Citation Impact
Citing Papers
Cell Death: The Significance of Apoptosis
1980 Standout
Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells
2019 StandoutNobel
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
The Immunopathology of Joint Inflammation in Rheumatoid Arthritis
1973
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes
1987
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
2000 StandoutNature
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
GcGlobulin Functions as a Cochemotaxin in the Lower Respiratory Tract: A Potential Mechanism for Lung Neutrophil Recruitment in Cigarette Smokers
1991
α1-antitrypsin deficiency
2005
Systemic inflammation in chronic obstructive pulmonary disease
2003
Smoke Extract Stimulates Lung Epithelial Cells to Release Neutrophil and Monocyte Chemotactic Activity
1998
Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung
2019
Aqueous cigarette tar extracts damage human alpha-1-proteinase inhibitor
1991
Animal models of chronic obstructive pulmonary disease
2008
Synthetic Inhibitors of Elastase
1994
Immunologic Aspects of Chronic Obstructive Pulmonary Disease
2009
Genetic Ablation of the Aryl Hydrocarbon Receptor Causes Cigarette Smoke-induced Mitochondrial Dysfunction and Apoptosis
2011
Tissue Destruction by Neutrophils
1989 Standout
Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.
1992
Oxidative Stress in Pathogenesis of Chronic Obstructive Pulmonary Disease: Cellular and Molecular Mechanisms
2005
The Hallmarks of Cancer
2000 Standout
The biochemistry of apoptosis
2000 StandoutNature
Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.
1990
Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.
1987
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
Mediators of Chronic Obstructive Pulmonary Disease
2004
Pulmonary Lipid Peroxidation in Cigarette Smokers and Lung Cancer Patients
1990
Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins
1991
Atherosclerosis — An Inflammatory Disease
1999 Standout
The Role of Oxidative Stress in the Pathogenesis??of COPD
2005
Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis.
1995
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Synovial mast cells: role in acute and chronic arthritis
2007
The Role of Oxidative Stress in Chronic Obstructive Pulmonary Disease
2004
The inflammatory reflex
2002 StandoutNature
Neutrophils and the Pathogenesis of COPD
2002
Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells.
1997
Role of oxidants/antioxidants in smoking-induced lung diseases
1996
The inhibitory effect of extracts of cigarette tar on electron transport of mitochondria and submitochondrial particles
1992
Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema
1997
Chronic obstructive pulmonary disease: molecular and cellularmechanisms
2003
Intraluminal Airway Inflammation in Chronic Bronchitis: Characterization and Correlation with Clinical Parameters
1989
Proteinase 3, a Potent Secretagogue in Airways, Is Present in Cystic Fibrosis Sputum
1999
Oxidative Stress in Chronic Obstructive Pulmonary Disease
1997 Standout
Inflammation and Repair Processes in Chronic Obstructive Pulmonary Disease
1999
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
2012 Standout
Pathologic Changes in the Peripheral Airways of Young Cigarette Smokers
1974
Selective dna‐amplification induced by carcinogens (initiators): Evidence for a role of proteases and DNA polymerase alpha
1985 StandoutNobel
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.
1991 StandoutNobel
Oxidative inactivation of leukotriene C 4 by stimulated human polymorphonuclear leukocytes
1982 StandoutNobel
Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase
1986 Nature
Tumour promoter TPA enhances transformation of human leukocytes by Epstein–Barr virus
1979 StandoutNatureNobel
Glomerular basement membrane damage in immunological glomerulonephritis.
1968
X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor.
1986 StandoutNobel
Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.
1983
Interaction of cells with immune complexes: adherence, release of constituents, and tissue injury.
1971
In vivo damage of rat lungs by oxygen metabolites.
1981
Bioregulation of lysosomal enzyme secretion from human neutrophils: roles of guanosine 3':5'-monophosphate and calcium in stimulus-secretion coupling.
1975 StandoutNobel
Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.
1987
Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase.
1982
Targeted killing of cultured cells by receptor-dependent photosensitization.
