Citation Impact
Citing Papers
Sensitization of Human Carcinoma Cells to Alkylating Agents by Small Interfering RNA Suppression of 3-Alkyladenine-DNA Glycosylase
2005 StandoutNobel
Tumorigenesis of Chemotherapeutic Drug-Resistant Cancer Stem-Like Cells in Brain Glioma
2007
Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase
1995
Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts
2006 StandoutNobel
Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
2003
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
EGFR Antagonists in Cancer Treatment
2008 Standout
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases
2004 StandoutNobel
Phase 1 trial of temozolomide plus irinotecan plus O6‐benzylguanine in adults with recurrent malignant glioma
2009
CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis
1990 StandoutNobel
Chemotherapeutic dose intensification for treatment of malignant brain tumors: Recent developments and future directions
2002
Phase I Trial of Single-Dose Temozolomide and Continuous Administration of O6-Benzylguanine in Children with Brain Tumors: a Pediatric Brain Tumor Consortium Report
2007
Integrins in cancer: biological implications and therapeutic opportunities
2009 Standout
Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents
2000 Standout
Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O6-alkylguanine-DNA alkyltransferase
2000
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Recent progress on the Ada response for inducible repair of DNA alkylation damage
2002 StandoutNobel
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105
1995 StandoutNobel
Biodegradable polymer implants to treat brain tumors
2001
Activity of Escherichia coli DNA-glycosylases on DNA damaged by methylating and ethylating agents and influence of 3-substituted adenine derivatives
1998
MGMT: its role in cancer aetiology and cancer therapeutics
2004
A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children’s oncology group
2005 StandoutNobel
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
1992 Nature
Stimulated Emission Depletion Nanoscopy of Living Cells Using SNAP-Tag Fusion Proteins
2010 StandoutNobel
Epigenetics in Cancer
2008 Standout
Minimal Methylated Substrate and Extended Substrate Range of Escherichia coli AlkB Protein, a 1-Methyladenine-DNA Dioxygenase
2003 StandoutNobel
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
1996 StandoutNature
Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials
1997
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
2010 Standout
Malignant Gliomas in Adults
2008 Standout
Gene Silencing in Cancer in Association with Promoter Hypermethylation
2003 Standout
Quantification of O 6 -methylguanine-DNA methyltransferase mRNA in human brain tumors
1996
EFFECT OF THE ANGIOGENESIS INHIBITOR CILENGITIDE (EMD 121974) ON GLIOBLASTOMA GROWTH IN NUDE MICE
2006
Delayed repletion of O6-methylguanine—DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity
2003
How melanoma cells evade trail-induced apoptosis
2001
Current and future developments in the use of temozolomide for the treatment of brain tumours
2001
DNA repair dysregulation from cancer driver to therapeutic target
2012
Neuroblastoma
2007 Standout
Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo
2003 Standout
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
2005 Standout
The role of human O6-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli
2000
Primary brain tumours in adults
2012 Standout
Strategies for optimizing combinations of molecularly targeted anticancer agents
2006
O6-Alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications
1994
Astrocyte–endothelial interactions at the blood–brain barrier
2005 Standout
Repair of O6-alkylguanine by alkyltransferases
2000
Diagnosis and Treatment of High-Grade Astrocytoma
2007
Brain Tumors
2001 Standout
Caspase Activation Inhibits Proteasome Function during Apoptosis
2004 StandoutNobel
MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma
2005 Standout
Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2
1998 StandoutNobel
Ornithine decarboxylase inhibitors increase the cellular content of the enzyme: Implications for translational regulation
1985
Degradation of Ornithine Decarboxylase in Reticulocyte Lysate Is ATP-dependent but Ubiquitin-independent
1989 StandoutNobel
Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis
1986 StandoutScience
Polyamine metabolism and function
1982 Standout
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
2018 Standout
Androgen induction of ornithine decarboxylase mRNA in mouse kidney as studied by complementary DNA.
