Citation Impact
Citing Papers
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Tumor cell and connective tissue cell interactions in human colorectal adenocarcinoma. Transfer of platelet-derived growth factor-AB/BB to stromal cells.
1997
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.
1992
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
EXPRESSION OF PLATELET-DERIVED GROWTH FACTOR (PDGF) AND PDGF RECEPTORS IN HUMAN MALIGNANT MESOTHELIOMAIN VITRO ANDIN VIVO
1996
Distinct prion proteins in short and long scrapie incubation period mice
1987 StandoutNobel
Platelet Derived Growth Factor Expression, Myelofibrosis and Chronic Myelogenous Leukemia
1995
A Novel Monoclonal Antibody Dependent on Domain 5 of the Platelet-Derived Growth Factor Beta Receptor Inhibits Ligand Binding and Receptor Activation
1993
The PDGF family: four gene products form five dimeric isoforms
2004
Inflammation and cancer
2002 StandoutNature
Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover
1989
A community effect in animal development
1988 StandoutNatureNobel
PDGF Mediates a Neuron–Astrocyte Interaction in the Developing Retina
1996
Schwann Cells Secrete a PDGF‐like Factor: Evidence for an Autocrine Growth Mechanism involving PDGF
1990
Density‐dependent inhibitory effect of transforming growth factor‐β on human fibroblasts involves the down‐regulation of platelet‐derived growth factor α‐receptors
1993
Expression of Three Recombinant Homodimeric Isoforms of PDGF inSaccharomyces cerevisiae: Evidence for Difference in Receptor Binding and Functional Activities
1989
Role of platelet-derived growth factors in physiology and medicine
2008 Standout
An Antibody Reactive with Domain 4 of the Platelet-derived Growth Factor β Receptor Allows BB Binding while Inhibiting Proliferation by Impairing Receptor Dimerization
1997
Prions and Neurodegenerative Diseases
1987 StandoutNobel
Endogenously elicited antibodies to platelet derived growth factor‐BB and platelet cytosolic protein inhibit aortic lesion development in the cholesterol‐fed rabbit
1997
Mutation of the Prion Protein in Libyan Jews with Creutzfeldt–Jakob Disease
1991 StandoutNobel
Processing of PDGF gene products determines interactions with glycosaminoglycans
1999
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Preparation of biologically active platelet-derived growth factor type BB from a fusion protein expressed in Escherichia
1989
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
1990 StandoutNobel
β1 Integrin-mediated collagen gel contraction is stimulated by PDGF
1990
Rat Brain Capillary Endothelial Cells Express Functional PDGF B-Type Receptors
1989
A human glioma cell line secretes three structurally and functionally different dimeric forms of platelet‐derived growth factor
1988
Firefly luciferase as a tool in molecular and cell biology
1988
In vivofootprinting and functional analysis of the human c-sis/PDGF B gene promoter provides evidence for two binding sites for transcriptional activators
1995
Production of cell-associated PDGF-AA by a human sarcoma cell line: evidence for a latent autocrine effect
1996
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
1989 StandoutNatureNobel
Activated platelet‐derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line
1994
Preparation of biologically active platelet‐derived growth factor isoforms AA and AB
1990
Role of platelet‐derived growth factor in wound healing
1991
Distribution and Functions of Platelet-Derived Growth Factors and Their Receptors during Embryogenesis
1997
The conformational stability of a non‐covalent dimer of a platelet‐derived growth factor‐B mutant lacking the two cysteines involved in interchain disulfide bonds
1994
Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets
1990
Signals controlling the expression of PDGF
1996
Overexpression of PDGF-A in the Lung Epithelium of Transgenic Mice Produces a Lethal Phenotype Associated with Hyperplasia of Mesenchymal Cells
2001
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.
1988
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques
1989 StandoutNobel
Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes.
1990
Disulfide bonds in recombinant human platelet-derived growth factor BB dimer: Characterization of intermolecular and intramolecular disulfide linkages
1993
DNase‐I‐hypersensitive sites located far upstream of the human c‐sis/PDGF‐B gene comap with transcriptional enhancers and a silencer and are preceded by (part of) a new transcription unit
1993
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Large‐scale preparation of recombinant platelet‐derived growth factor AA secreted from recombinant baby hamster kidney cells
1989
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
1988 StandoutNature
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Atherosclerosis — An Inflammatory Disease
1999 Standout
Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells
2000
The Drosophila gene torso encodes a putative receptor tyrosine kinase
1989 StandoutNatureNobel
Expression of platelet-derived growth factor (PDGF)-A, PDGF-B and the PDGF-alpha receptor, but not the PDGF-beta receptor, in human malignant melanoma in vivo
1996
An S1 nuclease-sensitive region in the first intron of human platelet-derived growth factor A-chain gene contains a negatively acting cell type-specific regulatory element
1994
Autocrine growth stimulation of human meningioma cells by platelet-derived growth factor
1996
Compartmentalization of Autocrine Signal Transduction Pathways in Sis-transformed NIH 3T3 Cells
1995
Translational activation of the lck proto-oncogene
1988 StandoutNatureNobel
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
2013
Transforming Growth Factor-β Induces Platelet-Derived Growth Factor (PDGF) Messenger RNA and PDGF Secretion while Inhibiting Growth in Normal Human Mammary Epithelial Cells
1990
Involvement of growth factor receptors in the mammalian UVC response
1994
Transcriptional Regulation of the SIS/PDGF-B Gene in Human Osteosarcoma Cells by the Sp Family of Transcription Factors
1996
Swaying is a mutant allele of the proto-oncogene Wnt-1
1991 StandoutNobel
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone.