1981 StandoutNobel
Shock and Tissue Injury Induced by Recombinant Human Cachectin
1986 StandoutScienceNobel
Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl flourides
1978
Free Radicals as Mediators of Tissue Injury
1991
POLYMORPHONUCLEAR LEUKOCYTES IN IMMUNOLOGIC REACTIONS
1966
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
Proteases and oxidants in experimental pulmonary inflammatory injury.
1984
The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
1989 Standout
Clustering and endocytosis of membrane receptors can be induced in mature erythrocytes of neonatal but not adult humans.
1976 StandoutNobel
Neutrophils in Human Diseases
1987
The pulmonary ultrastructure in septic shock
1970
Gluten, major histocompatibility complex, and the small intestine
1992 Standout
The Function and Mechanism of Promoters of Carcinogenesis
1973
Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.
1980 StandoutNobel
Functional α 1 -Protease Inhibitor in the Lower Respiratory Tract of Cigarette Smokers Is Not Decreased
1983 Science
Molecular Biology of Cellular Membranes with Applications to Immunology
1974
Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity
1998
Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by the chicken c-myb gene
1984 StandoutNobel
Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.
1983 Standout
The inactivation of α-1-proteinase inhibitor by gas-phase cigarette smoke: Protection by antioxidants and reducing species
1986
Immune and inflammatory function in cigarette smokers.
1987
Insulin- and phorbol ester-stimulated phosphorylation of ribosomal protein S6.
1985
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
1997 StandoutNobel
Effects of the myeloperoxidase system on fluorescent probes of granulocyte membrane potential.
1981
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.
1981 StandoutNobel
Mechanisms of lysosomal enzyme release from human polymorphonuclear leukocytes. Effects of phorbol myristate acetate.
1975
Leukocytic proteases and the immunologic release of lysosomal enzymes.
1972
Review: Mechanisms of action of gold
1981
Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactions.
1986
Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
1979 StandoutNobel
Slow Reacting Substance of Anaphylaxis
1969
Human leukocyte granule elastase: rapid isolation and characterization
1976
Free-radical chemistry of cigarette smoke and its toxicological implications.
1985
RELEASE OF CARTILAGE MUCOPOLYSACCHARIDE-DEGRADING NEUTRAL PROTEASE FROM HUMAN LEUKOCYTES
1973 StandoutNobel
Airways Obstruction and the Risk for Lung Cancer
1987
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Oxygen Radicals and Human Disease
1987 Standout
Hormonal Control of Lysosomal Enzyme Release from Human Neutrophils: Elevation of Cyclic Nucleotide Levels by Autonomic Neurohormones
1974 StandoutNobel
Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?
1983 StandoutScienceNobel
Synthesis in E. coli of α1-antitrypsin variants of therapeutic potential for emphysema and thrombosis
1985 Nature
Irreversible bronchial goblet cell metaplasia in hamsters with elastase-induced panacinar emphysema.
1977
Studies and Perspectives of Protein Kinase C
1986 StandoutScience
Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.
1984
Leukotrienes are potent constrictors of human bronchi
1980 StandoutNatureNobel
The Neutral Proteases of Human Granulocytes
1973
Angiotensin-converting enzyme and male fertility
1998 StandoutNobel
Mitochondria and Apoptosis
1998 StandoutScience
Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
1997 StandoutNobel
Degradation of human glomerular basement membrane by stimulated neutrophils. Activation of a metalloproteinase(s) by reactive oxygen metabolites.
1987
The antioxidant action of human extracellular fluids. Effect of human serum and its protein components on the inactivation of α1-antiproteinase by hypochlorous acid and by hydrogen peroxide
1987
Changes in liver lysosome fragility, erythrocyte membrane stability, and local and systemic lysosomal enzyme levels in adjuvant-induced polyarthritis
1972 StandoutNobel
Human bronchial leucocyte proteinase inhibitor. Rapid isolation and kinetic analysis with human leucocyte proteinases
1985
Cigarette smoke impairs elastin resynthesis in lungs of hamsters with elastase-induced emphysema.
