Standout Papers
- Tinkerbell—A Tool for Interactive Segmentation of 3D Data (1997)
- SPIRE: The SPIDER Reconstruction Engine (2006)
- SPIDER and WEB: Processing and Visualization of Images in 3D Electron Microscopy and Related Fields (1996)
- A method for differentiating proteins from nucleic acids in intermediate-resolution density maps: cryo-electron microscopy defines the quaternary structure of the Escherichia coli 70S ribosome (2000)
- The parallelization of SPIDER on distributed-memory computers using MPI (2006)
- Towards high-resolution three-dimensional imaging of native mammalian tissue: Electron tomography of frozen-hydrated rat liver sections (2005)
- SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs (2008)
- Fast 3D motif search of EM density maps using a locally normalized cross-correlation function (2003)
- Direct Visualization of A-, P-, and E-Site Transfer RNAs in the Escherichia coli Ribosome (1996)
- Structure of frozen–hydrated triad junctions: A case study in motif searching inside tomograms (2008)
Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Structures of the CRISPR genome integration complex
2017 StandoutScienceNobel
The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components
2005 StandoutNobel
Arrangement of electron transport chain components in bovine mitochondrial supercomplex I 1 III 2 IV 1
2011
Reconstruction of Helical Filaments and Tubes
2010
Cotranslational Protein Folding inside the Ribosome Exit Tunnel
2015
Structures of the RNA-guided surveillance complex from a bacterial immune system
2011 StandoutNatureNobel
RELION: Implementation of a Bayesian approach to cryo-EM structure determination
2012 Standout
Elucidating the medium-resolution structure of ribosomal particles: an interplay between electron cryo-microscopy and X-ray crystallography
1999 StandoutNobel
Allosteric Communication in the Dynein Motor Domain
2014
High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy
2013 StandoutNobel
TssK Is a Trimeric Cytoplasmic Protein Interacting with Components of Both Phage-like and Membrane Anchoring Complexes of the Type VI Secretion System
2013
Negative staining and image classification — powerful tools in modern electron microscopy
2004
Identifying Conformational States of Macromolecules by Eigen-Analysis of Resampled Cryo-EM Images
2011
Structural Conservation of the Myoviridae Phage Tail Sheath Protein Fold
2011
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
A robust algorithm for the reconstruction of helical filaments using single-particle methods
2000
Mechanistic insights into the recycling machine of the SNARE complex
2015 Nature
A ratchet-like inter-subunit reorganization of the ribosome during translocation
2000 Nature
The group II intron ribonucleoprotein precursor is a large, loosely packed structure
2010 StandoutNobel
Ribosomal protein S7: a new RNA-binding motif with structural similarities to a DNA architectural factor
1997
High-resolution single-particle orientation refinement based on spectrally self-adapting common lines
2009
A 9 Å Resolution X-Ray Crystallographic Map of the Large Ribosomal Subunit
1998 StandoutNobel
Arrangement of tRNAs in Pre- and Posttranslocational Ribosomes Revealed by Electron Cryomicroscopy
1997
Solution Structure of the E. coli 70S Ribosome at 11.5 Å Resolution
2000 StandoutNobel
FREALIGN: High-resolution refinement of single particle structures
2006
Three-Dimensional Reconstruction with Contrast Transfer Function Correction from Energy-Filtered Cryoelectron Micrographs: Procedure and Application to the 70SEscherichia coliRibosome
1997 StandoutNobel
Dynamics of EF-G interaction with the ribosome explored by classification of a heterogeneous cryo-EM dataset
2004 StandoutNobel
The Polypeptide Tunnel System in the Ribosome and Its Gating in Erythromycin Resistance Mutants of L4 and L22
2001
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
2000 StandoutNatureNobel
Interactions of the Release Factor RF1 with the Ribosome as Revealed by Cryo-EM
2006 StandoutNobel
SPARX, a new environment for Cryo-EM image processing
2006
Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes
2016 Nature
EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome.
1999 StandoutNobel
Major rearrangements in the 70S ribosomal 3D structure caused by a conformational switch in 16S ribosomal RNA
1999 StandoutNobel
Structure of an RNA Silencing Complex of the CRISPR-Cas Immune System
2013
A new model for the three-dimensional folding of Escherichia coli 16 s ribosomal RNA. III † . The topography of the functional centre 1 †Paper II in this series is an accompanying paper, Mueller & Brimacombe (1997b). 1Edited by D. E. Draper
1997
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Functional conformations of the L11–ribosomal RNA complex revealed by correlative analysis of cryo-EM and molecular dynamics simulations
2006 StandoutNobel
Three-Dimensional Rearrangement of Proteins in the Tail of Bacteriophage T4 on Infection of Its Host
2004
Bsoft: Image and Molecular Processing in Electron Microscopy
2001
Structure of the Type VI Secretion System Contractile Sheath
2015 StandoutNobel
The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli
2005 StandoutNobel
Architecture of the Protein-Conducting Channel Associated with the Translating 80S Ribosome
2001 StandoutNobel
Toward an understanding of the structural basis of translation.
