Standout Papers
Citation Impact
Citing Papers
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor
2005 StandoutNobel
Beta-adrenoceptors in cardiac disease
1993
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways
2003 StandoutNobel
Use of carvedilol in chronic heart failure: Challenges in therapeutic management
1998
Genetic manipulation of myocardial ?-adrenergic receptor activation and desensitization
2004
The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure
1996 Standout
Circulating Levels of Myocardial Proteins Predict Future Deterioration of Congestive Heart Failure
2005
Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction
1992 Standout
Prognosis of congestive heart failure and predictors of mortality
1988
QT dispersion and sudden unexpected death in chronic heart failure
1994
Fixing ryanodine receptor Ca2+ leak – a novel therapeutic strategy for contractile failure in heart and skeletal muscle
2010
Measurement of plasma brain natriuretic peptide level as a guide for cardiac overload
2001
The PDZ Binding Motif of the β1 Adrenergic Receptor Modulates Receptor Trafficking and Signaling in Cardiac Myocytes
2002 StandoutNobel
β-adrenergic blockade in chronic heart failure: Principles, progress, and practice
1998
Transgenic Mice with Cardiac Overexpression of α1B-Adrenergic Receptors
1997 StandoutNobel
Molecular aspects of adrenergic signal transduction in cardiac failure
1998
GIPC Interacts with the β1-Adrenergic Receptor and Regulates β1-Adrenergic Receptor-mediated ERK Activation
2003 StandoutNobel
Update on recent clinical trials in congestive heart failure
2000
The effects of norepinephrine on myocardial biology: Implications for the therapy of heart failure
1998
Therapeutic potential of β-arrestin- and G protein-biased agonists
2010 StandoutNobel
Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor
1995 StandoutNobel
The Short-term Effects of Digoxin in Patients With Right Ventricular Dysfunction From Pulmonary Hypertension
1998
Regulation of glomerular filtration rate in chronic congestive heart failure patients
1988
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Inverse relationship between aldosterone and large artery compliance in chronically treated heart failure patients
1998
Myocardial-Directed Overexpression of the Human β1-Adrenergic Receptor in Transgenic Mice
2000
Complex heart rate variability and serum norepinephrine levels in patients with advanced heart failure
1994
Sustained augmentation of parasympathetic tone with angiotensin-converting enzyme inhibition in patients with congestive heart failure
1993
Predictors of total mortality and sudden death in mild to moderate heart failure
1989
Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms.
1992
Type 1/Type 2 Immunity in Infectious Diseases
2001
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
The Management of Chronic Heart Failure
1996
Effect of metoprolol on myocardial function and energetics in patients with nonischemic dilated cardiomyopathy: A randomized, double-blind, placebo-controlled study
1994
Identification of normal neurohormonal activity in mild congestive heart failure and stimulating effect of upright posture and diuretics
1987
Relation Between Gender, Etiology and Survival in Patients With Symptomatic Heart Failure
1996
Myocardial β-adrenergic receptor signaling in vivo: insights from transgenic mice
1996 StandoutNobel
Prognostic importance of atrial natriuretic peptide in patients with chronic heart failure
1989
Value of cardiopulmonary exercise testing and big endothelin plasma levels to predict short-term prognosis of patients with chronic heart failure
1998
Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis
1988
Control of Myocardial Contractile Function by the Level of β-Adrenergic Receptor Kinase 1 in Gene-targeted Mice
1998 StandoutNobel
Decreased spontaneous heart rate variability in congestive heart failure
1989
The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT
2004
Direct Inhibition of Type 5 Adenylyl Cyclase Prevents Myocardial Apoptosis without Functional Deterioration
2004
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)
1996
Caveolar Localization Dictates Physiologic Signaling of β2-Adrenoceptors in Neonatal Cardiac Myocytes
2002 StandoutNobel
Pathophysiologic and pharmacologic rationales for clinical management of chronic heart failure with beta-blocking agents
1993
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
1999 Standout
Spontaneous Activation of β2- but Not β1-Adrenoceptors Expressed in Cardiac Myocytes from β1β2Double Knockout Mice
2000 StandoutNobel
Beta-adrenergic receptor– G protein–adenylyl cyclase signal transduction in the failing heart
1999
Targeted Anticytokine Therapy and the Failing Heart
2005
Chronic Sympathetic Suppression in the Treatment of Chronic Congestive Heart Failure