1992
PLATELET-DERIVED GROWTH FACTOR
1989
Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance.
1990
Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein
1990 StandoutNatureNobel
Dexamethasone-induced Increase in Platelet-derived Growth Factor (B) mRNA in Human Alveolar Macrophages and Myelomonocytic HL60 Macrophage-like Cells
1992
Rapid Activation of PDGF-A and -B Expression at Sites of Lung Injury in Asbestos-exposed Rats
1997
Variable Expression of Platelet-derived Growth Factor Family Proteins in Acute Lung Injury
1993
Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.
1993
Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice
1997 StandoutNobel
Localization of platelet-derived growth factor beta receptor expression in the periepithelial stroma of human breast carcinoma.
1996
Sequences of the 5′ portion of the humanc-sisgene: characterization of the transcriptional promoter and regulation of expression of the protein product by 5' untranslated mRNA sequences
1987
Growth factors: Mechanism of action and relation to oncogenes
1984
Crystal structure of human platelet-derived growth factor BB.
1992
Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule.
1992
Inducible overexpression and secretion of int-1 protein.
1989
Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF
1988 Science
Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.
1989
Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.
1993
Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-β
1989
The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.
1985 StandoutNobel
Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors
1984
In vitro mutagenesis of the v-sis transforming gene defines functional domains of its growth factor-related product.
1985
Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes
1989 Science
The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein.
1985
Effects of platelet-derived growth factor and epidermal growth factor on antigen-induced proliferation of human T-cell lines.
1985
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
1994
The nucleotide sequence and the tissue-specific expression of Drosophila c-src
1985 StandoutNobel
Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/neuOncogene
1987 StandoutScience
Spontaneous expression of the c-sis gene and release of a platelet-derived growth factorlike molecule by human alveolar macrophages.
1986
The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene
1986
Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo.
1992 StandoutNobel
Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.
1994 StandoutNobel
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.
1996
Basic fibroblast growth factor modulates the mitogenic potency of the platelet-derived growth factor (PDGF) isoforms by specific upregulation of the PDGF alpha receptor in vascular smooth muscle cells.
1992
Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface.
1988
Platelet-derived growth factor: mechanism of action and possible in vivo function.
1990
Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity
1986 Nature
Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth
1985
Secreted int-1 protein is associated with the cell surface.
1990
Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.
1985
Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain.
1991
Formation of mitogenically active PDGF-B dimer does not require interchain disulfide bonds.
1994
Green Fluorescent Protein as a Marker for Gene Expression
1994 StandoutScienceNobel
Comparison of Biological Properties and Transforming Potential of Human PDGF-A and PDGF-B Chains
1988 Science
PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage
1989
Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells.
1994
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity
1985
Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells.
1987
Platelet-derived growth factor concentrations in platelet-poor plasma and urine from patients with myeloproliferative disorders
1989
Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis
1987
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
SIS/PDGF-B promoter isolation and characterization of regulatory elements necessary for basal expression of the SIS/PDGF-B gene in U2-OS osteosarcoma cells.
1994
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.
1989
Modulation of the sis Gene Transcript During Endothelial Cell Differentiation in Vitro
1985 Science
Highly purified fibroblast-derived growth factor, an SV40-transformed fibroblast-secreted mitogen, is closely related to platelet-derived growth factor.
1985
Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus.
1998
Simian sarcoma virus transformation-specific glycopeptide: Immunological relationship to human platelet-derived growth factor
1984
Purification of melanoma growth stimulatory activity
1986
Anti-peptide antibodies detect oncogene-related proteins in urine.
1985
Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus
1985 Nature
Aberrant expression of receptors for platelet-derived growth factor in an anaplastic thyroid carcinoma cell line.
1988
Ligand-induced dimerization of the platelet-derived growth factor receptor
1989
A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains
1986 Nature
Messenger ribonucleic acid expression of platelet-derived growth factor subunits and receptors in pituitary adenomas.
1994
Autocrine growth factors and cancer
1985 Nature
Growth factors and the pathogenesis of atherosclerosis
1986
Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts
1989
Leukotrienes stimulate initiation of DNA synthesis in cultured arterial smooth muscle cells
1987
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts
1983 StandoutNatureNobel
Characterization of a tyrosine-specific kinase activity in human fibroblast membranes stimulated by platelet-derived growth factor.
