Citation Impact
Citing Papers
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2005
Requirement of Cysteine-rich Repeats of the Fas Receptor for Binding by the Fas Ligand
1997
Using Steric Hindrance to Design New Inhibitors of Class C β-Lactamases
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Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups into the P Pocket
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Binding of cephalothin and cefotaxime to D-Ala-D-Ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum .beta.-lactamases
1995
Consensus Protein Design without Phylogenetic Bias
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1999
pKa calculations for class C ?-lactamases: The role of tyr-150
2000
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2000
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1998
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2000
Crystal Structure of Wild-type Penicillin-binding Protein 5 from Escherichia coli
2003
The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht
1999 Standout
Molecular evolution of bacterial β-lactam resistance
1996
Translation initiation: structures, mechanisms and evolution
2004
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1998
Crystallographic Structure of a Phosphonate Derivative of the Enterobacter cloacae P99 Cephalosporinase: Mechanistic Interpretation of a .beta.-Lactamase Transition-State Analog
1994
β-Lactamase of Bacillus licheniformis 749/C
1991
Apoptosis by Death Factor
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Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution
1992 Nature
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
1993 Standout
Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
1993 Nature
A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKaand binding affinity and evidence for intermolecular C–F⋯CN interactions
2004
A Weak Attractive Interaction between Organic Fluorine and an Amide Group
2004
TNF? and the TNF receptor superfamily: Structure-function relationship(s)
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The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2
1999
Structural Bases of Stability–function Tradeoffs in Enzymes
2002
CAR1, a TNFR–Related Protein, Is a Cellular Receptor for Cytopathic Avian Leukosis–Sarcoma Viruses and Mediates Apoptosis
1996
The Crystal Structure of a Penicilloyl-serine Transferase of Intermediate Penicillin Sensitivity
1999
Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone
1997
β‐lactamase TEM1 of E. coli Crystal structure determination at 2.5 Å resolution
1992
Evolution of a designed protein assembly encapsulating its own RNA genome
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A Structure-Based Analysis of the Inhibition of Class A .beta.-Lactamases by Sulbactam
1994
Contenders in FasL/TNF death signaling
1995
Effects on Substrate Profile by Mutational Substitutions at Positions 164 and 179 of the Class A TEMpUC19 β-Lactamase from Escherichia coli
1999
Transmembrane Signaling by Receptor Oligomerization
2003
Dimerization of cell surface receptors in signal transduction
1995
The coming of age of de novo protein design
2016 StandoutNatureNobel
Design of biologically active binary protein 2D materials
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Structural basis for self-association and receptor recognition of human TRAF2
1999 Nature
Searching protein structure databases has come of age
1994
Electrostatic analysis of TEM1 β-lactamase: effect of substrate binding, steep potential gradients and consequences of site-directed mutations
1995
Molecular Evolution of a Class C β-Lactamase Extending Its Substrate Specificity
1995
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
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T cell life and death signalling via TNF-receptor family members
2000
STRUCTURE OF WHEAT SERINE CARBOXYPEPTIDASE /II$ AT 3.5-*ANGSTROMS RESOLUTION. A NEW CLASS OF SERINE PROTEINASE
1991
Crystal Structure of Active Site-Inhibited Human Coagulation Factor VIIa (des-Gla)
1999
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase
2001
TROY, a Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily, Exhibits a Homology with Edar and Is Expressed in Embryonic Skin and Hair Follicles
2000
Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum
1991 Nature
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HCαCO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles
2004
The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
1994 Standout
Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides
1991
The Role of Tyrosine 150 in Catalysis of .beta.-Lactam Hydrolysis by AmpC .beta.-Lactamase from Escherichia coli Investigated by Site-Directed Mutagenesis
1994
A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on pKa and log D Values
2006
TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex
1996
Crystallographic Evidence for Dimerization of Unliganded Tumor Necrosis Factor Receptor
1995
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
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The Polar Hydrophobicity of Fluorinated Compounds
2004
Revealing the world of RNA interference
2004 StandoutNatureNobel
Two tumour necrosis factor receptors: structure and function
1995