1985
Biochemistry of C3 and Related Thiolester Proteins in Infection and Inflammation
1987
Interactions of granulocytes with the lungs.
1984
Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization.
1988
Enzyme Release from Polymorphonuclear Leukocyte Lysosomes: Regulation by Autonomic Drugs and Cyclic Nucleotides
1973 StandoutScienceNobel
Isolation, characterization, and amino-terminal amino acid sequence analysis of human neutrophil cathepsin G from normal donors
1986
STUDIES ON ISOLATED MEMBRANES OF AZUROPHIL AND SPECIFIC GRANULES FROM RABBIT POLYMORPHONUCLEAR LEUKOCYTES
1972
Antiarthritic Gold Compounds Effectively Quench Electronically Excited Singlet Oxygen
1987 StandoutScienceNobel
Deficiency of vitamin E in the alveolar fluid of cigarette smokers. Influence on alveolar macrophage cytotoxicity.
1986
Hormonal Control of Neutrophil Lysosomal Enzyme Release: Effect of Epinephrine on Adenosine 3′,5′-Monophosphate
1974 StandoutScienceNobel
Secretory products of macrophages.
1987 Standout
Inactivation of human α-1-proteinase inhibitor by gas-phase cigarette smoke
1984
Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid.
1983
Mechanisms of cigarette smoke-induced COPD: insights from animal models
2008
Preservation of structural integrity of liver lysosomes and membrane-stabilizing action of anti-inflammatory drugs, catecholamines and cyclic adenosine monophosphate in isotonic salt media
1973 StandoutNobel
The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin.
1988 StandoutNobel
Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line
2001
Apoptosis in AIDS
1993 StandoutScienceNobel
Myeloperoxidase-catalyzed inactivation of alpha 1-protease inhibitor by human neutrophils.
1981
Role of Lysosomes and of Cell Membranes in Photosensitization
1966 Nature
Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitro
1971 StandoutNobel
Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.
1982
Nonphagocytic release of neutral protease and β‐glucuronidase from human neutrophils regulation by autonomic neurohormones and cyclic neucleotides
1974 StandoutNobel
Elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces
1978 StandoutNobel
Immunolocalization of elastase in human emphysematous lungs.
1986
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Mechanisms of cigarette smoke toxicity: the inactivation of human α-1-proteinase inhibitor by nitric oxide/isoprene mixtures in air
1985
Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion
1979
Breakdown of noncollagenous chondromucoprotein matrix by leukocyte lysosome granule lysates from guinea pig, rabbit, and human
1973 StandoutNobel
Works of Aaron Janoff being referenced
Elastases and Emphysema
2015
Possible Mechanisms Of Emphysema in Smokers
2015
Cigarette smoke blocks cross-linking of elastin in vitro.
1983
A rapid method for purification of human granulocyte cationic neutral proteases: purification and characterization of human granulocyte chymotrypsin-like enzyme
1975
Effects of Tobacco Smoke Components on Cellular and Biochemical Processes in the Lung
1987
Characterization of Sheep Alpha-1-Proteinase Inhibitor: Important Differences from the Human Protein
1988
An Inhibitor in Human Lung Macrophages Active Against Human Neutrophil Elastase 1
1972
Levels of Elastase Activity in Bronchoalveolar Lavage Fluids of Healthy Smokers and Nonsmokers 1– 3
1983
Characterization of the third component of complement (C3) after activation by cigarette smoke
1987
Secretion of alpha-2-macroglobulin by human alveolar macrophages
1980
Lung injury induced by leukocytic proteases.
1979
Cigarette smoke blocks cross-linking of elastin in vitro
1983
Alpha 1-proteinase inhibitor is more sensitive to inactivation by cigarette smoke than is leukocyte elastase.
1982
The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin
1976
Possible mechanisms of emphysema in smokers: cigarette smoke condensate suppresses protease inhibition in vitro.
