Citation Impact
Citing Papers
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
2003 StandoutNobel
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
2005 StandoutNobel
MutL traps MutS at a DNA mismatch
2015 StandoutNobel
Evolution of new nonantibody proteins via iterative somatic hypermutation
2004 StandoutNobel
Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib
2013
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis
2004
MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
2005
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair
2007 StandoutNobel
BMN 673, a Novel and Highly Potent PARP1/2 Inhibitor for the Treatment of Human Cancers with DNA Repair Deficiency
2013
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
Induction of Ig Somatic Hypermutation and Class Switching in a Human Monoclonal IgM+ IgD+ B Cell Line In Vitro: Definition of the Requirements and Modalities of Hypermutation
1999
Cutting Edge: Hypermutation in Ig V Genes from Mice Deficient in the MLH1 Mismatch Repair Protein
1999
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
2011
Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern
2000
Characteristics of Sequences Around Individual Nucleotide Substitutions in IgVH Genes Suggest Different GC and AT Mutators
1999
Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA
1999
Linking class-switch recombination with somatic hypermutation
2001 StandoutNobel
Structure of the Histone Acetyltransferase Hat1
1998 StandoutNobel
Mutations occur in the Ig S region but rarely in S regions prior to class switch recombination
2003
Hypermutation in antibody affinity maturation
1999
p53: traffic cop at the crossroads of DNA repair and recombination
2005
AID and mismatch repair in antibody diversification
2002
DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
2001
BRCAness revisited
2016
PARP inhibitor combination therapy
2016
Somatic Hypermutation, Transcription, and DNA Mismatch Repair
1998
Mechanism of somatic hypermutation: Critical analysis of strand biased mutation signatures at A:T and G:C base pairs
2008
Olaparib: First Global Approval
2015
Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice
2002 StandoutNobel
Somatic insertions and deletions shape the human antibody repertoire 1 1Edited by J. Karn
1999 StandoutNobel
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation
1999
PMS2-deficiency diminishes hypermutation of a λ1 transgene in young but not older mice
1999
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
The role of p53 in tumour suppression: lessons from mouse models
1999
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Activation of Human MutS Homologs by 8-Oxo-guanine DNA Damage
2002
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
2000
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line
1998
The mismatch repair system is required for S-phase checkpoint activation
2002
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
2010 Standout
Mismatch Repair Deficiency Interferes with the Accumulation of Mutations in Chronically Stimulated B Cells and Not with the Hypermutation Process
1998
Activation-induced Cytosine Deaminase (AID) Is Actively Exported out of the Nucleus but Retained by the Induction of DNA Breaks
2004
The generation of antibody diversity through somatic hypermutation and class switch recombination
2004
Probing Immunoglobulin Gene Hypermutation with Microsatellites Suggests a Nonreplicative Short Patch DNA Synthesis Process
1998
Towards an understanding of somatic hypermutation
2001
What role for AID: mutator, or assembler of the immunoglobulin mutasome?
2003
Cancer driver mutations in protein kinase genes
2008
Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status
2010
The Coordinated Functions of the E. coli MutS and MutL Proteins in Mismatch Repair
2003
Structure and function of mismatch repair proteins
2000
Mechanisms of resistance to therapies targeting BRCA-mutant cancers
2013
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
2002 Nature
The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome
2013
Requirement of Non-canonical Activity of Uracil DNA Glycosylase for Class Switch Recombination
2006 StandoutNobel
Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting
1998
Somatic hypermutation at A·T pairs: polymerase error versus dUTP incorporation
2005
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice
2004
Synthetic lethality: the road to novel therapies for breast cancer
2016
I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation
2008
Mismatch repair and immunoglobulin gene hypermutation: did we learn something?
