Standout Papers
- Production of a severe cystic fibrosis mutation in mice by gene targeting (1993)
- Generation and characterization of a ΔF508 cystic fibrosis mouse model (1995)
- Chloride secretion in response to guanylin in colonic epithelia from normal and transgenic cystic fibrosis mice (1994)
- Ion-transporting activity in the murine colonic epithelium of normal animals and animals with cystic fibrosis (1994)
- The genetic advantage hypothesis in cystic fibrosis heterozygotes: a murine study. (1995)
- Normalization of ion transport in murine cystic fibrosis nasal epithelium using gene transfer (1997)
- Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10‐CFTR2. (1997)
- Kinin-stimulated chloride secretion in mouse colon requires the participation of CFTR chloride channels. (1994)
- PROCEEDINGS OF THE BRITISH PHARMACOLOGICAL SOCIETY (1971)
- Restoration by intratracheal gene transfer of bicarbonate secretion in cystic fibrosis mouse gallbladder (1998)
- Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy (1993)
Citation Impact
Citing Papers
Digital image processing of intracellular pH in gastric oxyntic and chief cells
1987 StandoutNatureNobel
Angiotensin II receptors, AT1 and AT2 in the rat epididymis
1997
Pharmacological characterization of angiotensin II binding sites in the canine pancreas
1992
Long-term uncoupling of chloride secretion from intracellular calcium levels by lns(3,4,5,6)P4
1994 StandoutNatureNobel
Maintenance of functional equivalence during paralogous Hox gene evolution
2000 StandoutNatureNobel
Activation by calcium alone of chloride secretion in T84 epithelial cells
1993
Immunohistochemical localization of angiotensin II in the mouse pancreas
1998
Nasal application of the cationic liposome DC-Chol:DOPE does not alter ion transport, lung function or bacterial growth
1994
Targeting genes for self-excision in the germ line
1999 StandoutNobel
Development of synthetic membrane transporters for anions
2006
CFTR, Mucins, and Mucus Obstruction in Cystic Fibrosis
2012
CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP
1995
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans
1994 StandoutNatureNobel
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
A functional CFTR protein is required for mouse intestinal cAMP‐, cGMP‐ and Ca2+‐dependent HCO3− secretion
1997 StandoutNobel
Proceedings of the Australian Physiological and Pharmacological Society Symposium: Ion Channels EXPRESSION AND FUNCTION OF COLONIC EPITHELIAL KVLQT1 K+ CHANNELS
2001
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
2002 StandoutNatureNobel
Gene Switching and the Stability of Odorant Receptor Gene Choice
2004 StandoutNobel
Inactivation of the murine cftr gene abolishes cAMP-mediated but not Ca2+-mediated secretagogue-induced volume decrease in small-intestinal crypts
1993 StandoutNobel
Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis
1993
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
1994 StandoutNature
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera.
1997
Loss of CFTR Chloride Channels Alters Salt Absorption by Cystic Fibrosis Airway Epithelia In Vitro
1998
MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
2002 StandoutNatureNobel
A constitutively open potassium channel formed by KCNQ1 and KCNE3
2000 StandoutNature
Physiology of Local Renin-Angiotensin Systems
2006 Standout
Expression and Regulation of the Na+‐K+‐2Cl− Cotransporter NKCC1 in the Normal and CFTR‐Deficient Murine Colon
2003 StandoutNobel
Cloning and Function of the Rat Colonic Epithelial K + Channel K V LQT1
2001
A functional CFTR assay using primary cystic fibrosis intestinal organoids
2013
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Epithelial Na Channels: Function and Diversity
1992
Cross-talk between calcium and cAMP-dependent intracellular signaling pathways. Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells.
1995 StandoutNobel
Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
1993
Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues
1992
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs
1994 StandoutNatureNobel
A mouse model for the delta F508 allele of cystic fibrosis.
1995 StandoutNobel
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
1995 Standout
Uncoupling retro‐translocation and degradation in the ER‐associated degradation of a soluble protein
2004
Mice Lacking the Basolateral Na-K-2Cl Cotransporter Have Impaired Epithelial Chloride Secretion and Are Profoundly Deaf
1999
Human kidney amiloride-binding protein: cDNA structure and functional expression.
