Citation Impact
Citing Papers
Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response
2015
DNA-Encoded Chemical Libraries: A Selection System Based on Endowing Organic Compounds with Amplifiable Information
2018
Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors
2017
Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation
2020
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment
2018 StandoutNobel
Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype
2016 StandoutNobel
Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation**
2021 StandoutNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
2016
Inference and analysis of cell-cell communication using CellChat
2021 Standout
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Bardoxolone conjugation enables targeted protein degradation of BRD4
2020
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
2015
Myeloid-derived suppressor cells coming of age
2018 Standout
Inflammation and Cancer: Triggers, Mechanisms, and Consequences
2019 Standout
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019 Standout
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment
2017 StandoutNobel
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
2021 Standout
Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1
2019
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
2021 Standout
Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
2014
Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells
2017
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway
2015
RAS-targeted therapies: is the undruggable drugged?
2020
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
2021 StandoutNobel
Medulloblastomics revisited: biological and clinical insights from thousands of patients
2019
Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes
2022
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Targeted protein degradation: current and future challenges
2020
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Immunoregulation by members of the TGFβ superfamily
2016
Targeted protein degradation: expanding the toolbox
2019
Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma
2020
The Keap1–Nrf2 protein–protein interaction: A suitable target for small molecules
2017
Oxidative Stress in Cancer
2020 Standout
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
2022 Standout
Targeting ferroptosis as a vulnerability in cancer
2022 Standout
Homing in: Mechanisms of Substrate Targeting by Protein Kinases
2018
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
Kinase inhibitors: the road ahead
2018
Discovering protein−ligand chalcogen bonding in the protein data bank using endocyclic sulfur-containing heterocycles as ligand search subsets
2017
Cancer-related inflammation and treatment effectiveness
2014 Standout
Structural Basis for Receptor-Mediated Selective Autophagy of Aminopeptidase I Aggregates
2016 StandoutNobel
Signaling Receptors for TGF-β Family Members
2016
Nrf2 activation improves experimental rheumatoid arthritis
2023 StandoutNobel
Inhibition of the NRF2/KEAP1 Axis: A Promising Therapeutic Strategy to Alter Redox Balance of Cancer Cells
2021
Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox
2016 StandoutNobel
Myeloid-Derived Suppressor Cells
2017
Crystal Structures of Protein-Bound Cyclic Peptides
2019
Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations
2018
Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit
2019
KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy
2014
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
2021 Standout
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
2020 Standout
Structure of yeast Ape1 and its role in autophagic vesicle formation
2015
Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells
2016
Fluorescent chemosensors: the past, present and future
2017 Standout
Medulloblastoma genomics in the modern molecular era
2019
Precise and Ultrafast Molecular Sieving Through Graphene Oxide Membranes
2014 StandoutScienceNobel
Fast Rescoring Protocols to Improve the Performance of Structure-Based Virtual Screening Performed on Protein–Protein Interfaces
2020
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
2018
Redox regulation of tyrosine kinase signalling: more than meets the eye
2019
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease
2016
PubChem 2023 update
2022 Standout
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Arsenate Replacing Phosphate: Alternative Life Chemistries and Ion Promiscuity
2011
Metabolic reprogramming and cancer progression
2020 StandoutScience
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Multiple binding modes of a small molecule to human Keap1 revealed by X‐ray crystallography and molecular dynamics simulation
2015
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
2022
Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy
2019
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
2020
Targeting claudins in cancer: diagnosis, prognosis and therapy.
2021
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Specificity, versatility, and control of TGF-β family signaling
2019
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia
2021 StandoutNobel
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
PubChem in 2021: new data content and improved web interfaces
2020 Standout
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Chalcogen Bonding: An Overview
2018 Standout
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Protein Assembly by Design
2021
New Electrophiles and Strategies for Mechanism-Based and Targeted Covalent Inhibitor Design
2019
Comprehensive Review of Methodology to Detect Reactive Oxygen Species (ROS) in Mammalian Species and Establish Its Relationship with Antioxidants and Cancer
2021
Altered copper homeostasis underlies sensitivity of hepatocellular carcinoma to copper chelation
2020
Works of A. Chaikuad being referenced
The Cysteinome of Protein Kinases as a Target in Drug Development
2017
Halogen–Aromatic π Interactions Modulate Inhibitor Residence Times
2018
Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases
2013
Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases
2009
Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase
2011
The ins and outs of selective kinase inhibitor development
2015
A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics
2014
Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family
2012
Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1
2019
Modulation of the Chromatin Phosphoproteome by the Haspin Protein Kinase
2014
Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads
2016
Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva
2012
Radiolabeled cCPE Peptides for SPECT Imaging of Claudin-4 Overexpression in Pancreatic Cancer
2020
Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome
2019
Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket
2016
A New Class of Small Molecule Inhibitor of BMP Signaling
2013
Copper is required for oncogenic BRAF signalling and tumorigenesis
2014 Nature
Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
2018
Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B
2015
Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
2018
Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents
2015
Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease
2017
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)
2018
Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library
2016
A Specific and Covalent JNK‐1 Ligand Selected from an Encoded Self‐Assembling Chemical Library
2017
A core of kinase-regulated interactomes defines the neoplastic MDSC lineage
2015
A Consensus Compound/Bioactivity Dataset for Data-Driven Drug Design and Chemogenomics
2022