Citation Impact
Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
2003 StandoutScienceNobel
Neutralizing antibody response during acute and chronic hepatitis C virus infection
2004 StandoutNobel
Removing T-cell epitopes with computational protein design
2014 StandoutNobel
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)
2013 StandoutNobel
Genetic immunization generates cellular and humoral immune responses against the nonstructural proteins of the hepatitis C virus in a murine model.
1998
Role of the specific T‐cell response for clearance and control of hepatitis C virus
1999
The Class I-Restricted Cytotoxic T Lymphocyte Response to Predetermined Epitopes in the Hepatitis B and C Viruses
1994
Liver‐infiltrating and circulating CD4+ T cells in chronic hepatitis C: immunodominant epitopes, HLA‐restriction and functional significance
1996
Differences between T‐cell reactivities to major myelin protein‐derived peptides in opticospinal and conventional forms of multiple sclerosis and healthy controls
2001
Possible mechanisms of action and reasons for failure of antiviral therapy in chronic hepatitis C
1999
Hepatitis C Virus–Specific CD4+T Cell Response after Liver Transplantation Occurs Early, Is Multispecific, Compartmentalizes to the Liver, and Does Not Correlate with Recurrent Disease
2001 StandoutNobel
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
2009 StandoutNature
Pathogenesis of hepatitis B virus infection
2010
Immune responses to hepatitis C and non-hepatitis C antigens in hepatitis C virus infected and HIV-1 coinfected patients
2000
Interferon‐α Treatment Induces Delayed CD4 Proliferative Responses to the Hepatitis C Virus Nonstructural Protein 3 Regardless of the Outcome of Therapy
1997
Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.
1993
Adaptive immune responses in acute and chronic hepatitis C virus infection
2005 Nature
Hepatitis C virus core region: helper T cell epitopes recognized by BALB/c and C57BL/6 mice
1995
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.
1997
Long-Term Outcome of Hepatitis C Infection after Liver Transplantation
1996
Lymphocyte Reactivity to Hepatitis C Virus (HCV) Antigens Shows Evidence for Exposure to HCV in HCV‐Seronegative Spouses of HCV‐Infected Patients
1997
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
1993 StandoutNature
Preferential loss of IL‐2–secreting CD4+ T helper cells in chronic HCV infection†
2005
Cell Mediated Immune Response to the Hepatitis C Virus
2000
Immunology of hepatitis B virus and hepatitis C virus infection
2005 Standout
Persistence of Viremia and the Importance of Long–Term Follow–Up After Acute Hepatitis C Infection
1999
Quantification of the number of cytotoxic T cells specific for an immunodominant HCV-specific CTL epitope primed by DNA immunization
2000 StandoutNobel
Expression and Immune Response to Hepatitis C Virus Core Dna-Based Vaccine Constructs
1996
Cellular and humoral immune reactions against autoantigens and hepatitis C viral antigens in chronic hepatitis C
1994
Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis
1997
Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
1995
T– and B–Cell Responses to Different Hepatitis C Virus Antigens in Patients With Chronic Hepatitis C Infection and in Healthy Anti– Hepatitis C Virus—Positive Blood Donors Without Viremi
1996
PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection
2010
The role of immune responses in the pathogenesis of hepatitis C virus infection
1997
Intrahepatic hepatitis C virus-specific cytotoxic T lymphocyte activity and response to interferon alfa therapy in chronic hepatitis C
1998
Hepatitis C: an update
2001
Immunopathogenesis of HCV Infection
1998
Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B.