1999
The PU.1 and NF-EM5 binding motifs in the Igκ 3′ enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic Vκ gene
2001
Aid
2004 StandoutNobel
Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer
2012 Standout
The Mismatch Repair Protein Msh6 Influences the In Vivo AID Targeting to the Ig Locus
2006
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
2009 Standout
Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future
2012
Mammalian DNA mismatch repair protects cells from UVB-induced DNA damage by facilitating apoptosis and p53 activation
2003
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Mismatch Recognition and Uracil Excision Provide Complementary Paths to Both Ig Switching and the A/T-Focused Phase of Somatic Mutation
2004
Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets
2016
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Negative regulation of activation-induced cytidine deaminase in B cells
2006 StandoutNobel
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Mammalian DNA Mismatch Repair
1999
Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes
1999
Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase ζ
2001
Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse
2005
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
2000
A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
2001 StandoutNobel
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
2001 Nobel
The Role of Polymerase η in Somatic Hypermutation Determined by Analysis of Mutations in a Patient with Xeroderma Pigmentosum Variant
2002
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
Olaparib: an oral PARP-1 and PARP-2 inhibitor with promising activity in ovarian cancer
2015
Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
2016
Normal Somatic Hypermutation of Ig Genes in the Absence of 8-Hydroxyguanine-DNA Glycosylase
2003 StandoutNobel
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2
1998
Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice
1998
Deficiencies in Mouse Myh and Ogg1 Result in Tumor Predisposition and G to T Mutations in Codon 12 of the K-Ras Oncogene in Lung Tumors
2004 StandoutNobel
Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor
2012
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
2002 StandoutNobel
Cutting Edge: The G-U Mismatch Glycosylase Methyl-CpG Binding Domain 4 Is Dispensable for Somatic Hypermutation and Class Switch Recombination
2003
Role for Mismatch Repair Proteins Msh2, Mlh1, and Pms2 in Immunoglobulin Class Switching Shown by Sequence Analysis of Recombination Junctions
2002
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
A Hypermutable Insert in an Immunoglobulin Transgene Contains Hotspots of Somatic Mutation and Sequences Predicting Highly Stable Structures in the RNA Transcript
1998
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
The Targeting of Somatic Hypermutation Closely Resembles That of Meiotic Mutation
2001
Hijacked DNA repair proteins and unchained DNA polymerases
2008
Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
1999
Molecular Mechanisms of Antibody Somatic Hypermutation
2007
Olaparib Monotherapy in Patients With Advanced Cancer and a Germline BRCA1/2 Mutation
2014 Standout
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
Different Mismatch Repair Deficiencies All Have the Same Effects on Somatic Hypermutation
1999
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin
2003
Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination
2001 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
Somatic Hypermutation in the Absence of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-Pkcs) or Recombination-Activating Gene (Rag)1 Activity
2000
Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein.
1999
A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination
2004
Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
2003
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
2004 StandoutNobel
DNA Breaks in Hypermutating Immunoglobulin Genes: Evidence for a Break-and-Repair Pathway of Somatic Hypermutation
2001
DNA Polymerase η Contributes to Strand Bias of Mutations of A versus T in Immunoglobulin Genes
2005
Immunoglobulin Somatic Hypermutation
2007
Works of Aaron Cranston being referenced
Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1 -Mutated Mouse Mammary Tumors
2012
Tumor Growth Inhibition by Olaparib in BRCA2 Germline-Mutated Patient-Derived Ovarian Cancer Tissue Xenografts
2010
The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models
2016
Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous Brca2/p53 -Mutant Mammary Tumors In vivo and Delays Tumor Relapse in Combination with Carboplatin
2009
Signaling Mismatch Repair: The Mechanics of an Adenosine-Nucleotide Molecular Switch
2000
Female embryonic lethality in mice nullizygous for both Msh2 and p53
1997
RET Is Constitutively Activated by Novel Tandem Mutations that Alter the Active Site Resulting in Multiple Endocrine Neoplasia Type 2B
2006
Abstract A114: Preclinical evaluation of the PARP inhibitor olaparib in homologous recombination deficient (HRD) MRE11 mutant microsatellite instable (MSI) colorectal cancer
2009
Apoptosis induced by overexpression of hMSH2 or hMLH1.
1999
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
2008
Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice
1999
Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein
1998
4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1
2008