Standout Papers
Citation Impact
Citing Papers
The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms.
1994 StandoutNobel
A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells
1986 Nature
Linking class-switch recombination with somatic hypermutation
2001 StandoutNobel
Excision products of immunoglobulin gene rearrangements
1989
Target Specificity of Immunoglobulin Class Switch Recombination Is Not Determined by Nucleotide Sequences of S Regions
1998
By-passing immunization
1991 StandoutNobel
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
Ku80 is required for immunoglobulin isotype switching
1998
Origins of chromosome translocations in childhood leukaemia
2003
HAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin VHlocus
1993 StandoutNobel
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function
2004 StandoutNobel
Circular DNA is excised by immunoglobulin class switch recombination
1990 StandoutNobel
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
2013 Standout
Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes
1990
The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops
1992 StandoutNobel
Structural repertoire of the human VH segments
1992 StandoutNobel
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma
1993
Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system
2014
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
1993
In-cell PCR from mRNA: amplifying and linking the rearranged immunoglobulin heavy and light chain V-genes within single cells
1992 StandoutNobel
V–J joining of immunoglobulin κ genes only occurs on one homologous chromosome
1980 Nature
Human T-cell γ genes contain N segments and have marked junctional variability
1986 Nature
Rearrangements of Immunoglobulin Genes during Differentiation and Evolution
1981 StandoutNobel
Transformation of quail embryo fibroblasts by a retrovirus carrying a normal human c-myc gene.
1986
Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε and α genes
1982 Nature
Structure of human immunoglobulin gamma genes: implications for evolution of a gene family
1982 StandoutNobel
Regulation of c-myc transcription and mRNA abundance by serum growth factors and cell contact.
1986
Somatic generation of antibody diversity.
1976 StandoutNobel
Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells.
1984
Immunochemical detection of proteins related to the human c-myc exon 1.
1986
Linkage of the four gamma subclass heavy chain genes.
1981 StandoutNobel
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
Untwisting B-Z DNA
1989
A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q
1994 StandoutNobel
Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in burkitt lymphoma
1984
Activation Of Cellular Oncogenes in Hemopoietic Cells by Chromosome Translocation
1986
Evidence for splicing of interrupted immunoglobulin variable and constant region sequences in nuclear RNA
1978 Nature
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
1984 StandoutNature
A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation
1979 Nature
The PAX3-FKHR Fusion Protein Created by the t(2;13) Translocation in Alveolar Rhabdomyosarcomas Is A More Potent Transcriptional Activator than PAX3
1995
Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin.
1983
Pax3-FKHR Knock-In Mice Show Developmental Aberrations but Do Not Develop Tumors
2002
The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus.
1988
Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.
1979
Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes
1981 StandoutNobel
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
1985 Nature
Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes
1985 Nature
Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms
1981
THE MOLECULAR GENETICS OF CELLULAR ONCOGENES
1984
Burkitt lymphoma cell line carrying a variant translocation creates new DNA at the breakpoint and violates the hierarchy of immunoglobulin gene rearrangement.
1985
The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer.
1987 StandoutNobel
T-cell gamma gene is allelically but not isotypically excluded and is not required in known functional T-cell subsets.
1987 StandoutNobel
Complete nucleotide sequence of mouse imunoglobulin μ gene and comparison with other immunoglobulin heavy chain genes
1980 StandoutNobel
The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells
1978
The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain.
1991 StandoutNobel
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.
1978
v-ras genes from harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis
1986
Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells.
1987
Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes.
1982
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression
1980 Nature
Transposition of the immunoglobulin heavy chain enhancer to the myc oncogene in a murine plasmacytoma
1985
Normal T cell development is possible without ‘functional’ gamma chain genes.
1986
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes
1981 StandoutNobel
Antibody fragments from a ‘single pot’ phage display library as immunochemical reagents.
1994 StandoutNobel
Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas.
1986
Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism.
1981 StandoutNobel
Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D
1980 Science
Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing
1978 StandoutNobel
Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene.
1985
Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains.
1982 StandoutNobel
Toward simpler and faster genome-wide mutagenesis in mice
2007 StandoutNobel
Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives.
1985
Isotype switching in murine pre-B cell lines
1983
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes
1981 StandoutNatureNobel
Isolation of variants of mouse myeloma X63 that express changed immunoglobulin class.
1980
A model for the molecular requirements of immunoglobulin heavy chain class switching
1982 Nature
Evolution of tumours and the impact of molecular oncology
1985 Nature
A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.
1984
Expression of lymphocyte surface IgE does not require switch recombination
1982 StandoutNatureNobel
Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.
1980
Antibodies of the secondary response can be expressed without switch recombination in normal mouse B cells.
1984
Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.
1980
Variation in the crossover point of kappa immunoglobulin gene V-J recombination: Evidence from a cryptic gene
1980
Cloning of mouse immunoglobulin epsilon gene and its location within the heavy chain gene cluster.
1981
5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains
1980
Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors
1985
Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin λ2b-chain gene
1980 StandoutNobel
Cmu gene rearrangement of mouse immunoglobulin genes in normal B cells occurs on both the expressed and nonexpressed chromosomes.
1981
Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor beta and lipopolysaccharide.
1992 StandoutNobel
A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.
1993
A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events
1980 Nature
Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors
1985
Regulatory elements that modulate expression of human c-myc.
1987 StandoutNobel
Ordering of mouse immunoglobulin heavy chain genes by molecular cloning
1981 StandoutNatureNobel
Deletion of Cmu genes in mouse B lymphocytes upon stimulation with LPS.