2003 StandoutNobel
Structural visualization of key steps in human transcription initiation
2013 Nature
Orientation of Ribosome Recycling Factor in the Ribosome from Directed Hydroxyl Radical Probing
2002
Structure and structural variations of the Escherichia coli 30 S ribosomal subunit as revealed by three-dimensional cryo-electron microscopy 1 1Edited by W. Baumeister
1999 StandoutNobel
EMAN: Semiautomated Software for High-Resolution Single-Particle Reconstructions
1999 Standout
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
2013 StandoutNatureNobel
The tail structure of bacteriophage T4 and its mechanism of contraction
2005
The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli
2011
Correlation of the expansion segments in mammalian rRNA with the fine structure of the 80 s ribosome; a cryoelectron microscopic reconstruction of the rabbit reticulocyte ribosome at 21 å resolution
1998
Classification by bootstrapping in single particle methods
2010 StandoutNobel
Conformational variability in Escherichia coli 70S ribosome as revealed by 3D cryo-electron microscopy
1999 StandoutNobel
Dynamo: A flexible, user-friendly development tool for subtomogram averaging of cryo-EM data in high-performance computing environments
2012
SIMPLE: Software for ab initio reconstruction of heterogeneous single-particles
2012
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
2014 Standout
Structural relations between collagen and mineral in bone as determined by high voltage electron microscopic tomography
1996
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
The involvement of RNA in ribosome function
2002 StandoutNatureNobel
Escherichia coli 70 S ribosome at 15 Å resolution by cryo-electron microscopy: localization of fmet-tRNAfMet and fitting of L1 protein
1998 StandoutNobel
Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation
1996
[18] Three-dimensional cryoelectron microscopy of ribosomes
2000
Image processing for electron microscopy single-particle analysis using XMIPP
2008
Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM
2004 StandoutNobel
UCSF Chimera—A visualization system for exploratory research and analysis
2004 Standout
Structures of the human and Drosophila 80S ribosome
2013 Nature
The Structure of Ribosome-Channel Complexes Engaged in Protein Translocation
2000
Complete subunit architecture of the proteasome regulatory particle
2012 Nature
FindEM—a fast, efficient program for automatic selection of particles from electron micrographs
2003
Structure of the E. coli protein-conducting channel bound to a translating ribosome
2005 StandoutNatureNobel
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Localization of the Ribosomal Protection Protein Tet(O) on the Ribosome and the Mechanism of Tetracycline Resistance
2001
Structure of the Mammalian Ribosome–Channel Complex at 17Å Resolution
2002
Effect of Buffer Conditions on the Position of tRNA on the 70 S Ribosome As Visualized by Cryoelectron Microscopy
1999 StandoutNobel
RNA Polymerase II/TFIIF Structure and Conserved Organization of the Initiation Complex
2003 StandoutNobel
A comparison of the yeast and rabbit 80 S ribosome reveals the topology of the nascent chain exit tunnel, inter-subunit bridges and mammalian rRNA expansion segments
2000
Single-particle reconstruction from EM images of helical filaments
2007
Molecular Movement inside the Translational Engine
1998
Three-dimensional Reconstruction of theEscherichia coli30 S Ribosomal Subunit in Ice
1996 StandoutNobel
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
A new model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA. I. fitting the RNA to a 3D electron microscopic map at 20 Å 1 1Edited by D. E. Drapper
1997
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
Architecture of the Ribosome–Channel Complex Derived from Native Membranes
2005
Cryo-electron Microscopic Localization of Protein L7/L12 within the Escherichia coli 70 S Ribosome by Difference Mapping and Nanogold Labeling
2001
Structural Insights into the COP9 Signalosome and Its Common Architecture with the 26S Proteasome Lid and eIF3
2010
Appion: An integrated, database-driven pipeline to facilitate EM image processing
2009
Near-Atomic Resolution for One State of F-Actin
2014
60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle
2014
Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes
2004 StandoutNobel
EMAN2: An extensible image processing suite for electron microscopy
2006 Standout
A Toolbox for ab initio 3-D reconstructions in single-particle electron microscopy
2009
Nucleotides in 23S rRNA protected by the association of 30S and 50S ribosomal subunits 1 1Edited by D. E. Draper
1999
SPRING – An image processing package for single-particle based helical reconstruction from electron cryomicrographs
2013
Direct three-dimensional localization and positive identification of RNA helices within the ribosome by means of genetic tagging and cyro-electron microscopy
1999 StandoutNobel
Matching the crystallographic structure of ribosomal protein S7 to a three-dimensional model of the 16S ribosomal RNA
1998
Crystal structure of the 30 s ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 s RNA
2002 StandoutNobel
Ab Initio Structure Determination from Electron Microscopic Images of Single Molecules Coexisting in Different Functional States
