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Citing Papers
Hereditary Anemias of the Mouse: A Review for Geneticists
1979
Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential
2009
Hallmarks of Cancer: The Next Generation
2011 Standout
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Transplantation of Normal and Leukemic Human Bone Marrow into Immune‐Deficient Mice: Development of Animal Models for Human Hematopoiesis
1991
Hemopoietic precursor cell defects in nonanemic but stem cell‐deficient W44/W44 mice
1988
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation
2008
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Bone marrow cells regenerate infarcted myocardium
2001 StandoutNature
Persistence of Leukemia-Initiating Cells in a Conditional Knockin Model of an Imatinib-Responsive Myeloproliferative Disorder
2009
Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion
2005
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
1994 StandoutNature
Cancer drug resistance: an evolving paradigm
2013 Standout
Bcr–Abl variants: biological and clinical aspects
2002
Identification and characterization of an inhibitor of haemopoietic stem cell proliferation
1990 Nature
Involvement of chemokine receptors in breast cancer metastasis
2001 StandoutNature
Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells
1998
Gene Therapy of the Immune System
1993
Role of the N-terminal Catalytic Domain of Angiotensin-converting Enzyme Investigated by Targeted Inactivation in Mice
2004 StandoutNobel
Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
1991
Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy
1996
Familial bone marrow monosomy 7. Evidence that the predisposing locus is not on the long arm of chromosome 7.
1989
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
2008
Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy
1995
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity
2010
Identification and expansion of human colon-cancer-initiating cells
2006 StandoutNature
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
Efficient tumour formation by single human melanoma cells
2008 Nature
Getting to the stem of chronic myeloid leukaemia
2008
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
1988 Standout
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
1995
Mammalian MAP kinase signalling cascades
2001 StandoutNature
Capturing and profiling adult hair follicle stem cells
2004 Standout
Stem cell origins of leukaemia and curability
1993
Growth of normal versus leukemic bone marrow cells in long term culture from acute lymphoblastic and myeloblastic leukemias
1990
Mechanisms responsible for nilotinib resistance in human chronic myeloid leukemia cells and reversal of resistance
2012
Requirement for p38α in Erythropoietin Expression
2000
Maintenance by erythropoietin of viability and maturation of murine erythroid precursor cells
1988
Identification of human brain tumour initiating cells
2004 StandoutNature
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
1997 Standout
Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells
1992
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML
2004
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
1998
Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance
1986 StandoutScienceNobel
Multilineage Potential of Adult Human Mesenchymal Stem Cells
1999 StandoutScience
Kinetic Evidence of the Regeneration of Multilineage Hematopoiesis From Primitive Cells in Normal Human Bone Marrow Transplanted Into Immunodeficient Mice
1997
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Abnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: role of malignant stromal macrophages
1995
Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
1999 StandoutScience
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors
1996 StandoutScienceNobel
Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes.
1990
Tissue Engineering
1993 StandoutScience
Single-cell transplantation determines the time when Xenopus muscle precursor cells acquire a capacity for autonomous differentiation.
1993 StandoutNobel
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
2002
Oncogenic interaction between BCR-ABL andNUP98-HOXA9 demonstrated by the use of an in vitro purging culture system
2002
Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982)
1983
Primitive Human Hematopoietic Cells Are Enriched in Cord Blood Compared With Adult Bone Marrow or Mobilized Peripheral Blood as Measured by the Quantitative In Vivo SCID-Repopulating Cell Assay
1997
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.
1996 Standout
Renal erythropoietin: Properties and production
2006
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
2006 StandoutNature
Intrinsic Human Immunodeficiency Virus Type 1 Resistance of Hematopoietic Stem Cells Despite Coreceptor Expression
1999
Isolation of a candidate human hematopoietic stem-cell population.
1992
Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene.
1996 StandoutNobel
Propagation of human blastic myeloid leukemias in the SCID mouse
1992
Neither Human Immunodeficiency Virus-1 (HIV-1) nor HIV-2 Infects Most-Primitive Human Hematopoietic Stem Cells as Assessed in Long-Term Bone Marrow Cultures
1998
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells
1994
The rate of telomere sequence loss in human leukocytes varies with age
1998 StandoutNobel
Indirect induction of differentiation in myeloid leukemic cells by lipid A
1978
Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium.
1996
Expression of Thy-1 on human hematopoietic progenitor cells.
1993
Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.
1989
Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate
2000
Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by the chicken c-myb gene
1984 StandoutNobel
Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells
1991
Polycythemia: Mechanisms and Management
1981
Requirement of Mip-1α for an Inflammatory Response to Viral Infection
1995 StandoutScienceNobel
Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin
1995
In Vitro Culture of Erythroid Colonies from Human Fetal Liver and Umbilical Cord Blood*
1979
Splenic erythroblasts in anemia‐inducing friend disease: A source of cells for studies of erythropoietin‐mediated differentiation
1984
Expansionin vitroof adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability
1997
The Basic Science of Gene Therapy
1993 Science
Gene correction in hematopoietic progenitor cells by homologous recombination
2000 StandoutNobel
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Long-term marrow culture of cells from patients with acute myelogenous leukemia. Selection in favor of normal phenotypes in some but not all cases.
1985
Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4
1999 Science
Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage
1998 StandoutNobel
Characterization and purification of a primitive hematopoietic cell type in adult mouse marrow capable of lymphomyeloid differentiation in long-term marrow "switch" cultures
1995
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
The effect of stem cell proliferation regulators demonstrated with an in vitro assay
1988
Erythropoietin: Biology and Clinical Use
1989
Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells
1990 Science
Erythropoietin
1991 Standout
Amplification of Sca-1+ Lin-WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential
1994
Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.