1983
<b>DELETION OF IMMUNOGLOBULIN HEAVY CHAIN GENES ACCOMPANIES THE CLASS SWITCH </b><b>REARRANGEMENT </b>
1980 StandoutNobel
Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain.
1986
Immunoglobulin gene rearrangements in normal mouse B cells.
1982
Simultaneous expression of immunoglobulin mu and delta heavy chains by a cloned B-cell lymphoma: a single copy of the VH gene is shared by two adjacent CH genes.
1982
Immunoglobulin switch region-like sequences inDrosophila melanogaster
1982 StandoutNobel
Organization of the constant-region gene family of the mouse immunoglobulin heavy chain
1982 StandoutNobel
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
1986 Standout
Multiple DNA fragment polymorphisms associated with immunoglobulin mu chain switch-like regions in man.
1983 StandoutNobel
Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome
1980 StandoutNatureNobel
A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes
1987 Nature
Simultaneous expression of mouse immunoglobulins M and D is determined by the same homolog of chromosome 12.
1980
Multiple immunoglobulin switch region homologies outside the heavy chain constant region locus
1981 Nature
THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION
1986
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Immunoglobulin Genes
1983 StandoutNobel
Antibody Diversity
1978 Science
Analysis of a T-cell tumor-specific breakpoint cluster at human chromosome 14q32.
1988
Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes
1984
Rearrangement of genetic information may produce immunoglobulin diversity
1978 Nature
The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence.
1982 StandoutNobel
Trans-acting elements modulate expression of the human c-myc gene in Burkitt lymphoma cells.
1986
Duplicated variable region genes account for double isotype expression in a human leukemic B-cell line that gives rise to single isotype-expressing cells
1991 StandoutNobel
Intervening sequences divide the gene for the constant region of mouse immunoglobulin mu chains into segments, each encoding a domain.
1980
DNA Sequences Mediating Class Switching in α-Immunoglobulins
1980 Science
Oncogene Amplification in Tumor Cells
1986
V and C parts of immunoglobulin κ-chain genes are separate in myeloma
1978 StandoutNatureNobel
Mutation of BCL-6 Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes
1998 Science
Proto-oncogene c-myc is expressed in cerebellar neurons at different developmental stages.
1986
Cloning of human immunoglobulin epsilon chain genes: evidence for multiple C epsilon genes.
1982
Cell-type-specific contacts to immunoglobulin enhancers in nuclei
1985 StandoutNatureNobel
CH gene rearrangements in IgM-bearing B cells and in the normal splenic DNA component of hybridomas making different isotypes of antibody
1980
Target sequences for cis-acting regulation within the dual promoter of the human c-myc gene.
1987
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes
1981 StandoutNatureNobel
The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.
1982
Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity
1980 Nature
Identification of a putative second T-cell receptor
1986 Nature
Somatic generation of antibody diversity
1983 StandoutNatureNobel
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing
1980 StandoutNatureNobel
A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production
1986 Nature
The arrangement and rearrangement of antibody genes
1978 Nature
Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.
1986
Somatic rearrangements forming active immunoglobulin mu genes in B and T lymphoid cell lines.
1980
The protein encoded by the human proto-oncogene c-myc.
1984 StandoutNobel
Chromosome translocations clustered 5′ of the murine c-myc gene qualitatively affect promoter usage: implications for the site of normal c-myc regulation.
1985
Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences
1981 StandoutNatureNobel
Human neoplastic B cells express more than two isotypes of immunoglobulins without deletion of heavy-chain constant-region genes.
1987 StandoutNobel
Works of A. Förster being referenced
Immunoglobulin VH‐T cell receptor Cα fusion mRNA resulting from chromosome inversion include the T cell‐associated 5′ exon ET
1992
The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development
1992
An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes
1996
Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer
2003
A rapid procedure for colony screening using nylon filters
1989
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
1993
Chromosomal Translocation Engineering to Recapitulate Primary Events of Human Cancer
2005
Inter‐chromosomal recombination of Mll and Af9 genes mediated by cre‐ loxP in mouse development
2000
Immunoglobulin VH genes are transcribed by T cells in association with a new 5' exon.
1988
The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another.
1993
Human immunoglobulin heavy chain genes: evolutionary comparisons of Cμ, Cδ and Cγ genes and associated switch sequences
1981
Immunoglobulin Genes Undergo Multiple Sequence Rearrangements during Differentiation
1981 StandoutNobel
Rearrangement of two distinct T-cell γ-chain variable-region genes in human DNA
1986 Nature
Chromatin structure of transcriptionally active and inactive human c-myc alleles.
1985
Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma.
1986
Heterogeneity of T-cell beta-chain gene rearrangements in human leukaemias and lymphomas.
1985
The T-ALL specific t(11;14)(p13;q11) translocation breakpoint cluster region is located near to the Wilms' tumour predisposition locus.
1988
Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle.
1985
Immunoglobulin‐like messenger RNA in a mouse T cell lymphoma
1977
Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma
1984 Nature
An immunoglobulin heavy-chain gene is altered in two T-cell clones
1980 Nature
The mechanism of chromosome 14 inversion in a human T cell lymphoma
1987
The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15.
1988
Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNA
1978
An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs.
1990
Truncation of exon 1 from the c-myc gene results in prolonged c-myc mRNa stability.
1985
Diversity and rearrangement of the human T cell rearranging γ genes: Nine germ-line variable genes belonging to two subgroups
1986
Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours.
1989
The role of gene deletion in the immunoglobulin heavy chain switch
1980 Nature
Transcription enhancer identified near the human Cμ immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma
1983 Nature