1998
HLA DRB1*1501 and intrathecal inflammation in multiple sclerosis
2000
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers
2003
Protective Immune Response to Hepatitis C Virus in Chimpanzees Rechallenged Following Clearance of Primary Infection
2001 StandoutNobel
Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
2001 StandoutScience
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
1993 StandoutNature
Characterization of Liver T–Cell Receptor γδ+ T Cells Obtained From Individuals Chronically Infected With Hepatitis C Virus (Hcv): Evidence for These T Cells Playing A Role in the Liver Pathology Associated With Hcv Infections
2001 StandoutNobel
Lethal effect of the anti-Fas antibody in mice
1993 StandoutNature
Liver-Derived Hepatitis C Virus (HCV)-Specific CD4+ T Cells Recognize Multiple HCV Epitopes and Produce Interferon Gamma
2000 StandoutNobel
Determinants for Membrane Association of the Hepatitis C Virus RNA-dependent RNA Polymerase
2001 StandoutNobel
Detection of Type 2–Like T–Helper Cells in Hepatitis C Virus Infection: Implications for Hepatitis C Virus Chronicity
1997
Immune Responses to HCV and Other Hepatitis Viruses
2014
Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
2009
Adaptive Immunity to the Hepatitis C Virus
2010
Hepatitis C virus–specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C
2000
Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides
1994
Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence
1999
CD4 T Lymphocyte Proliferative Responses to Hepatitis C Virus (HCV) Antigens in Patients Coinfected with HCV and Human Immunodeficiency Virus Who Responded to Anti‐HCV Treatment
2002 StandoutNobel
Differential Cd4+ and Cd8+ T–Cell Responsiveness in Hepatitis C Virus Infection
2001
Priming of hepatitis C virus-specific cytotoxic t lymphocytes in mice following portal vein injection of a liver-specific plasmid DNA
2000 StandoutNobel
Cross‐reactivity with myelin basic protein and human herpesvirus‐6 in multiple sclerosis
2003
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
2000
Evolution of hepatitis B virus during primary infection in humans: Transient generation of cytotoxic T-cell mutants
2004
Hepatitis C virus-specific T lymphocyte responses
1995 StandoutNobel
Analysis of a Successful Immune Response against Hepatitis C Virus
1999 StandoutNobel
Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
1998
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion.
1992
The role of hepatitis C virus specific CD4+ T lymphocytes in acute and chronic hepatitis C
1996
Cancer immunotherapy comes of age
2011 StandoutNature
Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B
2003
The Fas Death Factor
1995 StandoutScience
Hepatitis C Virus‐Specific Cytolytic T Lymphocyte and T Helper Cell Responses in Seronegative Persons
1997 StandoutNobel
Suppression of Hcv–Specific T Cells Without Differential Hierarchy Demonstrated Ex Vivo In Persistent Hcv Infection
2003
Recurrence of hepatitis C virus after loss of virus-specific CD4+ T-cell response in acute hepatitis C
1999
Effect of HLA class II genotype on T helper lymphocyte responses and viral control in hepatitis C virus infection
2001
T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells
1997
Direct ex vivo analysis of hepatitis B virus-specific CD8+ T cells associated with the control of infection
1999
A genetically humanized mouse model for hepatitis C virus infection
2011 StandoutNatureNobel
HLA-DR2 Dose Effect on Susceptibility to Multiple Sclerosis and Influence on Disease Course
2003
CD4 T Helper Type 1 and Regulatory T Cells Induced against the Same Epitopes on the Core Protein in Hepatitis C Virus–Infected Persons
2002
HLA-DP: A Class II Restriction Molecule Involved in Epitope Spreading During the Development of Multiple Sclerosis
1998
T cell responses in hepatitis C: the good, the bad and the unconventional
2011
Comparative features of hepatitis C virus infection in humans and chimpanzees
1997
Induction of Interleukin‐12 Production in Chronic Hepatitis C Virus Infection Correlates with the Hepatocellular Damage
1998
Cytokine-regulated proteases in autoimmune diseases
1994
Immunopathology of hepatitis C
1997
Limited humoral immunity in hepatitis C virus infection
1999
Association of multispecific CD4+ response to hepatitis C and severity of recurrence after liver transplantation
1999 StandoutNobel
Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.
1997
Hepatitis C virus (HCV) genotype, tissue HCV antigens, hepatocellular expression of HLA-A,B,C, and intercellular adhesion-1 molecules. Clues to pathogenesis of hepatocellular damage and response to interferon treatment in patients with chronic hepatitis C.
1995
Hepatitis B Virus Biology and Pathogenesis
1992
Peptide-MHC interaction in autoimmunity
1992
Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.
1994
Genetic Immunization Generates Cellular and Humoral Immune Responses Against the Nonstructural Proteins of the Hepatitis C Virus in a Murine Model
1998
Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C
2005 StandoutNobel
Expansion of Autoreactive T Cells in Multiple Sclerosis Is Independent of Exogenous B7 Costimulation
1998
Generation of an MHC Class II-Restricted T Cell Epitope by Extracellular Processing of Hepatitis δ Antigen
1998 StandoutNobel
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates
2011 StandoutNobel
T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections
1994
Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.
