Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
2012 StandoutNobel
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
2007
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
2004 StandoutScience
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130
2002 StandoutNobel
Dual-color superresolution imaging of genetically expressed probes within individual adhesion complexes
2007 StandoutNobel
Ionic events induced by epidermal growth factor. Evidence that hyperpolarization and stimulated cation influx play a role in the stimulation of cell growth.
1991
ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration
2008
Utilization of Distinct Signaling Pathways by Receptors for Vascular Endothelial Cell Growth Factor and Other Mitogens in the Induction of Endothelial Cell Proliferation
2000
Direct Stimulation of Adult Neural Stem Cells In Vitro and Neurogenesis In Vivo by Vascular Endothelial Growth Factor
2004
Angiotensin II Induces Transactivation of Two Different Populations of the Platelet-derived Growth Factor β Receptor
2000
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
1999 Standout
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
2007 StandoutNature
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
2004 Standout
Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases
2008
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades
2001 Nature
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
2006
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
1996 Standout
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Angiogenesis in cancer and other diseases
2000 StandoutNature
The Hallmarks of Cancer
2000 Standout
Regulation of tyrosine kinase activation and granule release through β-arrestin by CXCR1
2000
Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration
2000
A chemical switch for inhibitor-sensitive alleles of any protein kinase
2000 Nature
A synaptic model of memory: long-term potentiation in the hippocampus
1993 StandoutNature
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Negative regulation of cytokine signaling: STAT-induced STAT inhibitor
1999
Src Kinases Mediate STAT Growth Pathways in Squamous Cell Carcinoma of the Head and Neck
2003
CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP
1995 StandoutNobel
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
2001
Inhibition of Vascular Endothelial Growth Factor (VEGF)-induced Endothelial Cell Proliferation by a Peptide Corresponding to the Exon 7-Encoded Domain of VEGF165
1997
STATs in oncogenesis
2000 Standout
Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation
2001
A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology
2002
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism
1999
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
2006
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
2001
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
1991 StandoutNatureNobel
The Conformational Plasticity of Protein Kinases
2002
STAT signaling in the pathogenesis and treatment of leukemias
2000
Clinical applications of angiogenic growth factors and their inhibitors
1999
STAT proteins: novel molecular targets for cancer drug discovery
2000
Inositol trisphosphate and calcium signalling
1993 StandoutNature
Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2
2000
STAT proteins as novel targets for cancer therapy
1999
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The STATs of cancer — new molecular targets come of age
2004 Standout
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
2002
A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain
1998 StandoutNobel
A Critical Role for Stat3 Signaling in Immune Tolerance
2003
Dynamic Coupling between the SH2 and SH3 Domains of c-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation
2001
Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1
1999 StandoutNobel
Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase
2003 Standout
STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies
2006
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell
1997 StandoutNobel
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
2003
VEGFs, receptors and angiogenesis
1999
Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.
1998
Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains
2000
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
2004 Standout
Apical junctions and cell signalling in epithelia
1993
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Design and Synthesis of 5-Aryl-pyridone-carboxamides as Inhibitors of Anaplastic Lymphoma Kinase
2006
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.
1996 StandoutNobel
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives
1997
The Biology of Vascular Endothelial Growth Factor
1997 Standout
Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.
1991 StandoutNobel
Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate
2000
Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease
1997 StandoutNobel
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
2004
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors
1997 Science
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
2021 StandoutNobel
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.
2002
Adenylyl cyclase is dispensable for vegetative cell growth in the fission yeast Schizosaccharomyces pombe.
1990
Molecular diversity of cell-matrix adhesions
1999
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
2005 StandoutScience
Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
1996
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase
2000 StandoutScience
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
1997
Kinetic and Catalytic Mechanisms of Protein Kinases
2001
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).
2002
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.
1999
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
2001
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.
1996
Vascular endothelial growth factor (VEGF) and its receptors
1999 Standout
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Works of A Levitzki being referenced
Enhancement of chemosensitivity by tyrphostin AG825 in high-p185(neu) expressing non-small cell lung cancer cells.
1996
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
1996 Nature
Adenylyl cyclase activity of the fission yeast Schizosaccharomyces pombe is not regulated by guanyl nucleotides
1990
Crystal Structure of Hck in Complex with a Src Family–Selective Tyrosine Kinase Inhibitor
1999
Tyrphostins IV—Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines
1996
Protein Tyrosine Kinase Inhibitors as Novel Therapeutic Agents
1999
The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.
1992
Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate
1993
Tyrphostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Cell Proliferation
1989
Flk-1 as a target for tumor growth inhibition.
1996
Tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in K562 chronic myelogenous leukemia.
1994