Generating functional protein variants with variational autoencoders
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Insights into Class D β-Lactamases Are Revealed by the Crystal Structure of the OXA10 Enzyme from Pseudomonas aeruginosa
2000
Fluorine in Medicinal Chemistry
2004 Standout
Hydrolysis of Third-generation Cephalosporins by Class C β-Lactamases
2004
Crystal Structures of the Apo and Penicillin-acylated Forms of the BlaR1 β-Lactam Sensor of Staphylococcus aureus
2004
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Structure-Based Discovery of a Novel, Noncovalent Inhibitor of AmpC β-Lactamase
2002
Crystal structure of a hepatitis delta virus ribozyme
1998 StandoutNatureNobel
The TNF and TNF Receptor Superfamilies
2001 Standout
Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
1995
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Site-directed Mutagenesis of Glutamate 166 in Two β-Lactamases
1997
TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways
1996 Standout
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Functional Organization of the Nuclear Envelope
1988
mScarlet: a bright monomeric red fluorescent protein for cellular imaging
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Inferences, questions and possibilities in Toll-like receptor signalling
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Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
A general module for RNA crystallization
1998 StandoutNobel
TNFRSF1A mutations and autoinflammatory syndromes
2000
De novo protein design by deep network hallucination
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The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Accurate design of megadalton-scale two-component icosahedral protein complexes
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Mechanism of acyl transfer by the class A serine β-lactamase of Streptomyces albus G
1991
Identification and Characterization of a Shared TNFR-Related Receptor for Subgroup B, D, and E Avian Leukosis Viruses Reveal Cysteine Residues Required Specifically for Subgroup E Viral Entry
2000
A monoclonal antibody against nuclear lamina proteins reveals cell type-specificity in Xenopus laevis
1984
Signaling by the TNF Receptor Superfamily and T Cell Homeostasis
2000
Crystal structure of haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes.
1991
cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.
1986 StandoutNobel
Identification of a major polypeptide of the nuclear pore complex.
1982
Characterization of OXA-25, OXA-26, and OXA-27, Molecular Class D β-Lactamases Associated with Carbapenem Resistance in Clinical Isolates of Acinetobacter baumannii
2001
Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions.
1994
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Identification of Two GTP-Binding Proteins in the Chloroplast Protein Import Machinery
1994 StandoutScienceNobel
Unexpected crucial role of residue 225 in serine proteases
1999
Structure of wheat serine carboxypeptidase II at 3.5-A resolution. A new class of serine proteinase.
1990
Identification, developmental regulation, and response to heat shock of two antigenically related forms of a major nuclear envelope protein in Drosophila embryos: application of an improved method for affinity purification of antibodies using polypeptides immobilized on nitrocellulose blots
1984
β -Lactamases: which ones are clinically important?
2000
Evidence for a Functional Role of the Dynamics of Glycine-121 ofEscherichia coliDihydrofolate Reductase Obtained from Kinetic Analysis of a Site-Directed Mutant
1997
Consensus-derived structural determinants of the ankyrin repeat motif
2002
The structure of aspartyl dipeptidase reveals a unique fold with a Ser-His-Glu catalytic triad
2000
Crystallographic analysis of CD40 recognition and signaling by human TRAF2
1999
Structural and Functional Aspects of Metal Sites in Biology
1996 Standout
Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein
1991 StandoutScience
Mixed Quantum Mechanical/Molecular Mechanical (QM/MM) Study of the Deacylation Reaction in a Penicillin Binding Protein (PBP) versus in a Class C β-Lactamase
2004
Identification and characterization of a nuclear pore complex protein
1986 StandoutNobel
pKa measurements from nuclear magnetic resonance of tyrosine-150 in class C beta-lactamase
2003
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
1995 Standout
Comparative Analysis of Haemostatic Proteinases: Structural Aspects of Thrombin, Factor Xa, Factor IXa and Protein C
1997
Karyoskeletal proteins and the organization of the amphibian oocyte nucleus
1984
Bacterial Resistance to β-Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity
2005 Standout
Interfacial Catalysis: the Mechanism of Phospholipase A 2
1990 StandoutScience
Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry
2005 Standout
Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors: Crystallographic Structures Show Unexpected Binding of 1,4-Thiazepine Intermediates
2004
Functional evolution of the serine β-lactamase active site
2002
Immunological analysis of nuclear lamina proteins
1980
Nuclear reconstitution in vitro: Stages of assembly around protein-free DNA
1987
A monoclonal antibody which recognises each of the nuclear lamin polypeptides in mammalian cells.