1998
Parasympathetic withdrawal is an integral component of autonomic imbalance in congestive heart failure: Demonstration in human subjects and verification in a paced canine model of ventricular failure
1991
Myocardial Cyclic AMP and Norepinephrine Content in Human Heart Failure
1994
Effects of short- and long-term carvedilol administration on rest and exercise hemodynamic variables, exercise capacity and clinical conditions in patients with idiopathic dilated cardiomyopathy
1994
Activation of neurohumoral systems following acute myocardial infarction
1991
Predictors of prognosis in severe chronic heart failure
1992
Biomarkers in Heart Failure
2008 Standout
Protein Kinase A-mediated Phosphorylation of the β2-Adrenergic Receptor Regulates Its Coupling to Gs and Gi
2002 StandoutNobel
Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling
2000 Standout
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)
2000 Standout
Cardiac excitation–contraction coupling
2002 StandoutNature
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
2012 StandoutNobel
Decreased cardiac parasympathetic activity in chronic heart failure and its relation to left ventricular function.
1992
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
1998 StandoutNobel
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Modulation of the Ryanodine Receptor and Intracellular Calcium
2007
Development, Maturation, and Transdifferentiation of Cardiac Sympathetic Nerves
2012
Underlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy
2000 Standout
Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD).
1990 Standout
Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.
1986 Standout
Role of the renin-angiotensin system in the development of congestive heart failure in the dog as assessed by chronic converting-enzyme blockade
1984
Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction.
1994
β-Adrenergic Signaling in the Heart: Dual Coupling of the β 2 -Adrenergic Receptor to G s and G i Proteins
2001
Clinical determinants of mortality in chronic congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy
1987
Effect of the Calcium Antagonist Felodipine as Supplementary Vasodilator Therapy in Patients With Chronic Heart Failure Treated With Enalapril
1997
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
2006 StandoutNobel
Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice
2002 StandoutNobel
Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure
1986 Standout
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
2006 StandoutNobel
Changes in Brain Natriuretic Peptide and Norepinephrine Over Time and Mortality and Morbidity in the Valsartan Heart Failure Trial (Val-HeFT)
2003
Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril.
1985
The Neurohumoral Axis in Congestive Heart Failure
1984
Adrenergic effects on the biology of the adult mammalian cardiocyte.
1992
Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.
1990
Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer
1997 StandoutNobel
Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function
2003 StandoutNobel
Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure
2001 StandoutNobel
Novel markers for heart failure diagnosis and prognosis
2005
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
Carvedilol Inhibits Clinical Progression in Patients With Mild Symptoms of Heart Failure
1996
β-ADRENERGIC RECEPTORS AND RECEPTOR SIGNALING IN HEART FAILURE
1999
Heart Rate Variability
1996 Standout
Spontaneous Activation of β2- but Not β1-Adrenoceptors Expressed in Cardiac Myocytes from β1β2 Double Knockout Mice
2000 StandoutNobel
The PDZ-binding motif of the β 2 -adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes
2003 StandoutNobel
Can power spectral analysis of heart rate variability identify a high risk subgroup of congestive heart failure patients with excessive sympathetic activation? A pilot study before and after heart transplantation.
1994
Functional disorders of the sympathetic nervous system in mice lacking the α 1B subunit (Ca v 2.2) of N-type calcium channels
2001
β-Adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy
1998
Influence of β -Blockers on Mortality in Chronic Heart Failure
2000
Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction
2000 StandoutNobel
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration
2002 StandoutNobel
Works of A Simon being referenced
Plasma norepinephrine, plasma renin activity, and congestive heart failure: Relations to survival and the effects of therapy in V-HeFT II
1993
Activity of the sympathetic nervous system and renin-angiotensin system assessed by plasma hormone levels and their relation to hemodynamic abnormalities in congestive heart failure
1982
Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure
1984 Standout