1990
Discrete changes of cell membrane capacitance observed under conditions of enhanced secretion in bovine adrenal chromaffin cells.
1982 StandoutNobel
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
Regulation of 22Na+ transport by calcium in an established kidney epithelial cell line.
1979
Role of CFTR in the Colon
2000
A new type of amiloride-sensitive cationic channel in endothelial cells of brain microvessels
1989
Axonal Ephrin-As and Odorant Receptors
2003 StandoutNobel
Amiloride: a molecular probe of sodium transport in tissues and cells
1982
Membrane Phospholipid Turnover, Receptor Function and Protein Phosphorylation
1982
Mechanisms of regulation of the Na+/H+ exchanger
1986
Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands
1997 StandoutNobel
Nedd4 mediates control of an epithelial Na + channel in salivary duct cells by cytosolic Na +
1998
Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
1996 StandoutNobel
Sodium fluxes in human fibroblasts: Effect of serum, Ca+2, and amiloride
1981
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Amiloride inhibition of the Na+-H+ exchanger in renal microvillus membrane vesicles
1981
Bacterial Biofilms: A Common Cause of Persistent Infections
1999 StandoutScience
The sodium‐transporting compartment of the epithelium of frog skin
1974
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts
1983 StandoutNatureNobel
Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease
1997 StandoutNobel
Membrane-permeant Esters of Phosphatidylinositol 3,4,5-Trisphosphate
1998 StandoutNobel
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
2000 StandoutNobel
Polarized monolayers formed by epithelial cells on a permeable and translucent support
1978 Standout
Role of Membrane Fusion in Hormonal Regulation of Epithelial Transport
1986
Stimulation of Adenosine 3′:5′-Cyclic Monophosphate Accumulation in Anterior Pituitary Gland In Vitro by Synthetic Luteinizing Hormone-Releasing Hormone
1972 StandoutNobel
The Basic Science of Gene Therapy
1993 Science
Gene correction in hematopoietic progenitor cells by homologous recombination
2000 StandoutNobel
Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: Experimental studies in animals
1996
Studies and Perspectives of Protein Kinase C
1986 StandoutScience
Genetically targeted cell disruption in Caenorhabditis elegans
1997 StandoutNobel
Pathophysiology of Gene-Targeted Mouse Models for Cystic Fibrosis
1999
SYNTHESIS, INTRACELLULAR TRANSPORT AND DISCHARGE OF EXPORTABLE PROTEINS IN THE PANCREATIC ACINAR CELL AND OTHER CELLS
1978
Science and technology for water purification in the coming decades
2008 StandoutNature
Genetic interactions affecting touch sensitivity in Caenorhabditis elegans.
1996 StandoutNobel
STIMULATION OF ANTERIOR PITUITARY ADENYL CYCLASE ACTIVITY AND ADENOSINE 3′:5′-CYCLIC PHOSPHATE BY HYPOTHALAMIC EXTRACT AND PROSTAGLANDIN E 1
1969
Regulation of intestinal Cl−and HCO 3 − secretion by uroguanylin
1998
cAMP-mediated regulation of murine intestinal/pancreatic Na+/HCO 3 − cotransporter subtype pNBC1
2003 StandoutNobel
Regulation of jejunal sodium and water absorption by angiotensin subtype receptors
1998
The amiloride-sensitive Na+/H+ exchange system in skeletal muscle cells in culture.
1982
Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung
1997
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
1990 Standout
Progress Toward Human Gene Therapy
1993
Interactions of amiloride and other blocking cations with the apical Na channel in the toad urinary bladder
1985
Multiple neuropeptide Y receptors are involved in cardiovascular regulation. Peripheral and central mechanisms
1993
Enterochromaffin-Like Cells, a Cellular Source of Uroguanylin in Rat Stomach*
1999
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
1996 StandoutScience
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 StandoutNature
A C-terminal motif found in the β 2 -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na + /H + exchanger regulatory factor family of PDZ proteins
1998 StandoutNobel
Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice.