1982
Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein.
1986
Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner
1988
Generation of fibrosarcomas in vivo by a retrovirus that expresses the normal B chain of platelet-derived growth factor and mimics the alternative splice pattern of the v-sis oncogene.
1989
In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins.
1988
Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation
1984
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
1989
Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor.
1985
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.
1991 StandoutNobel
Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy.
1990
Platelet-derived growth factor (PDGF) alpha receptor activation modulates the calcium mobilizing activity of the PDGF beta receptor in Balb/c3T3 fibroblasts.
1992
Interleukin-1 enhances the response of osteoblasts to platelet-derived growth factor through the alpha receptor-specific up-regulation
1991
Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer.
1989
Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cells.
1990
Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase.
1983
The Growth Factor—Platelet—Transformation Connection
1986
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation
1989
Genetics and Polymorphism of the Mouse Prion Gene Complex: Control of Scrapie Incubation Time
1988 StandoutNobel
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
1989 StandoutScience
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus
1983 Nature
Neuroblastoma cells express c-sis and produce a transforming growth factor antigenically related to the platelet-derived growth factor.
1985
Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins.
1988
Anchorage‐independent growth of primary rat embryo cells is induced by platelet‐derived growth factor and inhibited by type‐beta transforming growth factor
1986
p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.
1986
Dissociation of the chemotactic and mitogenic activities of platelet-derived growth factor by human neutrophil elastase.
1985
Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors.
1996
Autocrine Stimulation of Intracellular PDGF Receptors in v- sis -Transformed Cells
1988 Science
The Role of Alpha and Beta Platelet-Derived Growth Factor Receptor in the Vascular Response to Injury in Nonhuman Primates
1999
Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis
1985 Nature
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Growth factors in porcine full and partial thickness burn repair. Differing targets and effects of keratinocyte growth factor, platelet-derived growth factor-BB, epidermal growth factor, and neu differentiation factor.
1995
Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time.
1988 StandoutNobel
Inhibitory DNA Ligands to Platelet-Derived Growth Factor B-Chain
1996
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.
1988
Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors
1989
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines
1986 Nature
Human microvascular endothelial cells express receptors for platelet-derived growth factor.
1991
Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation.
1991
Chimeric alpha- and beta-platelet-derived growth factor (PDGF) receptors define three immunoglobulin-like domains of the alpha-PDGF receptor that determine PDGF-AA binding specificity.
1990
Phenotype modulation in primary cultures of arterial smooth muscle cells
1984
Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. Implications for the mechanism of autocrine transformation.
1988
A significant part of macrophage-derived growth factor consists of at least two forms of PDGF
1985
Tyrosine Kinase Inhibition: An Approach to Drug Development
1995 Science
Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein.
1985
[58] Purification of human platelet-derived growth factor
1985
Stable expression of human platelet-derived growth factor B chain by bovine aortic endothelial cells. Matrix association and selective proteolytic cleavage by thrombin
1994
A novel humanc-sismRNA species is transcribed from a promoter inc-sisintron 1 and contains the code for an alternative PDGF B-like protein
1995
Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer.
1988
Purification and properties of porcine platelet-derived growth factor.
1984
PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly.
1992
Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.
1991
Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens.
1989
Solution structure of murine epidermal growth factor: determination of the polypeptide backbone chain-fold by nuclear magnetic resonance and distance geometry.
1987 StandoutNobel
Platelet‐derived growth factor AA homodimer is the predominant isoform in human platelets and acute human wound fluid
1992
Nomenclature and classification of purinoceptors.
1994 Standout
Platelet-derived growth factor is an autocrine growth stimulator in retinal pigmented epithelial cells
1994
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Evidence That the v- sis Gene Product Transforms by Interaction with the Receptor for Platelet-Derived Growth Factor
1985 Science
The biology of platelet-derived growth factor
1986 Standout
Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (PDGF) receptor activation by PDGF-AB.
1991
Inhibition of platelet-derived growth factor autocrine growth stimulation by a monoclonal antibody to the human alpha platelet-derived growth factor receptor.
1993
The Pathogenesis of Atherosclerosis — An Update
1986 Standout
Human keratinocytes are a major source of cutaneous platelet-derived growth factor.
1993
The B chain of PDGF alone is sufficient for mitogenesis.
1985
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
1999 Standout
Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions
1993
Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein
1990 StandoutScienceNobel
Works of A. Johnsson being referenced
Platelet-Derived Growth Factor
1983
Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin.
1986
The phenotypic characteristics of simian sarcoma virus-transformed human fibroblasts suggest that the v-sis gene product acts solely as a PDGF receptor agonist in cell transformation.
1986
Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product.
1985
Platelet-derived growth factor: Identification of constituent polypeptide chains
1982
A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.
1988
Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor.
1986
The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.
1984
HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells
2009