1993
Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune Responses
2003
Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.
1993
Impaired Allostimulatory Capacity of Peripheral Blood Dendritic Cells Recovered from Hepatitis C Virus-Infected Individuals
1999
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease
2002
Memory T-Cell-Mediated Immune Responses Specific to an Alternative Core Protein in Hepatitis C Virus Infection
2004
Immunology and the liver
1991
Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen
2000
Rationally Engineered Therapeutic Proteins with Reduced Immunogenicity
2005
Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection
2002 Standout
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.
1995 StandoutNobel
Hepatitis C virus (HCV) specific immune responses in anti-HCV positive patients without hepatitis C viraemia
1999
Control of Heterologous Hepatitis C Virus Infection in Chimpanzees Is Associated with the Quality of Vaccine-Induced Peripheral T-Helper Immune Response
2003
IMMUNOLOGY OF MULTIPLE SCLEROSIS
2005 Standout
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers
2003
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 StandoutNobel
The Outcome of Acute Hepatitis C Predicted by the Evolution of the Viral Quasispecies
2000 Science
Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection
1997 StandoutNobel
Long-Term Follow-Up of Chimpanzees Inoculated with the First Infectious Clone for Hepatitis C Virus
1999 StandoutNobel
Contribution of Individual Amino Acids Within MHC Molecule or Antigenic Peptide to TCR Ligand Potency
2000
Viral dynamics in hepatitis B virus infection.
1996
Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection
2001
Kinetics of CD4+and CD8+Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees
2003 StandoutNobel
Cationic microparticles are a potent delivery system for a HCV DNA vaccine
2004 StandoutNobel
Sustained Dysfunction of Antiviral CD8+T Lymphocytes after Infection with Hepatitis C Virus
2001
Hepatitis C virus non-structural protein 3-specific cellular immune responses following single or combined immunization with DNA or recombinant Semliki Forest virus particles
2002
Reduction of Retrovirus-Induced Immunosuppression by In Vivo Modulation of T Cells during Acute Infection
2004 StandoutNobel
Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen.
1991
Prominent proliferative response of peripheral blood mononuclear cells to a recombinant non-structural (NS3) protein of hepatitis C virus in patients with chronic hepatitis C
1995
Cellular Immune Responses to the Hepatitis B Virus Polymerase
2004
Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis
2004
Visualization of Myelin Basic Protein (Mbp) T Cell Epitopes in Multiple Sclerosis Lesions Using a Monoclonal Antibody Specific for the Human Histocompatibility Leukocyte Antigen (Hla)-Dr2–Mbp 85–99 Complex
2000
Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires
1998
Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections
2012
Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy
1998 StandoutScience
Virus-Specific CD8+Lymphocytes Share the Same Effector-Memory Phenotype but Exhibit Functional Differences in Acute Hepatitis B and C
2002
Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees
2000
HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen.
1991
Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection
2002
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients
1997 StandoutNobel
Mapping of immunodominant CD4+ T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection
1995
Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus
2000
Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance1 1The Bundesministerium für Bildung und Forschung and the European Union, as sponsors of the study, had no role in study design, data collection, analysis, or interpretation or in the writing and the decision to submit the report for publication.
2003
Hypervariable Region 1 Variants Act as TCR Antagonists for Hepatitis C Virus-Specific CD4+ T Cells
1999
Elicitation of structure-specific antibodies by epitope scaffolds
2010 StandoutNobel
Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes
2014 StandoutNobel
Characterization of Hepatitis C Virus Core-Specific Immune Responses Primed in Rhesus Macaques by a Nonclassical ISCOM Vaccine
2001 StandoutNobel
Works of A Valli being referenced
Conserved hepatitis C virus sequences are highly immunogenic for CD4+ T cells: Implications for vaccine development
1999
Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.
1996 StandoutNobel
The preS1 antigen of hepatitis B virus is highly immunogenic at the T cell level in man.
1989
Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.
1993
Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen.
1991
Hepatitis B virus (HBV)-specific cytotoxic T-cell (CTL) response in humans: characterization of HLA class II-restricted CTLs that recognize endogenously synthesized HBV envelope antigens
1992
Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.
1990
Exogenous peptides compete for the presentation of endogenous antigens to major histocompatibility complex class II-restricted T cells.
1991
T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections
1994