1986 StandoutNobel
Correlational Structure of Spontaneous Neuronal Activity in the Developing Lateral Geniculate Nucleus in Vivo
1999 Science
γ-Secretase Cleavage and Binding to FE65 Regulate the Nuclear Translocation of the Intracellular C-Terminal Domain (ICD) of the APP Family of Proteins
2003
An immunological determinant of RNase P protein is conserved between Escherichia coli and humans.
1989 StandoutNobel
Repeated sequences and open reading frames in the 3' flanking region of the gene for the RNA subunit of Escherichia coli ribonuclease P.
1983 StandoutNobel
Heterologous enzyme function in Escherichia coli and the selection of genes encoding the catalytic RNA subunit of RNase P.
1987 StandoutNobel
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path
1998
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
SLEEP AND AROUSAL: Thalamocortical Mechanisms
1997
Affinity chromatography with an immobilized RNA enzyme.
1986 StandoutNobel
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
1983 StandoutNobel
Mechanism by which the lectin actinohivin blocks HIV infection of target cells
2009 StandoutNobel
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the β1-adrenergic receptor
1999 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells.
2002
Glutamine repeats and inherited neurodegenerative diseases: molecular aspects
1996
Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein
2002
THE UBIQUITIN SYSTEM
1998 StandoutNobel
The thalamic reticular nucleus of the adult rat: experimental anatomical studies
1985
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
2020
Reconstitution of RNAase P activity using inactive subunits from E. coli and HeLa cells
1986 StandoutNobel
Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members
2000
Nucleotide sequence of the gene encoding the RNA subunit (M1 RNA) of ribonuclease P from Escherichia coli
1982 StandoutNobel
Works of Acy Lo being referenced
Endothelin‐1 protects astrocytes from hypoxic/ischemic injury
2001
Feedback inhibition in the cat's lateral geniculate nucleus
1994
In vivo recording of postsynaptic potentials and low threshold spikes in W cells of the cat's lateral geniculate nucleus
1990
Widespread expression of Huntington's disease gene (IT15) protein product
1995
Tropism and Innate Host Responses of the 2009 Pandemic H1N1 Influenza Virus in ex Vivo and in Vitro Cultures of Human Conjunctiva and Respiratory Tract
2010
Injectable Chemically Crosslinked Hydrogel for the Controlled Release of Bevacizumab in Vitreous: A 6-Month In Vivo Study
2015
Metabolism of the Amyloid Precursor-like Protein 2 in MDCK Cells.
1995
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).
1994
Nonlytic simian virus 40-specific 100K phosphoprotein is associated with anchorage-independent growth in simian virus 40-transformed and revertant mouse cell lines.
1981
Metabolism of the “Swedish” amyloid precursor protein variant in Madin-Darby canine kidney cells.
1994
Bacillus subtilis β-1, 4-Endoglucanase Products from Intact and Truncated Genes Are Secreted into the Extracellular Medium by Escherichia coli
1988
An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response
2012 Science
Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
1997
Trafficking of Cell-Surface β-Amyloid Precursor Protein: Evidence that a Sorting Intermediate Participates in Synaptic Vesicle Recycling
1997
Inhibition from the brain stem of inhibitory interneurones of the cat's dorsal lateral geniculate nucleus.
1984
Topography of 5.8 S rRNA in rat liver ribosomes. Identification of diethyl pyrocarbonate-reactive sites.
1982
Functional distinction of perigeniculate and thalamic reticular neurons in the cat
1982
Structure of aBacillus subtilisendo-β-l,4-glucanase gene
1986