1977
Inactivation of Bronchial Mucous Proteinase Inhibitor by Cigarette Smoke and Phagocyte-Derived Oxidants
1980
Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. II. Degradation of isolated bovine nasal cartilage proteoglycan.
1976
Vascular Injury and Lysis of Basement Membrane in vitro by Neutral Protease of Human Leukocytes
1968 Science
Effects of cigarette smoke on elastase secretion by murine macrophages.
1979
Cigarette Smoke Blocks Cross-linking of Elastin In Vitro
1983
Neutrophil Proteases in Inflammation
1972
MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES
1968
Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.
1982
Elastase-induced emphysema: retention of instilled proteinase in the rat.
1982
Neutral proteases of human polymorphonuclear leukocytes: Biochemistry, physiology, and clinical significance
1978
In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.
1979
Potential Mediator of Inflammation
1980
The course and nature of acinar cell death following pancreatic ligation in the guinea pig.
1975
Human methionine sulfoxide-peptide reductase, an enzyme capable of reactivating oxidized alpha-1-proteinase inhibitor in vitro.
1983
The role of oxidative processes in emphysema.
1983
Biochemical links between cigarette smoking and pulmonary emphysema
1983
MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES
1966
Alanine p-nitrophenyl esterase activity of human leucocyte granules
1969
The fifth component of complement (C5) is necessary for maximal pulmonary leukocytosis in mice chronically exposed to cigarette smoke
1987
Experimental emphysema induced with purified human neutrophil elastase: tissue localization of the instilled protease.
1977
The role of lysosomal elastase in the digestion of Escherichia coli proteins by human polymorphonuclear leukocytes: experiments with living leukocytes.
1976
The role of complement in cigarette smoke-induced chemotactic activity of lung fluids.
1986
Proteases, antiproteases, and oxidants: pathways of tissue injury during inflammation.
1982
Investigations into the Biochemical Mechanisms of Pulmonary Emphysema: Effects of Cigarette Smoke on Enzymes and Anti-Enzymes in the Lung
1986
Cigarette Smoke Inhalation Decreases α 1 -Antitrypsin Activity in Rat Lung
1979 Science
Inhibition of human granulocyte elastase by gold sodium thiomalate
1970
Local vascular changes induced by the cocarcinogen, phorbol myristate acetate.
1970
Inhibition of the Elastase-Like Esterase in Human Leukocyte Granules by Human Leukocyte Cell Sap
1971
Purification of human granulocyte elastase by affinity chromatography.
1973
Mediators of tissue damage in leukocyte lysosomes. X. Further studies on human granulocyte elastase.
1970
Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement.
1985
Elastase in Tissue Injury
1985
Tumorigenesis in Mouse Skin: Inhibition by Synthetic Inhibitors of Proteases
1970 Science
PATHOGENESIS OF EXPERIMENTAL SHOCK
1962
Hydrolytic activity within intact lysosomes in vitro
1968
Proteases and Lung Injury
1983
Secretion of alpha 1-proteinase inhibitor by cultured rat alveolar macrophages.
1981
Possible mechanisms of emphysema in cigarette smokers. Release of elastase from human polymorphonuclear leukocytes by cigarette smoke condensate in vitro.
1978
INACTIVATION OF ALPHA1-PROTEINASE INHIBITOR AND BRONCHIAL MUCOUS PROTEINASE INHIBITOR BY CIGARETTE SMOKE IN VITRO AND IN VIVO
1981
Elastase-Like, Esteroprotease Activity in Human and Rabbit Alveolar Macrophage Granules
1971
Depletion of Cartilage Matrix by a Neutral Protease Fraction of Human Leukocyte Lysosomes
1970
MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES
1965
Mediators of Acute Inflammation in Leucocyte Lysosomes
1967 Nature
PRODUCTION OF INFLAMMATORY CHANGES IN THE MICROCIRCULATION BY CATIONIC PROTEINS EXTRACTED FROM LYSOSOMES
1964
Further studies on an esterase inhibitor in human leukocyte cytosol.
1971
Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.
1978