1990
Neural Cell Adhesion Molecule Contributes to Hemopoiesis‐Supporting Capacity of Stromal Cell Lines
2005
Retroviral transfer of the recombinant human erythropoietin receptor gene into single hematopoietic stem/progenitor cells from human cord blood increases the number of erythropoietin-dependent erythroid colonies
1996
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
1998 StandoutNobel
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
1997 StandoutScience
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Leukemia stem cells in a genetically defined murine model of blast-crisis CML
2007
Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
2003
Dynamics of chronic myeloid leukemia response to long-term targeted therapy reveal treatment effects on leukemic stem cells
2011
A mouse model for beta 0-thalassemia.
1995 StandoutNobel
Genetic control of lipopolysaccharide induced generation of serum colony stimulating factor and proliferation of splenic granulocyte/macrophage precursor cells
1976
Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia
1995
Effects of synergistic cytokine combinations, low oxygen, and irradiated stroma on the expansion of human cord blood progenitors
1992
AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells
1997
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
1996 StandoutScience
Polysialic acid governs T-cell development by regulating progenitor access to the thymus
2009 StandoutNobel
The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood
1997
Polycythemia in transgenic mice expressing the human erythropoietin gene.
1989 StandoutNobel
Dependence of highly enriched human bone marrow progenitors on hemopoietic growth factors and their response to recombinant erythropoietin.
1986
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells
1992
Characterization of a hierarchy in human acute myeloid leukemia progenitor cells
1996
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice
2002 StandoutNobel
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor
1993
Erythropoiesis in Culture
1984
Single-cell origin of mouse hemopoietic colonies expressing multiple lineages in variable combinations.
1983
Works of AC Eaves being referenced
Quantitation, Mobilization, and Clinical Use of Long-Term Culture-Initiating Cells in Blood Cell Autografts
1995
Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies
2007
Autonomous multi-lineage differentiation in vitro of primitive CD34+ cells from patients with chronic myeloid leukemia
2000
Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia
2002
Molecular analysis of clonality and bcr rearrangements in Philadelphia chromosome-positive acute lymphoblastic leukemia
1988
Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability
1989
Cytogenetic studies of early myeloid progenitor compartments in Ph1‐positive chronic myeloid leukaemia (CML) I. PERSISTENCE OF Ph1‐NEGATIVE COMMITTED PROGENITORS THAT ARE SUPPRESSED FROM DIFFERENTIATING IN VIVO
1984
Self-renewal of hemopoietic stem cells during mixed colony formation in vitro.
1981
Characterization of primitive hematopoietic cells in normal human peripheral blood
1992
Molecular analysis of clonality and bcr rearrangements in Philadelphia chromosome-positive acute lymphoblastic leukemia
1988
Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level.
1992
Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro
1989
Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis
1996
Regulated proliferation of primitive hematopoietic progenitor cells in long-term human marrow cultures
1985
Erythropoietin (Ep) dose-response curves for three classes of erythroid progenitors in normal human marrow and in patients with polycythemia vera
1978
Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer
1991
Retrovirus-mediated gene transfer to purified hemopoietic stem cells with long-term lympho-myelopoietic repopulating ability.
1989
Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer
1983
Human marrow cells capable of erythropoietic differentiation in vitro: definition of three erythroid colony responses
1977
Human marrow cells capable of erythropoietic differentiation in vitro: definition of three erythroid colony responses
1977
Erythropoietin (Ep) dose-response curves for three classes of erythroid progenitors in normal human marrow and in patients with polycythemia vera
1978
Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer
1983
IN VITRO PRODUCTION OF COLONY‐STIMULATING ACTIVITY. I. EXPOSURE OF MOUSE PERITONEAL CELLS TO ENDOTOXIN
1974
The tetrapeptide AcSDKP specifically blocks the cycling of primitive normal but not leukemic progenitors in long-term culture: evidence for an indirect mechanism
1994
Maintenance of normal and abnormal hemopoietic cell populations in long-term cultures of CML and AML marrow cells.
1985
Regulated proliferation of primitive hematopoietic progenitor cells in long-term human marrow cultures
1985
Childhood Myelodysplasia
1990
Increased erythropoietin-receptor expression on CD34-positive bone marrow cells from patients with chronic myeloid leukemia
1992
Determination of normal human serum erythropoietin levels, using mouse bone marrow.
1981
Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells.
1986
BCR-ABL expression in different subpopulations of functionally characterized Ph+ CD34+ cells from patients with chronic myeloid leukemia
1996
Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro
1989
Characterization of a primitive erythropoietic progenitor found in mouse marrow before and after several weeks in culture
1979
Three stages of erythropoietic progenitor cell differentiation distinguished by a number of physical and biologic properties
1978
A method for obtaining high quality chromosome preparations from single hemopoietic colonies on a routine basis
1981
Differentiation Stage–Specific Regulation of Primitive Human Hematopoietic Progenitor Cycling by Exogenous and Endogenous Inhibitors in an In Vivo Model
1999
High Level Engraftment of NOD/SCID Mice by Primitive Normal and Leukemic Hematopoietic Cells From Patients With Chronic Myeloid Leukemia in Chronic Phase
1998
Increased erythropoietin-receptor expression on CD34-positive bone marrow cells from patients with chronic myeloid leukemia
1992
MCP-1, not MIP-1α, Is the Endogenous Chemokine That Cooperates With TGF-β to Inhibit the Cycling of Primitive Normal but not Leukemic (CML) Progenitors in Long-Term Human Marrow Cultures
1998
Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.
1990
A quantitative bioassay for erythropoietin, using mouse bone marrow.
1981