1995 StandoutNobel
Mode of action of ANG II on ion transport in guinea pig distal colon
2000
The epithelial sodium channel. Subunit number and location of the amiloride binding site.
1987
ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor
2001 StandoutNobel
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles
1982 Nature
Na+-H+ exchange in gastric glands as measured with a cytoplasmic-trapped, fluorescent pH indicator.
1984 StandoutNobel
Carbachol-activated muscarinic (M1 and M3) receptors transfected into Chinese hamster ovary cells inhibit trafficking of endosomes.
1991 StandoutNobel
Works of A. W. Cuthbert being referenced
The effects of neuropeptide Y and its fragments upon basal and electrically stimulated ion secretion in rat jejunum mucosa
1990
Generation and characterization of a ΔF508 cystic fibrosis mouse model
1995 StandoutNobel
Ion channel formation by duramycin
1992
Cyclic AMP and Ca2+ interactions affecting epithelial chloride secretion in human cultured colonic epithelia
1993
Thapsigargin, a new calcium‐dependent epithelial anion secretagogue
1989
Production of a severe cystic fibrosis mutation in mice by gene targeting
1993 StandoutNobel
Measurement of Fluid Secretion from Intact Airway Submucosal Glands
2011
Chloride secretion in response to guanylin in colonic epithelia from normal and transgenic cystic fibrosis mice
1994 StandoutNobel
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
1993 StandoutNatureNobel
Ion-transporting activity in the murine colonic epithelium of normal animals and animals with cystic fibrosis
1994 StandoutNobel
Post-translational Disruption of the ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Molecular Chaperone Complex with Geldanamycin Stabilizes ΔF508 CFTR in the Rabbit Reticulocyte Lysate
2000
Importance of basolateral K+ conductance in maintaining Cl− secretion in murine nasal and colonic epithelia
1998
Effects of vasopressin and aldosterone on amiloride binding in toad bladder epithelial cells
1975
Neurohypophyseal hormones and sodium transport
1971
Binding of Amiloride to Sodium Channels in Frog Skin
1974
Cystic fibrosis gene update.
1994
A double (series) pump model for transporting epithelia
1972
Does intracellular sodium modify membrane permeability to sodium ions?
1977 Nature
Calcium release in relation to permeability changes in toad bladder epithelium following antidiuretic hormone
1974
The Role of Calcium Ions in the Interaction of Amiloride with Membrane Receptors
1972
Extraction of a [3H]benzamil binding component from kidney cell membranes
1981
Neuropeptide Y and Its C Terminal Fragments Attenuate Anion Secretion in Rat Jejunum Mucosaa
1990
Conversion of sodium channels to a form sensitive to cyclic AMP by component(s) from red cells
1983
Induction of transporting sites in a sodium transporting epithelium.
1976
Independent action of antidiuretic hormone, theophylline and cyclic 3′,5′‐adenosine monophosphate on cell membrane permeability in frog skin
1968
Electrogenic anion secretion in cultured rat epididymal epithelium.
1986
The effect of angiotensin II upon electrogenic ion transport in rat intestinal epithelia
1987
Uptake of [3H]benzamil at different sodium concentrations. Inferences regarding the regulation of sodium permeability.
1979
The effect of neuropeptide Y and peptide YY on electrogenic ion transport in rat intestinal epithelia.
1988
EFFECTS OF SOME PYRAZINECARBOXAMIDES ON SODIUM TRANSPORT IN FROG SKIN
1978
An upper limit to the number of sodium channels in frog skin epithelium
1973
Characteristics of the entry process for sodium in transporting epithelia as revealed with amiloride.
1976
The biochemical defect in cystic fibrosis.
1992
The genetic advantage hypothesis in cystic fibrosis heterozygotes: a murine study.
1995 StandoutNobel
Similarities between sodium channels in excitable membranes and in epithelia
1976
Importance of Guanidinium Groups for Blocking Sodium Channels in Epithelia
1976
Failure of thapsigargin to alter ion transport in human sweat gland epithelia while intracellular Ca2+ concentration is raised.
1992
Men, molecules and machines
1979
Fertilization acid production in Psammechinus eggs under pH clamp conditions, and the effects of some pyrazine derivatives*1
1978