1983
Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells
1997
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
A Hot Spot of Binding Energy in a Hormone-Receptor Interface
1995 StandoutScience
Mechanisms of Antibiotic Resistance: QM/MM Modeling of the Acylation Reaction of a Class A β-Lactamase with Benzylpenicillin
2005
Immunological localization of the major architectural protein associated with the nuclear envelope of the Xenopus laevis oocyte
1982
Anionic subsites of the acetylcholinesterase from Torpedo californica: affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl-aziridinium.
1990
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Structure-Based Approach for Binding Site Identification on AmpC β-Lactamase
2002
The nuclear envelope lamina is reversibly depolymerized during mitosis
1980 StandoutNobel
Chimeric tumor necrosis factor receptors with constitutive signaling activity.
1995 StandoutNobel
Aggregation of the intracellular domain of the type 1 tumor necrosis factor receptor defined by the two-hybrid system.
1994
Organization and modulation of nuclear lamina structure
1984
Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies
1997
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Kinship and Diversification of Bacterial Penicillin-Binding Proteins and β-Lactamases
1998
MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
1999
Nuclear ribonucleoprotein release and nucleoside triphosphatase activity are inhibited by antibodies directed against one nuclear matrix glycoprotein.
1983
Nuances of Mechanisms and Their Implications for Evolution of the Versatile β-Lactamase Activity: From Biosynthetic Enzymes to Drug Resistance Factors
1997
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Gene gating: a hypothesis.
1985
New enzyme lineages by subdomain shuffling
1998 Nobel
Identification of Amino Acid Residues Important for Ligand Binding to Fas
1997
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
More of the catalytic triad
1990 Nature
The nuclear lamins
1986
Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.
1994 StandoutNobel
Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase.
1993
Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors
2006
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Standard Numbering Scheme for Class B β-Lactamases
2001
Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
1990 StandoutNobel
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
Crystal Structures of Substrate and Inhibitor Complexes with AmpC β-Lactamase: Possible Implications for Substrate-Assisted Catalysis
2000
Works of A. D’Arcy being referenced
From DNA sequence to improved functionality: using protein sequence comparisons to rapidly design a thermostable consensus phytase
2000
Crystallization and Preliminary Crystallographic Analysis of a TNF-β-55 kDa TNF Receptor Complex
1993
A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF⋅⋅⋅CO Interactions
2003
Structure of human pancreatic lipase
1990 Nature
High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[({2-[(5-iodopyridin-2-yl)amino]-ethyl}amino)-acetyl]-2-cyano-(S)-pyrrolidine
2003
Crystal structure of human dihydrofolate reductase complexed with folate
1988
Microseed matrix screening for optimization in protein crystallization: what have we learned?
2014
Crystal Structures of Streptococcus pneumoniaeN-Acetylglucosamine-1-phosphate Uridyltransferase, GlmU, in Apo Form at 2.33Å Resolution and in Complex with UDP-N-Acetylglucosamine and Mg2+ at 1.96Å Resolution
2001
Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation
1993
Mapping the active site ofEscherichia colimalonyl-CoA–acyl carrier protein transacylase (FabD) by protein crystallography
2006
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors
2004
Refined crystal structure of β-lactamase from Citrobacter freundiiindicates a mechanism for β-lactam hydrolysis
1990 Nature
Renin inhibition by substituted piperidines: A novel paradigm for the inhibition of monomeric aspartic proteinases?
1999
Crystallizing proteins – a rational approach?
1994
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
1996 Nature
Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor
1994
Crystal structure of human platelet-derived growth factor BB.
1992
Light scattering of proteins as a criterion for crystallization
1992
A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF⋅⋅⋅CO Interactions
2003
Localization of a nuclear envelope-associated protein by indirect immunofluorescence microscopy using antibodies against a major polypeptide from rat liver fractions enriched in nuclear envelope-associated material.
1978
Interaction of antibodies against nuclear envelope-associated proteins from rat liver nuclei with rodent and human cells
1978