2010
DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy
2009
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM
2013 Standout
Mapping the Position of Translational Elongation Factor EF-G in the Ribosome by Directed Hydroxyl Radical Probing
1998
Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation
2004 StandoutNobel
Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM
2005
De novo protein structure determination from near-atomic-resolution cryo-EM maps
2015 StandoutNobel
Study of the Structural Dynamics of the E. coli 70S Ribosome Using Real-Space Refinement
2003 StandoutNobel
Docking structures of domains into maps from cryo-electron microscopy using local correlation
2000
Structural studies of the translational apparatus
1999 StandoutNobel
Major groove binding of the tRNA/mRNA complex to the 16 S ribosomal RNA decoding site 1 1Edited by D. E. Draper
1999
Nucleotides in 16S rRNA protected by the association of 30S and 50S ribosomal subunits 1 1Edited by D. E. Draper
1999
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
Visualization of elongation factor Tu on the Escherichia coli ribosome
1997 Nature
Estimation of variance in single-particle reconstruction using the bootstrap technique
2006 StandoutNobel
Translocation of tRNA during protein synthesis
2002
Structure of the 80S Ribosome from Saccharomyces cerevisiae—tRNA-Ribosome and Subunit-Subunit Interactions
2001 StandoutNobel
Visualization of a group II intron in the 23S rRNA of a stable ribosome
2006 StandoutNobel
The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic sec61p complex
1999
Structural organization of yeast and mammalian mediator complexes
2000 StandoutNobel
Crystal Structure of the Ribosome at 5.5 Å Resolution
2001 StandoutScience
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Visualization of protein S1 within the 30S ribosomal subunit and its interaction with messenger RNA
2001 StandoutNobel
A Conformational Switch in Escherichia coli 16 S Ribosomal RNA During Decoding of Messenger RNA
1997 Science
The Ribosome, Structure, Function, Antibiotics, and Cellular Interactions
2000
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Mineralization of Synthetic Polymer Scaffolds: A Bottom-Up Approach for the Development of Artificial Bone
2005 StandoutNobel
THE MATERIAL BONE: Structure-Mechanical Function Relations
1998 Standout
Low-resolution structure refinement in electron microscopy
2003
Conserved Structures of Mediator and RNA Polymerase II Holoenzyme
1999 StandoutScienceNobel
RIBOSOMES AND TRANSLATION
1997
Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy
2003 StandoutNobel
Transfer RNA in the hybrid P/E state: Correlating molecular dynamics simulations with cryo-EM data
2007 StandoutNobel
Single-particle selection and alignment with heavy atom cluster-antibody conjugates
1998 StandoutNobel
Subunit architecture of general transcription factor TFIIH
2012 Nobel
Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit
2001 StandoutScienceNobel
Visualization of elongation factor G on the Escherichia coli 70S ribosome: The mechanism of translocation
1998 StandoutNobel
Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins
2014
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit
2016 StandoutNobel
Cryo-EM visualization of transfer messenger RNA with two SmpBs in a stalled ribosome
2006 StandoutNobel
Initiation factors IF1 and IF2 synergistically remove peptidyl-tRNAs with short polypeptides from the P-site of translating Escherichia coli ribosomes
1998
X-ray Crystal Structures of 70 S Ribosome Functional Complexes
1999 Science
Visualization of Trna Movements on theEscherichia coli70s Ribosome during the Elongation Cycle
2000 StandoutNobel
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
2015 StandoutNobel
Location of translational initiation factor IF3 on the small ribosomal subunit
1999 StandoutNobel
Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation
2014
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Structure of the Sec23p/24p and Sec13p/31p complexes of COPII
2001 StandoutNobel
tRNA dynamics on the ribosome during translation
2004 Nobel
Structural analysis of the RSC chromatin-remodeling complex
2002 StandoutNobel
Works of A. Leith being referenced
Fast 3D motif search of EM density maps using a locally normalized cross-correlation function
2003 StandoutNobel
A method for differentiating proteins from nucleic acids in intermediate-resolution density maps: cryo-electron microscopy defines the quaternary structure of the Escherichia coli 70S ribosome
2000 StandoutNobel
Structure of frozen–hydrated triad junctions: A case study in motif searching inside tomograms
2008 StandoutNobel
Mineral and Organic Matrix Interaction in Normally Calcifying Tendon Visualized in Three Dimensions by High-Voltage Electron Microscopic Tomography and Graphic Image Reconstruction
1993
SPIDER and WEB: Processing and Visualization of Images in 3D Electron Microscopy and Related Fields
1996 Standout
SPIRE: The SPIDER Reconstruction Engine
2006 StandoutNobel
SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs
2008 StandoutNobel
Tinkerbell—A Tool for Interactive Segmentation of 3D Data
1997 StandoutNobel
Direct Visualization of A-, P-, and E-Site Transfer RNAs in the Escherichia coli Ribosome
1996 StandoutScienceNobel