1984
Mismatch Repair Deficiency Does Not Mediate Clinical Resistance to Temozolomide in Malignant Glioma
2008 StandoutNobel
Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair–deficient malignant glioma xenograft
2005 StandoutNobel
Comparison of ornithine decarboxylase from rat liver, rat hepatoma and mouse kidney
1985
Ornithine decarboxylase modification and polyamine-stimulated enzyme inactivation in HTC cells
1985
Effect of 1,3-diaminopropane on ornithine decarboxylase enzyme protein in thioacetamide-treated rat liver
1983
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Phase I Trial of Temozolomide and Protracted Irinotecan in Pediatric Patients with Refractory Solid Tumors
2004
Cyclodextrin Drug Carrier Systems
1998 Standout
Modulation of cyclophosphamide activity by O ? 6 -alkylguanine-DNA alkyltransferase
1999 StandoutNobel
Phase II Trial of Temozolomide Plus O6-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma
2009
Studies of mammalian ornithine decarboxylase using a monoclonal antibody
1984
Clinical Trial Designs for Cytostatic Agents: Are New Approaches Needed?
2001
Ornithine decarboxylase in mouse kidney. Purification, characterization, and radioimmunological determination of the enzyme protein.
1983
3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity
1996
[26] Autoradiographic localization of ornithine decarboxylase
1983
A human neuroblastoma cell line with an altered ornithine decarboxylase.
1984
Effect of SBE4-β-CD, a sulfobutyl ether β-cyclodextrin, on the stability and solubility of O6-benzylguanine (NSC-637037) in aqueous solutions
1995
O6-methylguanine-DNA methyltransferase-deficient phenotype in human gliomas: frequency and time to tumor progression after alkylating agent-based chemotherapy.
1999
Prevention of Rapid Intracellular Degradation of ODC by a Carboxyl-Terminal Truncation
1989 Science
Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.
2002
Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.
2002 StandoutNobel
Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents.
1998
Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma
2006
Defective processing of methylated single-stranded DNA by E. coli alkB mutants
2000 StandoutNobel
Reversal of DNA alkylation damage by two human dioxygenases
2002 StandoutNobel
Changes in mouse kidney ornithine decarboxylase activity are brought about by changes in the amount of enzyme protein as measured by radioimmunoassay.
1983
Investigation of structure and rate of synthesis of ornithine decarboxylase protein in mouse kidney
1984
Molecular cloning and expression of the mouse ornithine decarboxylase gene.
1984
Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain
1999 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Degradation of the Proto-Oncogene Product c-Fos by the Ubiquitin Proteolytic System In Vivo and In Vitro: Identification and Characterization of the Conjugating Enzymes
1995 StandoutNobel
Phase II Trial of Carmustine Plus O6-Benzylguanine for Patients With Nitrosourea-Resistant Recurrent or Progressive Malignant Glioma
2002
Mechanism of stimulation of ornithine decarboxylase activity in transformed mouse fibroblasts
1983
THE UBIQUITIN SYSTEM
1998 StandoutNobel
The Influence of Repair Pathways on the Cytotoxicity and Mutagenicity Induced by the Pyridyloxobutylation Pathway of Tobacco-Specific Nitrosamines
2009 StandoutNobel
Androgen-regulated ornithine decarboxylase mRNAs of mouse kidney.
1984
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway
2003
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
2004 Standout
Recent advances in the biochemistry of polyamines in eukaryotes
1986 Standout
Works of A E Pegg being referenced
Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.
1998
A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.
1993
Activity of temozolomide in the treatment of central nervous system tumor xenografts.
1995
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
1991
Effect of androgens on turnover of ornithine decarboxylase in mouse kidney. Studies using labeling of the enzyme by reaction with [14C] alpha-difluoromethylornithine.
1982
Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
1996
Leukocyte O6-alkylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O6-benzylguanine.
1999
Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.
2000 Nobel
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
2001